Efficiency of Multiple Extraction Solvents on Antioxidant, Cytotoxic, and Phytotoxic Potential of Taraxacum officinale (L.) Weber ex F.H. Wigg. from Poonch Valley, Azad Kashmir, Pakistan

Background. Different parts of Taraxacum officinale (L.) were used in traditional medicine in various parts of the world for the treatment of health problems, and they possess significant biological activities. The present study aimed to estimate phytochemical and biological activities of T. officin...

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Veröffentlicht in:Evidence-based complementary and alternative medicine 2022, Vol.2022, p.5118553-9
Hauptverfasser: Akhtar, Wasim, Ali, Ghazanfar, Ashraf, Nadia, Fatima, Iram, Kayani, Waqas Khan, Shaheen, Hamayun, Ghoneim, Mohammed M., Abdelgawad, Mohamed A., Khames, Ahmed
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container_start_page 5118553
container_title Evidence-based complementary and alternative medicine
container_volume 2022
creator Akhtar, Wasim
Ali, Ghazanfar
Ashraf, Nadia
Fatima, Iram
Kayani, Waqas Khan
Shaheen, Hamayun
Ghoneim, Mohammed M.
Abdelgawad, Mohamed A.
Khames, Ahmed
description Background. Different parts of Taraxacum officinale (L.) were used in traditional medicine in various parts of the world for the treatment of health problems, and they possess significant biological activities. The present study aimed to estimate phytochemical and biological activities of T. officinale using different extraction solvents. Methods. Methanolic, acetone, and n-hexane extracts of selected species were prepared, and ten secondary metabolites were examined using standard protocols. The antioxidant activity was performed using three in vitro methods, namely, DPPH assay, total reducing power (TRP) assay, and total antioxidant capacity (TAC). Toxicological analysis was done using the brine shrimp cytotoxic assay and radish seed phytotoxic assay. Results. The T. officinale methanolic extract showed the highest phenolic (178.27 ± 17.17 mg/GAE/g) and flavonoid (18.50 ± 1.64 mg QE/g) contents. Similarly, the methanolic extract also revealed the highest DPPH activity (32.80 ± 9.66 IC50), reducing potential (0.53 ± 0.02 mg/g), and TAC (19.42 ± 0.97 mg/g) as compared to the acetone and n-hexane extracts. The Pearson correlation analysis confirmed a strong positive correlation (r > 0.9) between total phenolic content (TPC), total flavonoid content (TFC), and all antioxidant assays. Furthermore, a heat map displayed the methanolic extract (red color) as a valuable source of phytochemicals and antioxidant agents. Moreover, the T. officinale methanolic extract also showed the highest (7.12 ppm) cytotoxic potential whereas both methanolic and acetone extracts were revealed as moderate phytotoxic agents when compared with the standard. Conclusion. The T. officinale methanolic extract exhibited comparatively notable phytochemicals that are actively involved in antioxidant activities and possess toxicological properties. This upholds the folkloric use of T. officinale as a possible source to develop natural plant-based drugs. Further investigations to isolate bioactive compounds and elements and on their safety need to be conducted.
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Weber ex F.H. Wigg. from Poonch Valley, Azad Kashmir, Pakistan</title><source>PubMed Central Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Wiley Online Library (Open Access Collection)</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Akhtar, Wasim ; Ali, Ghazanfar ; Ashraf, Nadia ; Fatima, Iram ; Kayani, Waqas Khan ; Shaheen, Hamayun ; Ghoneim, Mohammed M. ; Abdelgawad, Mohamed A. ; Khames, Ahmed</creator><contributor>Haq, Ihsan Ul ; Ihsan Ul Haq</contributor><creatorcontrib>Akhtar, Wasim ; Ali, Ghazanfar ; Ashraf, Nadia ; Fatima, Iram ; Kayani, Waqas Khan ; Shaheen, Hamayun ; Ghoneim, Mohammed M. ; Abdelgawad, Mohamed A. ; Khames, Ahmed ; Haq, Ihsan Ul ; Ihsan Ul Haq</creatorcontrib><description>Background. Different parts of Taraxacum officinale (L.) were used in traditional medicine in various parts of the world for the treatment of health problems, and they possess significant biological activities. The present study aimed to estimate phytochemical and biological activities of T. officinale using different extraction solvents. Methods. Methanolic, acetone, and n-hexane extracts of selected species were prepared, and ten secondary metabolites were examined using standard protocols. The antioxidant activity was performed using three in vitro methods, namely, DPPH assay, total reducing power (TRP) assay, and total antioxidant capacity (TAC). Toxicological analysis was done using the brine shrimp cytotoxic assay and radish seed phytotoxic assay. Results. The T. officinale methanolic extract showed the highest phenolic (178.27 ± 17.17 mg/GAE/g) and flavonoid (18.50 ± 1.64 mg QE/g) contents. Similarly, the methanolic extract also revealed the highest DPPH activity (32.80 ± 9.66 IC50), reducing potential (0.53 ± 0.02 mg/g), and TAC (19.42 ± 0.97 mg/g) as compared to the acetone and n-hexane extracts. The Pearson correlation analysis confirmed a strong positive correlation (r &gt; 0.9) between total phenolic content (TPC), total flavonoid content (TFC), and all antioxidant assays. Furthermore, a heat map displayed the methanolic extract (red color) as a valuable source of phytochemicals and antioxidant agents. Moreover, the T. officinale methanolic extract also showed the highest (7.12 ppm) cytotoxic potential whereas both methanolic and acetone extracts were revealed as moderate phytotoxic agents when compared with the standard. Conclusion. The T. officinale methanolic extract exhibited comparatively notable phytochemicals that are actively involved in antioxidant activities and possess toxicological properties. This upholds the folkloric use of T. officinale as a possible source to develop natural plant-based drugs. Further investigations to isolate bioactive compounds and elements and on their safety need to be conducted.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2022/5118553</identifier><identifier>PMID: 35698643</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Acetone ; Acids ; Antioxidants ; Bioactive compounds ; Chloride ; Correlation analysis ; Cytotoxicity ; Dietary minerals ; Flavonoids ; Herbal medicine ; Herbicides ; Medicine ; n-Hexane ; Phenolic compounds ; Phenols ; Phytochemicals ; Potassium ; Secondary metabolites ; Solvents ; Taraxacum officinale</subject><ispartof>Evidence-based complementary and alternative medicine, 2022, Vol.2022, p.5118553-9</ispartof><rights>Copyright © 2022 Wasim Akhtar et al.</rights><rights>Copyright © 2022 Wasim Akhtar et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 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The T. officinale methanolic extract showed the highest phenolic (178.27 ± 17.17 mg/GAE/g) and flavonoid (18.50 ± 1.64 mg QE/g) contents. Similarly, the methanolic extract also revealed the highest DPPH activity (32.80 ± 9.66 IC50), reducing potential (0.53 ± 0.02 mg/g), and TAC (19.42 ± 0.97 mg/g) as compared to the acetone and n-hexane extracts. The Pearson correlation analysis confirmed a strong positive correlation (r &gt; 0.9) between total phenolic content (TPC), total flavonoid content (TFC), and all antioxidant assays. Furthermore, a heat map displayed the methanolic extract (red color) as a valuable source of phytochemicals and antioxidant agents. Moreover, the T. officinale methanolic extract also showed the highest (7.12 ppm) cytotoxic potential whereas both methanolic and acetone extracts were revealed as moderate phytotoxic agents when compared with the standard. Conclusion. The T. officinale methanolic extract exhibited comparatively notable phytochemicals that are actively involved in antioxidant activities and possess toxicological properties. This upholds the folkloric use of T. officinale as a possible source to develop natural plant-based drugs. 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Weber ex F.H. Wigg. from Poonch Valley, Azad Kashmir, Pakistan</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2022</date><risdate>2022</risdate><volume>2022</volume><spage>5118553</spage><epage>9</epage><pages>5118553-9</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Background. Different parts of Taraxacum officinale (L.) were used in traditional medicine in various parts of the world for the treatment of health problems, and they possess significant biological activities. The present study aimed to estimate phytochemical and biological activities of T. officinale using different extraction solvents. Methods. Methanolic, acetone, and n-hexane extracts of selected species were prepared, and ten secondary metabolites were examined using standard protocols. The antioxidant activity was performed using three in vitro methods, namely, DPPH assay, total reducing power (TRP) assay, and total antioxidant capacity (TAC). Toxicological analysis was done using the brine shrimp cytotoxic assay and radish seed phytotoxic assay. Results. The T. officinale methanolic extract showed the highest phenolic (178.27 ± 17.17 mg/GAE/g) and flavonoid (18.50 ± 1.64 mg QE/g) contents. Similarly, the methanolic extract also revealed the highest DPPH activity (32.80 ± 9.66 IC50), reducing potential (0.53 ± 0.02 mg/g), and TAC (19.42 ± 0.97 mg/g) as compared to the acetone and n-hexane extracts. The Pearson correlation analysis confirmed a strong positive correlation (r &gt; 0.9) between total phenolic content (TPC), total flavonoid content (TFC), and all antioxidant assays. Furthermore, a heat map displayed the methanolic extract (red color) as a valuable source of phytochemicals and antioxidant agents. Moreover, the T. officinale methanolic extract also showed the highest (7.12 ppm) cytotoxic potential whereas both methanolic and acetone extracts were revealed as moderate phytotoxic agents when compared with the standard. Conclusion. The T. officinale methanolic extract exhibited comparatively notable phytochemicals that are actively involved in antioxidant activities and possess toxicological properties. This upholds the folkloric use of T. officinale as a possible source to develop natural plant-based drugs. Further investigations to isolate bioactive compounds and elements and on their safety need to be conducted.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>35698643</pmid><doi>10.1155/2022/5118553</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-1087-7327</orcidid><orcidid>https://orcid.org/0000-0002-8643-893X</orcidid><orcidid>https://orcid.org/0000-0001-5978-192X</orcidid><orcidid>https://orcid.org/0000-0002-6172-9503</orcidid><oa>free_for_read</oa></addata></record>
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subjects Acetone
Acids
Antioxidants
Bioactive compounds
Chloride
Correlation analysis
Cytotoxicity
Dietary minerals
Flavonoids
Herbal medicine
Herbicides
Medicine
n-Hexane
Phenolic compounds
Phenols
Phytochemicals
Potassium
Secondary metabolites
Solvents
Taraxacum officinale
title Efficiency of Multiple Extraction Solvents on Antioxidant, Cytotoxic, and Phytotoxic Potential of Taraxacum officinale (L.) Weber ex F.H. Wigg. from Poonch Valley, Azad Kashmir, Pakistan
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