Host hepatic metabolism is modulated by gut microbiota-derived sphingolipids

Microbially-derived gut metabolites are important contributors to host phenotypes, many of which may link microbiome composition to metabolic disease. However, relatively few metabolites with known bioactivity have been traced from specific microbes to host tissues. Here, we use a labeling strategy...

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Veröffentlicht in:	Cell host & microbe 2022-06, Vol.30 (6), p.798-808.e7
Hauptverfasser:	Le, Henry H., Lee, Min-Ting, Besler, Kevin R., Johnson, Elizabeth L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteroides thetaiotaomicron Bacteroides thetaiotaomicron - metabolism Gastrointestinal Microbiome gut microbiome hepatic steatosis Liver - metabolism metabolite tracing Mice Microbiota sphingolipids Sphingolipids - metabolism
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