Effectiveness of Proanthocyanidin plus Trimetazidine in the Treatment of Non-Small-Cell Lung Cancer with Radiation Heart Injury
This study was intended to explore the effect of proanthocyanidin (PC) combined with trimetazidine in non-small-cell lung cancer (NSCLC) with radiation-induced heart damage (RIHD). It was a prospective randomized controlled study that 86 NSCLC patients with radiation treatment in Cangzhou People’s H...
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| creator | Yin, Hang Zhao, Yue Sun, Yucui Liu, Jia Han, Yingjun Dai, Zhentao |
| description | This study was intended to explore the effect of proanthocyanidin (PC) combined with trimetazidine in non-small-cell lung cancer (NSCLC) with radiation-induced heart damage (RIHD). It was a prospective randomized controlled study that 86 NSCLC patients with radiation treatment in Cangzhou People’s Hospital from January 2019 and June 2021 were enrolled and randomized to either the control group or the study group via the random table method, 43 cases in each group. The control group received trimetazidine, and the study group additionally received PC. The incidence of RIHD-related clinical manifestation, RIHD-related ECG, and RIHD-related cardiac ultrasound change were all lower in the study group. After radiotherapy, the serum level of superoxide dismutase (SOD) was higher, and malondialdehyde (MDA) was lower in the study group when compared with the control group. After radiotherapy, the serum levels of brain natriuretic peptide (BNP), cardiac troponin (cTnT), creatine kinase (CK), and creatine kinase isoenzymes (CKMB) were all lower in the study group when compared with the control group. The efficacy of PC plus trimetazidine for NSCLC with RIHD is superior to trimetazidine alone, and it significantly mitigates radiation-induced inflammatory response and oxidative stress. |
| doi_str_mv | 10.1155/2022/2338622 |
| format | Article |
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It was a prospective randomized controlled study that 86 NSCLC patients with radiation treatment in Cangzhou People’s Hospital from January 2019 and June 2021 were enrolled and randomized to either the control group or the study group via the random table method, 43 cases in each group. The control group received trimetazidine, and the study group additionally received PC. The incidence of RIHD-related clinical manifestation, RIHD-related ECG, and RIHD-related cardiac ultrasound change were all lower in the study group. After radiotherapy, the serum level of superoxide dismutase (SOD) was higher, and malondialdehyde (MDA) was lower in the study group when compared with the control group. After radiotherapy, the serum levels of brain natriuretic peptide (BNP), cardiac troponin (cTnT), creatine kinase (CK), and creatine kinase isoenzymes (CKMB) were all lower in the study group when compared with the control group. The efficacy of PC plus trimetazidine for NSCLC with RIHD is superior to trimetazidine alone, and it significantly mitigates radiation-induced inflammatory response and oxidative stress.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2022/2338622</identifier><identifier>PMID: 35692580</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Angina pectoris ; Biological activity ; Brain natriuretic peptide ; Calcium-binding protein ; Cardiac arrhythmia ; Cardiovascular disease ; Chemotherapy ; Creatine ; Creatine kinase ; Diabetes ; Drug dosages ; EKG ; Electrocardiography ; Free radicals ; Heart ; Heart attacks ; Hypertension ; Inflammation ; Isoenzymes ; Lipids ; Lung cancer ; Metabolism ; Non-small cell lung carcinoma ; Oxidative stress ; Proanthocyanidins ; Radiation therapy ; Serum levels ; Small cell lung carcinoma ; Software ; Superoxide dismutase ; Trimetazidine ; Troponin ; Ultrasonic imaging</subject><ispartof>Evidence-based complementary and alternative medicine, 2022-06, Vol.2022, p.2338622-6</ispartof><rights>Copyright © 2022 Hang Yin et al.</rights><rights>Copyright © 2022 Hang Yin et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2022 Hang Yin et al. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-967805a614b5f5d92d4ddaa76179bf1e1f559912e86b8a6b42c11675d97506683</citedby><cites>FETCH-LOGICAL-c378t-967805a614b5f5d92d4ddaa76179bf1e1f559912e86b8a6b42c11675d97506683</cites><orcidid>0000-0002-1088-1775</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9187471/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9187471/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35692580$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Dong, Zhaoqi</contributor><contributor>Zhaoqi Dong</contributor><creatorcontrib>Yin, Hang</creatorcontrib><creatorcontrib>Zhao, Yue</creatorcontrib><creatorcontrib>Sun, Yucui</creatorcontrib><creatorcontrib>Liu, Jia</creatorcontrib><creatorcontrib>Han, Yingjun</creatorcontrib><creatorcontrib>Dai, Zhentao</creatorcontrib><title>Effectiveness of Proanthocyanidin plus Trimetazidine in the Treatment of Non-Small-Cell Lung Cancer with Radiation Heart Injury</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>This study was intended to explore the effect of proanthocyanidin (PC) combined with trimetazidine in non-small-cell lung cancer (NSCLC) with radiation-induced heart damage (RIHD). It was a prospective randomized controlled study that 86 NSCLC patients with radiation treatment in Cangzhou People’s Hospital from January 2019 and June 2021 were enrolled and randomized to either the control group or the study group via the random table method, 43 cases in each group. The control group received trimetazidine, and the study group additionally received PC. The incidence of RIHD-related clinical manifestation, RIHD-related ECG, and RIHD-related cardiac ultrasound change were all lower in the study group. After radiotherapy, the serum level of superoxide dismutase (SOD) was higher, and malondialdehyde (MDA) was lower in the study group when compared with the control group. After radiotherapy, the serum levels of brain natriuretic peptide (BNP), cardiac troponin (cTnT), creatine kinase (CK), and creatine kinase isoenzymes (CKMB) were all lower in the study group when compared with the control group. The efficacy of PC plus trimetazidine for NSCLC with RIHD is superior to trimetazidine alone, and it significantly mitigates radiation-induced inflammatory response and oxidative stress.</description><subject>Angina pectoris</subject><subject>Biological activity</subject><subject>Brain natriuretic peptide</subject><subject>Calcium-binding protein</subject><subject>Cardiac arrhythmia</subject><subject>Cardiovascular disease</subject><subject>Chemotherapy</subject><subject>Creatine</subject><subject>Creatine kinase</subject><subject>Diabetes</subject><subject>Drug dosages</subject><subject>EKG</subject><subject>Electrocardiography</subject><subject>Free radicals</subject><subject>Heart</subject><subject>Heart attacks</subject><subject>Hypertension</subject><subject>Inflammation</subject><subject>Isoenzymes</subject><subject>Lipids</subject><subject>Lung cancer</subject><subject>Metabolism</subject><subject>Non-small cell lung carcinoma</subject><subject>Oxidative 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It was a prospective randomized controlled study that 86 NSCLC patients with radiation treatment in Cangzhou People’s Hospital from January 2019 and June 2021 were enrolled and randomized to either the control group or the study group via the random table method, 43 cases in each group. The control group received trimetazidine, and the study group additionally received PC. The incidence of RIHD-related clinical manifestation, RIHD-related ECG, and RIHD-related cardiac ultrasound change were all lower in the study group. After radiotherapy, the serum level of superoxide dismutase (SOD) was higher, and malondialdehyde (MDA) was lower in the study group when compared with the control group. After radiotherapy, the serum levels of brain natriuretic peptide (BNP), cardiac troponin (cTnT), creatine kinase (CK), and creatine kinase isoenzymes (CKMB) were all lower in the study group when compared with the control group. The efficacy of PC plus trimetazidine for NSCLC with RIHD is superior to trimetazidine alone, and it significantly mitigates radiation-induced inflammatory response and oxidative stress.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>35692580</pmid><doi>10.1155/2022/2338622</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-1088-1775</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Angina pectoris Biological activity Brain natriuretic peptide Calcium-binding protein Cardiac arrhythmia Cardiovascular disease Chemotherapy Creatine Creatine kinase Diabetes Drug dosages EKG Electrocardiography Free radicals Heart Heart attacks Hypertension Inflammation Isoenzymes Lipids Lung cancer Metabolism Non-small cell lung carcinoma Oxidative stress Proanthocyanidins Radiation therapy Serum levels Small cell lung carcinoma Software Superoxide dismutase Trimetazidine Troponin Ultrasonic imaging |
| title | Effectiveness of Proanthocyanidin plus Trimetazidine in the Treatment of Non-Small-Cell Lung Cancer with Radiation Heart Injury |
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