Artificial Antigen Presenting Cells for Detection and Desensitization of Autoreactive T cells Associated with Type 1 Diabetes
Autoimmune diseases and in particular type 1 diabetes rely heavily on treatments that target the symptoms rather than prevent the underlying disease. One of the barriers to better therapeutic strategies is the inability to detect and efficiently target rare autoreactive T-cell populations that are m...
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| Veröffentlicht in: | Nano letters 2022-06, Vol.22 (11), p.4376-4382 |
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| container_issue | 11 |
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| container_title | Nano letters |
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| creator | Artzy-Schnirman, Arbel Abu-Shah, Enas Chandrawati, Rona Altman, Efrat Yusuf, Norkhairin Wang, Shih-Ting Ramos, Jose Hansel, Catherine S. Haus-Cohen, Maya Dahan, Rony Arif, Sefina Dustin, Michael L. Peakman, Mark Reiter, Yoram Stevens, Molly M. |
| description | Autoimmune diseases and in particular type 1 diabetes rely heavily on treatments that target the symptoms rather than prevent the underlying disease. One of the barriers to better therapeutic strategies is the inability to detect and efficiently target rare autoreactive T-cell populations that are major drivers of these conditions. Here, we develop a unique artificial antigen-presenting cell (aAPC) system from biocompatible polymer particles that allows specific encapsulation of bioactive ingredients. Using our aAPC, we demonstrate that we are able to detect rare autoreactive CD4 populations in human patients, and using mouse models, we demonstrate that our particles are able to induce desensitization in the autoreactive population. This system provides a promising tool that can be used in the prevention of autoimmunity before disease onset. |
| doi_str_mv | 10.1021/acs.nanolett.2c00819 |
| format | Article |
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One of the barriers to better therapeutic strategies is the inability to detect and efficiently target rare autoreactive T-cell populations that are major drivers of these conditions. Here, we develop a unique artificial antigen-presenting cell (aAPC) system from biocompatible polymer particles that allows specific encapsulation of bioactive ingredients. Using our aAPC, we demonstrate that we are able to detect rare autoreactive CD4 populations in human patients, and using mouse models, we demonstrate that our particles are able to induce desensitization in the autoreactive population. This system provides a promising tool that can be used in the prevention of autoimmunity before disease onset.</description><identifier>ISSN: 1530-6984</identifier><identifier>EISSN: 1530-6992</identifier><identifier>DOI: 10.1021/acs.nanolett.2c00819</identifier><identifier>PMID: 35616515</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Letter</subject><ispartof>Nano letters, 2022-06, Vol.22 (11), p.4376-4382</ispartof><rights>2022 The Authors. Published by American Chemical Society</rights><rights>2022 The Authors. 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One of the barriers to better therapeutic strategies is the inability to detect and efficiently target rare autoreactive T-cell populations that are major drivers of these conditions. Here, we develop a unique artificial antigen-presenting cell (aAPC) system from biocompatible polymer particles that allows specific encapsulation of bioactive ingredients. Using our aAPC, we demonstrate that we are able to detect rare autoreactive CD4 populations in human patients, and using mouse models, we demonstrate that our particles are able to induce desensitization in the autoreactive population. 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| ispartof | Nano letters, 2022-06, Vol.22 (11), p.4376-4382 |
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| language | eng |
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| source | American Chemical Society Journals |
| subjects | Letter |
| title | Artificial Antigen Presenting Cells for Detection and Desensitization of Autoreactive T cells Associated with Type 1 Diabetes |
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