Safety and Efficacy of a Large-Bore Biliary Metallic Stent for Malignant Biliary Obstruction
Self-expandable metallic stents (SEMSs) are typically inserted in patients with unresectable malignant biliary obstruction. However, SEMSs are susceptible to occlusion. To overcome this issue, we developed a large-bore, dumbbell-shaped, fully covered SEMS (FCSEMS-L) and compared its efficacy and saf...
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| Veröffentlicht in: | Journal of clinical medicine 2022-05, Vol.11 (11), p.3092 |
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| container_title | Journal of clinical medicine |
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| creator | Do, Min Young Jang, Sung Ill Cho, Jae Hee Kim, Yonsoo Kim, In-Jung Lee, Kwang-Hun Joo, Seung-Moon Lee, Dong Ki |
| description | Self-expandable metallic stents (SEMSs) are typically inserted in patients with unresectable malignant biliary obstruction. However, SEMSs are susceptible to occlusion. To overcome this issue, we developed a large-bore, dumbbell-shaped, fully covered SEMS (FCSEMS-L) and compared its efficacy and safety with those of a conventional FCSEMS (FCSEMS-C) in patients with malignant biliary obstruction.
Patients with unresectable distal malignant biliary obstruction were retrospectively enrolled between January 2011 and February 2021. All patients underwent endoscopic insertion of FCSEMSs. Recurrent biliary obstruction (RBO), patient survival time, complications, and prognosis were analyzed.
RBO occurred in 31 patients (35.6%) who received an FCSEMS-L, and in 34 (45.9%) who received an FCSEMS-C. Stent occlusion occurred in 19 patients (21.8%) who received an FCSEMS-L, and in 22 (29.7%) who received an FCSEMS-C. Stent migration occurred in 12 patients (13.8%) with an FCSEMS-L and 12 (16.2%) with an FCSEMS-C. The median time to RBO (TRBO) was 301 days with an FCSEMS-L and 203 days with an FCSEMS-C. The median survival time was 479 days with an FCSEMS-L and 523 days with an FCSEMS-C. The TRBO and patient survival time did not significantly differ between the two groups.
There were no significant differences in efficacy and complication rates between the fully covered large bore SEMSs and conventional fully covered SEMSs. |
| doi_str_mv | 10.3390/jcm11113092 |
| format | Article |
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Patients with unresectable distal malignant biliary obstruction were retrospectively enrolled between January 2011 and February 2021. All patients underwent endoscopic insertion of FCSEMSs. Recurrent biliary obstruction (RBO), patient survival time, complications, and prognosis were analyzed.
RBO occurred in 31 patients (35.6%) who received an FCSEMS-L, and in 34 (45.9%) who received an FCSEMS-C. Stent occlusion occurred in 19 patients (21.8%) who received an FCSEMS-L, and in 22 (29.7%) who received an FCSEMS-C. Stent migration occurred in 12 patients (13.8%) with an FCSEMS-L and 12 (16.2%) with an FCSEMS-C. The median time to RBO (TRBO) was 301 days with an FCSEMS-L and 203 days with an FCSEMS-C. The median survival time was 479 days with an FCSEMS-L and 523 days with an FCSEMS-C. The TRBO and patient survival time did not significantly differ between the two groups.
There were no significant differences in efficacy and complication rates between the fully covered large bore SEMSs and conventional fully covered SEMSs.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm11113092</identifier><identifier>PMID: 35683477</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Bile ducts ; Clinical medicine ; Clinical outcomes ; Endoscopy ; Medical prognosis ; Mortality ; Patients ; Statistical analysis ; Stents ; Success</subject><ispartof>Journal of clinical medicine, 2022-05, Vol.11 (11), p.3092</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c367t-51d91db9e88280a4e0a74a3f9b7d3a3597f859aa0c9cdf9a4bc019ce71b95f213</cites><orcidid>0000-0002-2351-2370 ; 0000-0003-4174-0091 ; 0000-0003-4937-6167</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181822/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181822/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35683477$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Do, Min Young</creatorcontrib><creatorcontrib>Jang, Sung Ill</creatorcontrib><creatorcontrib>Cho, Jae Hee</creatorcontrib><creatorcontrib>Kim, Yonsoo</creatorcontrib><creatorcontrib>Kim, In-Jung</creatorcontrib><creatorcontrib>Lee, Kwang-Hun</creatorcontrib><creatorcontrib>Joo, Seung-Moon</creatorcontrib><creatorcontrib>Lee, Dong Ki</creatorcontrib><title>Safety and Efficacy of a Large-Bore Biliary Metallic Stent for Malignant Biliary Obstruction</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>Self-expandable metallic stents (SEMSs) are typically inserted in patients with unresectable malignant biliary obstruction. However, SEMSs are susceptible to occlusion. To overcome this issue, we developed a large-bore, dumbbell-shaped, fully covered SEMS (FCSEMS-L) and compared its efficacy and safety with those of a conventional FCSEMS (FCSEMS-C) in patients with malignant biliary obstruction.
Patients with unresectable distal malignant biliary obstruction were retrospectively enrolled between January 2011 and February 2021. All patients underwent endoscopic insertion of FCSEMSs. Recurrent biliary obstruction (RBO), patient survival time, complications, and prognosis were analyzed.
RBO occurred in 31 patients (35.6%) who received an FCSEMS-L, and in 34 (45.9%) who received an FCSEMS-C. Stent occlusion occurred in 19 patients (21.8%) who received an FCSEMS-L, and in 22 (29.7%) who received an FCSEMS-C. Stent migration occurred in 12 patients (13.8%) with an FCSEMS-L and 12 (16.2%) with an FCSEMS-C. The median time to RBO (TRBO) was 301 days with an FCSEMS-L and 203 days with an FCSEMS-C. The median survival time was 479 days with an FCSEMS-L and 523 days with an FCSEMS-C. The TRBO and patient survival time did not significantly differ between the two groups.
There were no significant differences in efficacy and complication rates between the fully covered large bore SEMSs and conventional fully covered SEMSs.</description><subject>Bile ducts</subject><subject>Clinical medicine</subject><subject>Clinical outcomes</subject><subject>Endoscopy</subject><subject>Medical prognosis</subject><subject>Mortality</subject><subject>Patients</subject><subject>Statistical analysis</subject><subject>Stents</subject><subject>Success</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkc9LwzAYhoMoKnMn7xLwIkg1adomuQhu-AsmO0xvQviaJjOjazRphf33dupk-l2SkIc3T3gROqbkgjFJLhd6SfthRKY76DAlnCeECba7tT9AwxgXpB8hspTyfXTA8kKwjPND9DIDa9oVhqbCN9Y6DXqFvcWAJxDmJhn5YPDI1Q7CCj-aFuraaTxrTdNi6wN-hNrNG-hPG2haxjZ0unW-OUJ7Fupohj_rAD3f3jyN75PJ9O5hfD1JNCt4m-S0krQqpREiFQQyQ4BnwKwsecWA5ZJbkUsAoqWurISs1IRKbTgtZW5Tygbo6jv3rSuXptK9XIBavQW37I2UB6f-3jTuVc39h5JUUJGmfcDZT0Dw752JrVq6qE1dQ2N8F1Va8LygOSHrt07_oQvfhab_3prKWJHxL6Pzb0oHH2Mw9leGErUuTm0V19Mn2_6_7KYm9gnaa5OP</recordid><startdate>20220530</startdate><enddate>20220530</enddate><creator>Do, Min Young</creator><creator>Jang, Sung Ill</creator><creator>Cho, Jae Hee</creator><creator>Kim, Yonsoo</creator><creator>Kim, In-Jung</creator><creator>Lee, Kwang-Hun</creator><creator>Joo, Seung-Moon</creator><creator>Lee, Dong Ki</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2351-2370</orcidid><orcidid>https://orcid.org/0000-0003-4174-0091</orcidid><orcidid>https://orcid.org/0000-0003-4937-6167</orcidid></search><sort><creationdate>20220530</creationdate><title>Safety and Efficacy of a Large-Bore Biliary Metallic Stent for Malignant Biliary Obstruction</title><author>Do, Min Young ; Jang, Sung Ill ; Cho, Jae Hee ; Kim, Yonsoo ; Kim, In-Jung ; Lee, Kwang-Hun ; Joo, Seung-Moon ; Lee, Dong Ki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c367t-51d91db9e88280a4e0a74a3f9b7d3a3597f859aa0c9cdf9a4bc019ce71b95f213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Bile ducts</topic><topic>Clinical medicine</topic><topic>Clinical outcomes</topic><topic>Endoscopy</topic><topic>Medical prognosis</topic><topic>Mortality</topic><topic>Patients</topic><topic>Statistical analysis</topic><topic>Stents</topic><topic>Success</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Do, Min Young</creatorcontrib><creatorcontrib>Jang, Sung Ill</creatorcontrib><creatorcontrib>Cho, Jae Hee</creatorcontrib><creatorcontrib>Kim, Yonsoo</creatorcontrib><creatorcontrib>Kim, In-Jung</creatorcontrib><creatorcontrib>Lee, Kwang-Hun</creatorcontrib><creatorcontrib>Joo, Seung-Moon</creatorcontrib><creatorcontrib>Lee, Dong Ki</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Do, Min Young</au><au>Jang, Sung Ill</au><au>Cho, Jae Hee</au><au>Kim, Yonsoo</au><au>Kim, In-Jung</au><au>Lee, Kwang-Hun</au><au>Joo, Seung-Moon</au><au>Lee, Dong Ki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Safety and Efficacy of a Large-Bore Biliary Metallic Stent for Malignant Biliary Obstruction</atitle><jtitle>Journal of clinical medicine</jtitle><addtitle>J Clin Med</addtitle><date>2022-05-30</date><risdate>2022</risdate><volume>11</volume><issue>11</issue><spage>3092</spage><pages>3092-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>Self-expandable metallic stents (SEMSs) are typically inserted in patients with unresectable malignant biliary obstruction. However, SEMSs are susceptible to occlusion. To overcome this issue, we developed a large-bore, dumbbell-shaped, fully covered SEMS (FCSEMS-L) and compared its efficacy and safety with those of a conventional FCSEMS (FCSEMS-C) in patients with malignant biliary obstruction.
Patients with unresectable distal malignant biliary obstruction were retrospectively enrolled between January 2011 and February 2021. All patients underwent endoscopic insertion of FCSEMSs. Recurrent biliary obstruction (RBO), patient survival time, complications, and prognosis were analyzed.
RBO occurred in 31 patients (35.6%) who received an FCSEMS-L, and in 34 (45.9%) who received an FCSEMS-C. Stent occlusion occurred in 19 patients (21.8%) who received an FCSEMS-L, and in 22 (29.7%) who received an FCSEMS-C. Stent migration occurred in 12 patients (13.8%) with an FCSEMS-L and 12 (16.2%) with an FCSEMS-C. The median time to RBO (TRBO) was 301 days with an FCSEMS-L and 203 days with an FCSEMS-C. The median survival time was 479 days with an FCSEMS-L and 523 days with an FCSEMS-C. The TRBO and patient survival time did not significantly differ between the two groups.
There were no significant differences in efficacy and complication rates between the fully covered large bore SEMSs and conventional fully covered SEMSs.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>35683477</pmid><doi>10.3390/jcm11113092</doi><orcidid>https://orcid.org/0000-0002-2351-2370</orcidid><orcidid>https://orcid.org/0000-0003-4174-0091</orcidid><orcidid>https://orcid.org/0000-0003-4937-6167</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Bile ducts Clinical medicine Clinical outcomes Endoscopy Medical prognosis Mortality Patients Statistical analysis Stents Success |
| title | Safety and Efficacy of a Large-Bore Biliary Metallic Stent for Malignant Biliary Obstruction |
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