Inhibitors of Mitochondrial Human Carbonic Anhydrases VA and VB as a Therapeutic Strategy against Paclitaxel-Induced Neuropathic Pain in Mice

Neuropathy development is a major dose-limiting side effect of anticancer treatments that significantly reduces patient's quality of life. The inadequate pharmacological approaches for neuropathic pain management warrant the identification of novel therapeutic targets. Mitochondrial dysfunction...

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Veröffentlicht in:	International journal of molecular sciences 2022-06, Vol.23 (11), p.6229
Hauptverfasser:	Micheli, Laura, Testai, Lara, Angeli, Andrea, Carrino, Donatello, Pacini, Alessandra, Margiotta, Francesco, Flori, Lorenzo, Supuran, Claudiu T, Calderone, Vincenzo, Ghelardini, Carla, Di Cesare Mannelli, Lorenzo
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetazolamide Acidosis Animals Apoptosis Calcium ions Carbonic Anhydrase Inhibitors - pharmacology Carbonic Anhydrase Inhibitors - therapeutic use Carbonic Anhydrases - metabolism Cell activation Central nervous system Chemotherapy Citrate synthase Deregulation Drug development Drug dosages Enzymes Experiments Glial cells Homeostasis Humans Hyperalgesia Isoforms Lactic acid Membrane potential Mice Mitochondria Mitochondrial DNA Neuralgia - chemically induced Neuralgia - drug therapy Neuronal-glial interactions Neurotoxicity Oxidative stress Paclitaxel Paclitaxel - adverse effects Pain Pain management Pathology Phosphorylation Physiology Quality of Life Reactive oxygen species Rheumatoid arthritis Selenides Therapeutic targets
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