Formation of False Context Fear Memory Is Regulated by Hypothalamic Corticotropin-Releasing Factor in Mice

Traumatic events frequently produce false fear memories. We investigated the effect of hypothalamic corticotropin-releasing factor (CRF) knockdown (Hy- -KD) or overexpression (Hy-CRF-OE) on contextual fear memory, as fear stress-released CRF and hypothalamic-pituitary-adrenal axis activation affects...

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Veröffentlicht in:	International journal of molecular sciences 2022-06, Vol.23 (11), p.6286
Hauptverfasser:	Kasama, Emi, Moriya, Miho, Kamimura, Ryuma, Matsuki, Tohru, Seki, Kenjiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenocorticotropic Hormone - pharmacology Animals Chambers Conditioned stimulus Corticotropin-releasing hormone Corticotropin-Releasing Hormone - metabolism Fear Footshock Freezing Reaction, Cataleptic - physiology Hormones Hypothalamo-Hypophyseal System - metabolism Hypothalamus Locomotor activity Memory Mice Pituitary Pituitary Hormone-Releasing Hormones - pharmacology Pituitary-Adrenal System - metabolism Post traumatic stress disorder Tonic immobility Variance analysis
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