Venetoclax Induces Cardiotoxicity through Modulation of Oxidative-Stress-Mediated Cardiac Inflammation and Apoptosis via NF-κB and BCL-2 Pathway

Cardiovascular damage induced by anticancer therapy has become the main health problem after tumor elimination. Venetoclax (VTX) is a promising novel agent that has been proven to have a high efficacy in multiple hematological diseases, especially acute myeloid leukemia (AML) and chronic lymphocytic...

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Veröffentlicht in:	International journal of molecular sciences 2022-06, Vol.23 (11), p.6260
Hauptverfasser:	AlAsmari, Abdullah F, Alghamdi, Adel, Ali, Nemat, Almeaikl, Muath A, Hakami, Hassan M, Alyousef, Meshal K, AlSwayyed, Mohammed, Alharbi, Metab, Alqahtani, Faleh, Alasmari, Fawaz, Alsaleh, Nasser
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myeloid leukemia Animals Apoptosis Arrhythmias, Cardiac - complications Bcl-2 protein Bridged Bicyclo Compounds, Heterocyclic Cancer therapies Cardiotoxicity Cardiotoxicity - metabolism Chemotherapy Chronic lymphocytic leukemia Doxorubicin - pharmacology Drug dosages Drug withdrawal Enzymes Gene expression Heart Hematological diseases Inflammation Inflammation - metabolism Leukemia Lymphoma Male Markers Mortality NF-kappa B - metabolism NF-κB protein Oxidative Stress Proteins Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Rats Rats, Sprague-Dawley Sulfonamides Toxicity Tumors
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