Pitavastatin Is Anti-Leukemic in a Bone Marrow Microenvironment Model of B-Lineage Acute Lymphoblastic Leukemia

The lack of complete therapeutic success in the treatment of B-cell acute lymphoblastic leukemia (ALL) has been attributed, in part, to a subset of cells within the bone marrow microenvironment that are drug resistant. Recently, the cholesterol synthesis inhibitor, pitavastatin (PIT), was shown to b...

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Veröffentlicht in:	Cancers 2022-05, Vol.14 (11), p.2681
Hauptverfasser:	Piktel, Debbie, Nair, Rajesh R, Rellick, Stephanie L, Geldenhuys, Werner J, Martin, Karen H, Craig, Michael D, Gibson, Laura F
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphoblastic leukemia Acute lymphocytic leukemia Acute myeloid leukemia Antibiotics Bone marrow Cancer Care and treatment Cell culture Cell cycle Cell death Cell growth Chemoresistance Chemotherapy Cholesterol Clinical trials Cytarabine Diagnosis Drug resistance Gene expression Health aspects Kinases Leukemia Lipid metabolism Lipids Lymphocytes B Medical prognosis Metabolism Microenvironments Patient outcomes Patients Population Prevention Proteins Stromal cells
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