Immune-Desert Tumor Microenvironment in Thoracic SMARCA4-Deficient Undifferentiated Tumors with Limited Efficacy of Immune Checkpoint Inhibitors

Thoracic SMARCA4-deficient undifferentiated tumors (SMARCA4-UT) are aggressive neoplasms. Data linking BAF alterations with tumor microenvironment (TME) and efficacy of immune checkpoint inhibitors (ICI) are contradictory. The TME of SMARCA4-UT and their response to ICI are unknown. Patients diagnos...

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Veröffentlicht in:	The oncologist (Dayton, Ohio) Ohio), 2022-06, Vol.27 (6), p.501-511
Hauptverfasser:	Gantzer, Justine, Davidson, Guillaume, Vokshi, Bujamin, Weingertner, Noëlle, Bougoüin, Antoine, Moreira, Marco, Lindner, Véronique, Lacroix, Guillaume, Mascaux, Céline, Chenard, Marie-Pierre, Bertucci, François, Davidson, Irwin, Kurtz, Jean-Emmanuel, Sautès-Fridman, Catherine, Fridman, Wolf H, Malouf, Gabriel G
Format:	Artikel
Sprache:	eng
Schlagworte:	B cells Biological response modifiers Cancer Development and progression Drug therapy Enzyme inhibitors Gene mutations Genetic aspects Genetic regulation Health aspects Immunotherapy Interferon Ipilimumab Life Sciences Lung cancer, Non-small cell Patient outcomes Sarcoma Sarcomas Thoracic tumors
Online-Zugang:	Volltext
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