JAK inhibition in early-onset somatic, nonclonal STAT5B gain-of-function disease

Early-onset somatic signal transducer and activator of transcription 5B(STAT5B) gain-of-function is a newly recognized monogenic atopic disorder, now with demonstrable sustained response to targeted therapy. Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathways medi...

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Veröffentlicht in:	The journal of allergy and clinical immunology in practice (Cambridge, MA) MA), 2021-02, Vol.9 (2), p.1008-1010.e2
Hauptverfasser:	Eisenberg, Rachel, Gans, Melissa D., Leahy, Timothy Ronan, Gothe, Florian, Perry, Candice, Raffeld, Mark, Xi, Liqiang, Blackstone, Sarah, Ma, Chi, Hambleton, Sophie, Milner, Joshua D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Anemia Antigens Atopy Bone marrow Child, Preschool Cytokines Dermatitis Diarrhea Enzymes Eosinophilia Failure to thrive Food allergies Gain of Function Mutation Gene expression Humans Illnesses Janus kinase Janus Kinases - antagonists & inhibitors Kinases Laboratories Lymphocytes Lymphoma Male Mutation Phenotypes Phosphorylation Staphylococcus infections STAT5 Transcription Factor - genetics STAT5 Transcription Factor - metabolism Transcription Tumors Urticaria
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