Gene discovery and virus-induced gene silencing reveal branched pathways to major classes of bioactive diterpenoids in Euphorbia peplus

Significance , a member of the genus, is rich in jatrophane and ingenane diterpenoids. Using a metabolomics-guided transcriptomic approach to gene candidate identification, we have discovered a short-chain dehydrogenase gene involved in the production of the lathyrane jolkinol E. We have developed a...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2022-05, Vol.119 (21), p.e2203890119-e2203890119
Hauptverfasser:	Czechowski, Tomasz, Forestier, Edith, Swamidatta, Sandesh H, Gilday, Alison D, Cording, Amy, Larson, Tony R, Harvey, David, Li, Yi, He, Zhesi, King, Andrew J, Brown, Geoffrey D, Graham, Ian A
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological activity Biological Sciences Casbene synthase Diterpenes Euphorbia peplus Gene clusters Gene sequencing Gene silencing In vivo methods and tests Latex Metabolomics Reductases Reduction Transcriptomics Viruses
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