Phosphaturic Mesenchymal Tumor
Phosphaturic mesenchymal tumors (PMTs) are neoplasms associated with tumor-induced osteomalacia. Patients typically present with pathologic fractures in the setting of chronic hypophosphatemic hyperphosphaturic osteomalacia, as well as gradual muscle weakness, bone pain, and difficulty walking. Beca...
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Veröffentlicht in: | American journal of neuroradiology : AJNR 2022-06, Vol.43 (6), p.817-822 |
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creator | Benson, J C Trejo-Lopez, J A Nassiri, A M Eschbacher, K Link, M J Driscoll, C L Tiegs, R D Sfeir, J DeLone, D R |
description | Phosphaturic mesenchymal tumors (PMTs) are neoplasms associated with tumor-induced osteomalacia. Patients typically present with pathologic fractures in the setting of chronic hypophosphatemic hyperphosphaturic osteomalacia, as well as gradual muscle weakness, bone pain, and difficulty walking. Because of their rarity and nonspecific symptomatology, phosphaturic mesenchymal tumors often go undiagnosed for years. Even when discovered on imaging, the tumors can be diagnostically challenging for radiologists. Phosphaturic mesenchymal tumors often tend to be small and can be located nearly anywhere in the body, and, therefore, can mimic many other tumors. This case highlights the imaging and pathologic markers of a phosphaturic mesenchymal tumor, often found in a patient with tumor-induced osteomalacia. |
doi_str_mv | 10.3174/ajnr.A7513 |
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Patients typically present with pathologic fractures in the setting of chronic hypophosphatemic hyperphosphaturic osteomalacia, as well as gradual muscle weakness, bone pain, and difficulty walking. Because of their rarity and nonspecific symptomatology, phosphaturic mesenchymal tumors often go undiagnosed for years. Even when discovered on imaging, the tumors can be diagnostically challenging for radiologists. Phosphaturic mesenchymal tumors often tend to be small and can be located nearly anywhere in the body, and, therefore, can mimic many other tumors. This case highlights the imaging and pathologic markers of a phosphaturic mesenchymal tumor, often found in a patient with tumor-induced osteomalacia.</description><identifier>ISSN: 0195-6108</identifier><identifier>EISSN: 1936-959X</identifier><identifier>DOI: 10.3174/ajnr.A7513</identifier><identifier>PMID: 35589138</identifier><language>eng</language><publisher>United States: American Society of Neuroradiology</publisher><subject>Head & Neck ; Humans ; Mesenchymoma - diagnosis ; Mesenchymoma - diagnostic imaging ; Neoplasms, Connective Tissue - diagnosis ; Neoplasms, Connective Tissue - diagnostic imaging ; Osteomalacia - diagnostic imaging ; Osteomalacia - etiology ; Paraneoplastic Syndromes - complications ; Paraneoplastic Syndromes - diagnostic imaging</subject><ispartof>American journal of neuroradiology : AJNR, 2022-06, Vol.43 (6), p.817-822</ispartof><rights>2022 by American Journal of Neuroradiology.</rights><rights>2022 by American Journal of Neuroradiology 2022 American Journal of Neuroradiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-7158811bf9e1e2331b4195b986b00f198b0a6d07eda6d74d1867e5950b7f47d53</citedby><cites>FETCH-LOGICAL-c378t-7158811bf9e1e2331b4195b986b00f198b0a6d07eda6d74d1867e5950b7f47d53</cites><orcidid>0000-0002-2102-6897 ; 0000-0002-8289-3222 ; 0000-0002-4038-5422 ; 0000-0001-5346-7753 ; 0000-0001-9665-1868 ; 0000-0001-8482-3968 ; 0000-0003-1576-1534 ; 0000-0002-8522-2723 ; 0000-0002-4211-8790</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9172954/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9172954/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35589138$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Benson, J C</creatorcontrib><creatorcontrib>Trejo-Lopez, J A</creatorcontrib><creatorcontrib>Nassiri, A M</creatorcontrib><creatorcontrib>Eschbacher, K</creatorcontrib><creatorcontrib>Link, M J</creatorcontrib><creatorcontrib>Driscoll, C L</creatorcontrib><creatorcontrib>Tiegs, R D</creatorcontrib><creatorcontrib>Sfeir, J</creatorcontrib><creatorcontrib>DeLone, D R</creatorcontrib><title>Phosphaturic Mesenchymal Tumor</title><title>American journal of neuroradiology : AJNR</title><addtitle>AJNR Am J Neuroradiol</addtitle><description>Phosphaturic mesenchymal tumors (PMTs) are neoplasms associated with tumor-induced osteomalacia. Patients typically present with pathologic fractures in the setting of chronic hypophosphatemic hyperphosphaturic osteomalacia, as well as gradual muscle weakness, bone pain, and difficulty walking. Because of their rarity and nonspecific symptomatology, phosphaturic mesenchymal tumors often go undiagnosed for years. Even when discovered on imaging, the tumors can be diagnostically challenging for radiologists. Phosphaturic mesenchymal tumors often tend to be small and can be located nearly anywhere in the body, and, therefore, can mimic many other tumors. This case highlights the imaging and pathologic markers of a phosphaturic mesenchymal tumor, often found in a patient with tumor-induced osteomalacia.</description><subject>Head & Neck</subject><subject>Humans</subject><subject>Mesenchymoma - diagnosis</subject><subject>Mesenchymoma - diagnostic imaging</subject><subject>Neoplasms, Connective Tissue - diagnosis</subject><subject>Neoplasms, Connective Tissue - diagnostic imaging</subject><subject>Osteomalacia - diagnostic imaging</subject><subject>Osteomalacia - etiology</subject><subject>Paraneoplastic Syndromes - complications</subject><subject>Paraneoplastic Syndromes - diagnostic imaging</subject><issn>0195-6108</issn><issn>1936-959X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkEtLw0AUhQdRbK1u_AGlSxFS52Yyr41Qii-o6KKCu2EmmZiUJFNnEqH_3tTWoquzuB_nXD6ELgFPCfDkRq8aP51xCuQIDUESFkkq34_REIOkEQMsBugshBXGmEoen6IBoVRIIGKIxq-FC-tCt50v08mzDbZJi02tq8myq50_Rye5roK92OcIvd3fLeeP0eLl4Wk-W0Qp4aKNOFAhAEwuLdiYEDBJP22kYAbjHKQwWLMMc5v1wZMMBOOWSooNzxOeUTJCt7vedWdqm6W2ab2u1NqXtfYb5XSp_l-aslAf7ktJ4LGkSV9wtS_w7rOzoVV1GVJbVbqxrgsqZoxzGQtBevR6h6beheBtfpgBrLZC1Vao-hHaw-O_jx3QX4PkG5mIcRA</recordid><startdate>202206</startdate><enddate>202206</enddate><creator>Benson, J C</creator><creator>Trejo-Lopez, J A</creator><creator>Nassiri, A M</creator><creator>Eschbacher, K</creator><creator>Link, M J</creator><creator>Driscoll, C L</creator><creator>Tiegs, R D</creator><creator>Sfeir, J</creator><creator>DeLone, D R</creator><general>American Society of Neuroradiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2102-6897</orcidid><orcidid>https://orcid.org/0000-0002-8289-3222</orcidid><orcidid>https://orcid.org/0000-0002-4038-5422</orcidid><orcidid>https://orcid.org/0000-0001-5346-7753</orcidid><orcidid>https://orcid.org/0000-0001-9665-1868</orcidid><orcidid>https://orcid.org/0000-0001-8482-3968</orcidid><orcidid>https://orcid.org/0000-0003-1576-1534</orcidid><orcidid>https://orcid.org/0000-0002-8522-2723</orcidid><orcidid>https://orcid.org/0000-0002-4211-8790</orcidid></search><sort><creationdate>202206</creationdate><title>Phosphaturic Mesenchymal Tumor</title><author>Benson, J C ; Trejo-Lopez, J A ; Nassiri, A M ; Eschbacher, K ; Link, M J ; Driscoll, C L ; Tiegs, R D ; Sfeir, J ; DeLone, D R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-7158811bf9e1e2331b4195b986b00f198b0a6d07eda6d74d1867e5950b7f47d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Head & Neck</topic><topic>Humans</topic><topic>Mesenchymoma - diagnosis</topic><topic>Mesenchymoma - diagnostic imaging</topic><topic>Neoplasms, Connective Tissue - diagnosis</topic><topic>Neoplasms, Connective Tissue - diagnostic imaging</topic><topic>Osteomalacia - diagnostic imaging</topic><topic>Osteomalacia - etiology</topic><topic>Paraneoplastic Syndromes - complications</topic><topic>Paraneoplastic Syndromes - diagnostic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Benson, J C</creatorcontrib><creatorcontrib>Trejo-Lopez, J A</creatorcontrib><creatorcontrib>Nassiri, A M</creatorcontrib><creatorcontrib>Eschbacher, K</creatorcontrib><creatorcontrib>Link, M J</creatorcontrib><creatorcontrib>Driscoll, C L</creatorcontrib><creatorcontrib>Tiegs, R D</creatorcontrib><creatorcontrib>Sfeir, J</creatorcontrib><creatorcontrib>DeLone, D R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of neuroradiology : AJNR</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Benson, J C</au><au>Trejo-Lopez, J A</au><au>Nassiri, A M</au><au>Eschbacher, K</au><au>Link, M J</au><au>Driscoll, C L</au><au>Tiegs, R D</au><au>Sfeir, J</au><au>DeLone, D R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phosphaturic Mesenchymal Tumor</atitle><jtitle>American journal of neuroradiology : AJNR</jtitle><addtitle>AJNR Am J Neuroradiol</addtitle><date>2022-06</date><risdate>2022</risdate><volume>43</volume><issue>6</issue><spage>817</spage><epage>822</epage><pages>817-822</pages><issn>0195-6108</issn><eissn>1936-959X</eissn><abstract>Phosphaturic mesenchymal tumors (PMTs) are neoplasms associated with tumor-induced osteomalacia. Patients typically present with pathologic fractures in the setting of chronic hypophosphatemic hyperphosphaturic osteomalacia, as well as gradual muscle weakness, bone pain, and difficulty walking. Because of their rarity and nonspecific symptomatology, phosphaturic mesenchymal tumors often go undiagnosed for years. Even when discovered on imaging, the tumors can be diagnostically challenging for radiologists. Phosphaturic mesenchymal tumors often tend to be small and can be located nearly anywhere in the body, and, therefore, can mimic many other tumors. 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subjects | Head & Neck Humans Mesenchymoma - diagnosis Mesenchymoma - diagnostic imaging Neoplasms, Connective Tissue - diagnosis Neoplasms, Connective Tissue - diagnostic imaging Osteomalacia - diagnostic imaging Osteomalacia - etiology Paraneoplastic Syndromes - complications Paraneoplastic Syndromes - diagnostic imaging |
title | Phosphaturic Mesenchymal Tumor |
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