Maladaptation after a virus host switch leads to increased activation of the pro-inflammatory NF-κB pathway

SignificanceMyxoma virus (MYXV) is benign in the natural brush rabbit host but causes a fatal disease in European rabbits. Here, we demonstrate that MYXV M156 inhibited brush rabbit protein kinase R (bPKR) more efficiently than European rabbit PKR (ePKR). Because ePKR was not completely inhibited by...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2022-05, Vol.119 (20), p.e2115354119-e2115354119
Hauptverfasser:	Yu, Huibin, Peng, Chen, Zhang, Chi, Stoian, Ana M M, Tazi, Loubna, Brennan, Greg, Rothenburg, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Crosstalk Depletion eIF-2 kinase eIF-2 Kinase - metabolism Host-Pathogen Interactions Inflammation Inhibition Interleukin 6 Kinases Metabolic Networks and Pathways Molecular modelling Mutants Myxoma Myxoma virus - genetics Myxoma virus - pathogenicity Myxomatosis Myxomatosis, Infectious - metabolism Myxomatosis, Infectious - virology NF-kappa B - metabolism NF-KappaB Inhibitor alpha - metabolism NF-κB protein Protein kinase R Proteins Rabbits Rabbits - virology Signal transduction Transfection Tumor necrosis factor-α Virulence Viruses
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