Developmental arsenic exposure impairs cognition, directly targets DNMT3A, and reduces DNA methylation

Developmental arsenic exposure has been associated with cognitive deficits in epidemiological studies, but the underlying mechanisms remain poorly understood. Here, we establish a mouse model of developmental arsenic exposure exhibiting deficits of recognition and spatial memory in the offspring. Th...

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Veröffentlicht in:	EMBO reports 2022-06, Vol.23 (6), p.e54147-n/a
Hauptverfasser:	Yan, Ni, Li, Yuntong, Xing, Yangfei, Wu, Jiale, Li, Jiabing, Liang, Ying, Tang, Yigang, Wang, Zhengyuan, Song, Huaxin, Wang, Haoyu, Xiao, Shujun, Lu, Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidiabetics Arsenic Arsenic - toxicity Cell lines Cognition Cognition & reasoning Cognitive ability Degradation Deoxyribonucleic acid Diabetes mellitus DNA DNA Methylation DNA methyltransferase DNA Methyltransferase 3A DNMT3A EMBO09 EMBO27 Embryo fibroblasts Epidemiology Exposure Female Fibroblasts Fibroblasts - metabolism Gene expression Genes Genomes Hippocampus Humans Memory tasks Metformin Mice Offspring Pregnancy Proteasomes Spatial analysis Spatial memory Ubiquitin
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