Transforming primary human hepatocytes into hepatocellular carcinoma with genetically defined factors

Our understanding of human hepatocellular carcinoma (HCC) development and progression has been hampered by the lack of in vivo models. We performed a genetic screen of 10 oncogenes and genetic mutations in Fah ‐ablated immunodeficient mice in which primary human hepatocytes (PHHs) are used to recons...

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Veröffentlicht in:	EMBO reports 2022-06, Vol.23 (6), p.e54275-n/a
Hauptverfasser:	Jiang, Zhiwu, Cheng, Lin, Wu, Zhiping, Zhou, Linfu, Wang, Haitao, Hong, Qilan, Wu, Qiting, Long, Youguo, Huang, Yunlin, Xu, Gaoqi, Yao, Yao, Tang, Zhaoyang, Zhang, Zhenfeng, Yang, Lili, Luo, Wei, Yang, Jie, Gong, Likun, Liu, Pentao, Chen, Xinwen, Cui, Shuzhong, Zhang, Qi, Li, Yinxiong, Li, Peng
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Animal models Animals Antigens Biomarkers Carcinoma, Hepatocellular - genetics Chimeric antigen receptors Diagnostic systems EMBO03 EMBO22 EMBO37 Gene expression Genetic screening Hepatocellular carcinoma Hepatocytes humanized mouse models Humans Immunodeficiency Immunotherapy In vivo methods and tests Liver cancer Liver Neoplasms - genetics Liver Neoplasms - pathology Lymphocytes Lymphocytes T Mice Mutation Myc protein oncogenes Proto-Oncogene Proteins p21(ras) Surface markers Therapeutic targets Transcriptomics
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