Adoptive transfer of ex vivo expanded regulatory T cells improves immune cell engraftment and therapy-refractory chronic GvHD

Graft-versus-host disease (GvHD) is still the major non-relapse, life-limiting complication after hematopoietic stem cell transplantation. Modern pharmacologic immunosuppression is often insufficient and associated with significant side effects. Novel treatment strategies now include adoptive transf...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Molecular therapy 2022-06, Vol.30 (6), p.2298-2314
Hauptverfasser:	Landwehr-Kenzel, Sybille, Müller-Jensen, Leonie, Kuehl, Joern-Sven, Abou-el-Enein, Mohamed, Hoffmann, Henrike, Muench, Sandra, Kaiser, Daniel, Roemhild, Andy, von Bernuth, Horst, Voeller, Mirjam, Schmueck-Henneresse, Michael, Gruhn, Bernd, Stervbo, Ulrik, Babel, Nina, Volk, Hans-Dieter, Reinke, Petra
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer adoptive T cell therapy Child chronic graft-versus-host disease clinical immunology Graft vs Host Disease - etiology Graft vs Host Disease - therapy hematopoietic stem cell transplantation Hematopoietic Stem Cell Transplantation - adverse effects Humans Immunosuppression Therapy Original regulatory T cells T-Lymphocytes, Regulatory
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!