Antibody-mediated blockade of the IL23 receptor destabilizes intratumoral regulatory T cells and enhances immunotherapy

Regulatory T cells (Treg) can impede antitumor immunity and currently represent a major obstacle to effective cancer immunotherapy. Targeting tumor-infiltrating regulatory Treg while sparing systemic Treg represents an optimal approach to this problem. Here, we provide evidence that the interleukin...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2022-05, Vol.119 (18), p.1-8
Hauptverfasser:	Wight, Andrew E., Sido, Jessica M., Degryse, Sandrine, Ao, Lin, Nakagawa, Hidetoshi, Qiu(Vivian), Yiguo, Shen, Xianli, Oseghali, Oba, Kim, Hye-Jung, Cantor, Harvey
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antibodies, Blocking Antitumor activity Biological Sciences Cancer Cancer immunotherapy CD8 antigen Cytokines Destabilization Glucocorticoids Humans Immunologic Factors - metabolism Immunoregulation Immunotherapy Interferon Interleukin 1 Interleukin 12 Interleukin 23 Interleukin-23 - metabolism Lymphocytes Lymphocytes T Neoplasms - metabolism Receptors T-Lymphocytes, Regulatory Tumor necrosis factor receptors Tumor-infiltrating lymphocytes Tumors γ-Interferon
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