Lysosomes are required for early dorsal signaling in the Xenopus embryo

Lysosomes are the digestive center of the cell and play important roles in human diseases, including cancer. Previous work has suggested that late endosomes, also known as multivesicular bodies (MVBs), and lysosomes are essential for canonical Wnt pathway signaling. Sequestration of Glycogen Synthas...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2022-04, Vol.119 (17), p.e2201008119-e2201008119
Hauptverfasser:	Tejeda-Muñoz, Nydia, De Robertis, Edward M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidification Adenosine triphosphatase Animals Biological Sciences Body Patterning Cathepsin D Concanamycin A Embryo, Mammalian Embryo, Nonmammalian Embryos Endosomes Glycogen Glycogen synthase Glycogens H+-transporting ATPase Hydroxychloroquine Lithium Lithium chloride Lysosomes Membrane trafficking mRNA Mutation Point mutation Protein transport Signal Transduction Signaling Transcription Vertebrates Wnt protein Xenopus Xenopus laevis Xenopus Proteins
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