A virtual host model of Mycobacterium tuberculosis infection identifies early immune events as predictive of infection outcomes

•We present HostSim, a multiscale virtual host model of Mtb infection.•We create a virtual human population that exhibits a spectrum of clinical outcomes.•Early events may be predictive of clinical outcomes hundreds of days later.•Simulations suggest that biomarkers of TB progression may be transien...

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Veröffentlicht in:	Journal of theoretical biology 2022-04, Vol.539 (C), p.111042-111042, Article 111042
Hauptverfasser:	Joslyn, Louis R., Linderman, Jennifer J., Kirschner, Denise E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Digital twins Granuloma - pathology Lung - microbiology Mechanistic modeling Multi-scale modeling Mycobacterium tuberculosis Primates Systems biology T cells Tuberculosis
Online-Zugang:	Volltext
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