Pyroptosis in inflammatory diseases and cancer
Pyroptosis is a lytic and inflammatory type of programmed cell death that is usually triggered by inflammasomes and executed by gasdermin proteins. The main characteristics of pyroptosis are cell swelling, membrane perforation, and the release of cell contents. In normal physiology, pyroptosis plays...
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| Veröffentlicht in: | Theranostics 2022-01, Vol.12 (9), p.4310-4329 |
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| creator | Rao, Zhiping Zhu, Yutong Yang, Peng Chen, Zhuang Xia, Yuqiong Qiao, Chaoqiang Liu, Weijing Deng, Hongzhang Li, Jianxiong Ning, Pengbo Wang, Zhongliang |
| description | Pyroptosis is a lytic and inflammatory type of programmed cell death that is usually triggered by inflammasomes and executed by gasdermin proteins. The main characteristics of pyroptosis are cell swelling, membrane perforation, and the release of cell contents. In normal physiology, pyroptosis plays a critical role in host defense against pathogen infection. However, excessive pyroptosis may cause immoderate and continuous inflammatory responses that involves in the occurrence of inflammatory diseases. Attractively, as immunogenic cell death, pyroptosis can serve as a new strategy for cancer elimination by inducing pyroptotic cell death and activating intensely antitumor immunity. To make good use of this double-edged sword, the molecular mechanisms, and therapeutic implications of pyroptosis in related diseases need to be fully elucidated. In this review, we first systematically summarize the signaling pathways of pyroptosis and then present the available evidences indicating the role of pyroptosis in inflammatory diseases and cancer. Based on this, we focus on the recent progress in strategies that inhibit pyroptosis for treatment of inflammatory diseases, and those that induce pyroptosis for cancer therapy. Overall, this should shed light on future directions and provide novel ideas for using pyroptosis as a powerful tool to fight inflammatory diseases and cancer. |
| doi_str_mv | 10.7150/thno.71086 |
| format | Article |
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The main characteristics of pyroptosis are cell swelling, membrane perforation, and the release of cell contents. In normal physiology, pyroptosis plays a critical role in host defense against pathogen infection. However, excessive pyroptosis may cause immoderate and continuous inflammatory responses that involves in the occurrence of inflammatory diseases. Attractively, as immunogenic cell death, pyroptosis can serve as a new strategy for cancer elimination by inducing pyroptotic cell death and activating intensely antitumor immunity. To make good use of this double-edged sword, the molecular mechanisms, and therapeutic implications of pyroptosis in related diseases need to be fully elucidated. In this review, we first systematically summarize the signaling pathways of pyroptosis and then present the available evidences indicating the role of pyroptosis in inflammatory diseases and cancer. Based on this, we focus on the recent progress in strategies that inhibit pyroptosis for treatment of inflammatory diseases, and those that induce pyroptosis for cancer therapy. Overall, this should shed light on future directions and provide novel ideas for using pyroptosis as a powerful tool to fight inflammatory diseases and cancer.</description><identifier>ISSN: 1838-7640</identifier><identifier>EISSN: 1838-7640</identifier><identifier>DOI: 10.7150/thno.71086</identifier><identifier>PMID: 35673561</identifier><language>eng</language><publisher>Australia: Ivyspring International Publisher Pty Ltd</publisher><subject>Adenosine triphosphate ; Apoptosis ; Bacteria ; Cancer ; Cytokines ; Gram-negative bacteria ; Humans ; Inflammasomes - metabolism ; Inflammatory diseases ; Kinases ; Neoplasms ; Pathogens ; Proteins ; Pyroptosis - physiology ; Review ; Salmonella ; Signal Transduction</subject><ispartof>Theranostics, 2022-01, Vol.12 (9), p.4310-4329</ispartof><rights>The author(s).</rights><rights>2022. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The author(s) 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-407808fc3d93a5ad8f65aa544aca189ef3edd1182caf9e900483c880674d7cdf3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169370/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9169370/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35673561$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rao, Zhiping</creatorcontrib><creatorcontrib>Zhu, Yutong</creatorcontrib><creatorcontrib>Yang, Peng</creatorcontrib><creatorcontrib>Chen, Zhuang</creatorcontrib><creatorcontrib>Xia, Yuqiong</creatorcontrib><creatorcontrib>Qiao, Chaoqiang</creatorcontrib><creatorcontrib>Liu, Weijing</creatorcontrib><creatorcontrib>Deng, Hongzhang</creatorcontrib><creatorcontrib>Li, Jianxiong</creatorcontrib><creatorcontrib>Ning, Pengbo</creatorcontrib><creatorcontrib>Wang, Zhongliang</creatorcontrib><title>Pyroptosis in inflammatory diseases and cancer</title><title>Theranostics</title><addtitle>Theranostics</addtitle><description>Pyroptosis is a lytic and inflammatory type of programmed cell death that is usually triggered by inflammasomes and executed by gasdermin proteins. The main characteristics of pyroptosis are cell swelling, membrane perforation, and the release of cell contents. In normal physiology, pyroptosis plays a critical role in host defense against pathogen infection. However, excessive pyroptosis may cause immoderate and continuous inflammatory responses that involves in the occurrence of inflammatory diseases. Attractively, as immunogenic cell death, pyroptosis can serve as a new strategy for cancer elimination by inducing pyroptotic cell death and activating intensely antitumor immunity. To make good use of this double-edged sword, the molecular mechanisms, and therapeutic implications of pyroptosis in related diseases need to be fully elucidated. In this review, we first systematically summarize the signaling pathways of pyroptosis and then present the available evidences indicating the role of pyroptosis in inflammatory diseases and cancer. Based on this, we focus on the recent progress in strategies that inhibit pyroptosis for treatment of inflammatory diseases, and those that induce pyroptosis for cancer therapy. Overall, this should shed light on future directions and provide novel ideas for using pyroptosis as a powerful tool to fight inflammatory diseases and cancer.</description><subject>Adenosine triphosphate</subject><subject>Apoptosis</subject><subject>Bacteria</subject><subject>Cancer</subject><subject>Cytokines</subject><subject>Gram-negative bacteria</subject><subject>Humans</subject><subject>Inflammasomes - metabolism</subject><subject>Inflammatory diseases</subject><subject>Kinases</subject><subject>Neoplasms</subject><subject>Pathogens</subject><subject>Proteins</subject><subject>Pyroptosis - physiology</subject><subject>Review</subject><subject>Salmonella</subject><subject>Signal Transduction</subject><issn>1838-7640</issn><issn>1838-7640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkUtLAzEUhYMottRu_AFScCPC1GSSyWMjSPEFBV3oOlyTjJ0yM6nJjNB_b2qrVMMNuZCPk3NzEDoleCpIga-6RetThyU_QEMiqcwEZ_hwrx-gcYxLnBbDuSLqGA1owUXaZIimz-vgV52PVZxUbaqyhqaBzof1xFbRQXRxAq2dGGiNCyfoqIQ6uvHuHKHXu9uX2UM2f7p_nN3MM8Mw7zKGhcSyNNQqCgVYWfICoGAMDBCpXEmdtYTI3ECpnErOJDVSYi6YFcaWdISut7qr_q1x1ri2C1DrVagaCGvtodJ_b9pqod_9p1aEKypwErjYCQT_0bvY6aaKxtU1tM73UefpKcq4FCKh5__Qpe9Dm8ZLFC8IyyXbCF5uKRN8jMGVv2YI1psk9CYJ_Z1Egs_27f-iP_9OvwCrEoRD</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>Rao, Zhiping</creator><creator>Zhu, Yutong</creator><creator>Yang, Peng</creator><creator>Chen, Zhuang</creator><creator>Xia, Yuqiong</creator><creator>Qiao, Chaoqiang</creator><creator>Liu, Weijing</creator><creator>Deng, Hongzhang</creator><creator>Li, Jianxiong</creator><creator>Ning, Pengbo</creator><creator>Wang, Zhongliang</creator><general>Ivyspring International Publisher Pty Ltd</general><general>Ivyspring International Publisher</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220101</creationdate><title>Pyroptosis in inflammatory diseases and cancer</title><author>Rao, Zhiping ; Zhu, Yutong ; Yang, Peng ; Chen, Zhuang ; Xia, Yuqiong ; Qiao, Chaoqiang ; Liu, Weijing ; Deng, Hongzhang ; Li, Jianxiong ; Ning, Pengbo ; Wang, Zhongliang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-407808fc3d93a5ad8f65aa544aca189ef3edd1182caf9e900483c880674d7cdf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adenosine triphosphate</topic><topic>Apoptosis</topic><topic>Bacteria</topic><topic>Cancer</topic><topic>Cytokines</topic><topic>Gram-negative bacteria</topic><topic>Humans</topic><topic>Inflammasomes - metabolism</topic><topic>Inflammatory diseases</topic><topic>Kinases</topic><topic>Neoplasms</topic><topic>Pathogens</topic><topic>Proteins</topic><topic>Pyroptosis - physiology</topic><topic>Review</topic><topic>Salmonella</topic><topic>Signal Transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rao, Zhiping</creatorcontrib><creatorcontrib>Zhu, Yutong</creatorcontrib><creatorcontrib>Yang, Peng</creatorcontrib><creatorcontrib>Chen, Zhuang</creatorcontrib><creatorcontrib>Xia, Yuqiong</creatorcontrib><creatorcontrib>Qiao, Chaoqiang</creatorcontrib><creatorcontrib>Liu, Weijing</creatorcontrib><creatorcontrib>Deng, Hongzhang</creatorcontrib><creatorcontrib>Li, Jianxiong</creatorcontrib><creatorcontrib>Ning, Pengbo</creatorcontrib><creatorcontrib>Wang, Zhongliang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Theranostics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rao, Zhiping</au><au>Zhu, Yutong</au><au>Yang, Peng</au><au>Chen, Zhuang</au><au>Xia, Yuqiong</au><au>Qiao, Chaoqiang</au><au>Liu, Weijing</au><au>Deng, Hongzhang</au><au>Li, Jianxiong</au><au>Ning, Pengbo</au><au>Wang, Zhongliang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pyroptosis in inflammatory diseases and cancer</atitle><jtitle>Theranostics</jtitle><addtitle>Theranostics</addtitle><date>2022-01-01</date><risdate>2022</risdate><volume>12</volume><issue>9</issue><spage>4310</spage><epage>4329</epage><pages>4310-4329</pages><issn>1838-7640</issn><eissn>1838-7640</eissn><abstract>Pyroptosis is a lytic and inflammatory type of programmed cell death that is usually triggered by inflammasomes and executed by gasdermin proteins. 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| subjects | Adenosine triphosphate Apoptosis Bacteria Cancer Cytokines Gram-negative bacteria Humans Inflammasomes - metabolism Inflammatory diseases Kinases Neoplasms Pathogens Proteins Pyroptosis - physiology Review Salmonella Signal Transduction |
| title | Pyroptosis in inflammatory diseases and cancer |
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