Role of EPO and TCF7L2 Gene Polymorphism Contribution to the Occurrence of Diabetic Retinopathy
Objective: For studying the association of EPO (rs551238), EPO (rs1617640), and TCF7L2 (rs7903146) gene with diabetic retinopathy in Northern Chinese population. Methods: We conducted a case-control study, which enrolled 680 subjects and performed SNP genotyping and calculated allele frequencies. Re...
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| Veröffentlicht in: | Disease markers 2022, Vol.2022, p.6900660-7 |
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| description | Objective: For studying the association of EPO (rs551238), EPO (rs1617640), and TCF7L2 (rs7903146) gene with diabetic retinopathy in Northern Chinese population. Methods: We conducted a case-control study, which enrolled 680 subjects and performed SNP genotyping and calculated allele frequencies. Results: When comparison was performed between DR patients and normal persons, the EPO (rs551238) AA genotype has a significant risk association with DR, and AC genotype has a significant protective association with DR. The EPO (rs551238) A allele has a significant risk association with DR, and C allele has a significant protective association with DR. When comparison was performed between DR patients and DM patients, the EPO (rs551238) CC genotype has a significant protective association with DR; the EPO (rs551238) A allele has a significant risk association with DR; and C allele has a significant protective association with DR. When comparison was performed between DR patients and normal persons, the EPO (rs1617640) GT genotype has a significant protective association with DR, and TT genotype has a significant risk association with DR. The EPO (rs1617640) G allele has a significant protective association with DR, and T allele has a significant risk association with DR. In addition, we found that TT genotype does not exist in rs7903146 of TCF7L2 in Chinese population so that the data could not be used. Conclusions: EPO (rs551238, rs1617640) genotype is a susceptible gene for DR in Chinese type 2 diabetic patients, especially the high-risk PDR. |
| doi_str_mv | 10.1155/2022/6900660 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9168213</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2674752938</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-3d5326ae2caa7bd7c22eb59871b3b11b5496929803e514cde04e480f6ad7a0323</originalsourceid><addsrcrecordid>eNp9kU2LFDEQhoMo7rh68ywBL4K2W_lOLgsy-6EwMMuynkM6nbGzdCdjuluZf789zrioBy9Vh3p4eIsXodcEPhIixBkFSs-kAZASnqAF0UpUWjJ4ihZAla6AcjhBL4bhHoBQw81zdMKEVEoyvUD2NncB5w2-vFljlxp8t7xSK4qvQwr4Jne7PpdtG4ceL3MaS6ynMeaEx4zHNuC191MpIflfiovo6jBGj2_nmfLWje3uJXq2cd0QXh33Kfp6dXm3_Fyt1tdflp9Wlecgxoo1glHpAvXOqbpRntJQC6MVqVlNSC24kYYaDSwIwn0TgAeuYSNdoxwwyk7R-cG7neo-ND7MYV1ntyX2ruxsdtH-fUmxtd_yD2uI1JSwWfDuKCj5-xSG0fZx8KHrXAp5GiyViitBDdMz-vYf9D5PJc3v7SlGqSbAZ-rDgfIlD0MJm8cwBOy-Obtvzh6bm_E3fz7wCP-uagbeH4A2psb9jP_XPQBq-J9e</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2673228104</pqid></control><display><type>article</type><title>Role of EPO and TCF7L2 Gene Polymorphism Contribution to the Occurrence of Diabetic Retinopathy</title><source>MEDLINE</source><source>Wiley Online Library Open Access</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Liu, Chao ; Bai, Ga-Li ; Liu, Ping ; Wang, Lin</creator><contributor>Bian, Yaoyao</contributor><creatorcontrib>Liu, Chao ; Bai, Ga-Li ; Liu, Ping ; Wang, Lin ; Bian, Yaoyao</creatorcontrib><description>Objective: For studying the association of EPO (rs551238), EPO (rs1617640), and TCF7L2 (rs7903146) gene with diabetic retinopathy in Northern Chinese population. Methods: We conducted a case-control study, which enrolled 680 subjects and performed SNP genotyping and calculated allele frequencies. Results: When comparison was performed between DR patients and normal persons, the EPO (rs551238) AA genotype has a significant risk association with DR, and AC genotype has a significant protective association with DR. The EPO (rs551238) A allele has a significant risk association with DR, and C allele has a significant protective association with DR. When comparison was performed between DR patients and DM patients, the EPO (rs551238) CC genotype has a significant protective association with DR; the EPO (rs551238) A allele has a significant risk association with DR; and C allele has a significant protective association with DR. When comparison was performed between DR patients and normal persons, the EPO (rs1617640) GT genotype has a significant protective association with DR, and TT genotype has a significant risk association with DR. The EPO (rs1617640) G allele has a significant protective association with DR, and T allele has a significant risk association with DR. In addition, we found that TT genotype does not exist in rs7903146 of TCF7L2 in Chinese population so that the data could not be used. Conclusions: EPO (rs551238, rs1617640) genotype is a susceptible gene for DR in Chinese type 2 diabetic patients, especially the high-risk PDR.</description><identifier>ISSN: 0278-0240</identifier><identifier>EISSN: 1875-8630</identifier><identifier>DOI: 10.1155/2022/6900660</identifier><identifier>PMID: 35677638</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Alleles ; Asians - genetics ; Case-Control Studies ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Type 2 - genetics ; Diabetic retinopathy ; Diabetic Retinopathy - genetics ; Disease ; Gene Frequency ; Gene polymorphism ; Genes ; Genetic Predisposition to Disease ; Genotype ; Genotype & phenotype ; Genotyping ; Glaucoma ; Hemorrhage ; Hospitals ; Humans ; Hypoxia ; Polymorphism ; Polymorphism, Single Nucleotide ; Retinopathy ; Risk ; Single-nucleotide polymorphism ; Transcription Factor 7-Like 2 Protein - genetics</subject><ispartof>Disease markers, 2022, Vol.2022, p.6900660-7</ispartof><rights>Copyright © 2022 Chao Liu et al.</rights><rights>Copyright © 2022 Chao Liu et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2022 Chao Liu et al. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c405t-3d5326ae2caa7bd7c22eb59871b3b11b5496929803e514cde04e480f6ad7a0323</cites><orcidid>0000-0003-1278-1070 ; 0000-0001-9762-4212</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168213/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168213/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35677638$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Bian, Yaoyao</contributor><creatorcontrib>Liu, Chao</creatorcontrib><creatorcontrib>Bai, Ga-Li</creatorcontrib><creatorcontrib>Liu, Ping</creatorcontrib><creatorcontrib>Wang, Lin</creatorcontrib><title>Role of EPO and TCF7L2 Gene Polymorphism Contribution to the Occurrence of Diabetic Retinopathy</title><title>Disease markers</title><addtitle>Dis Markers</addtitle><description>Objective: For studying the association of EPO (rs551238), EPO (rs1617640), and TCF7L2 (rs7903146) gene with diabetic retinopathy in Northern Chinese population. Methods: We conducted a case-control study, which enrolled 680 subjects and performed SNP genotyping and calculated allele frequencies. Results: When comparison was performed between DR patients and normal persons, the EPO (rs551238) AA genotype has a significant risk association with DR, and AC genotype has a significant protective association with DR. The EPO (rs551238) A allele has a significant risk association with DR, and C allele has a significant protective association with DR. When comparison was performed between DR patients and DM patients, the EPO (rs551238) CC genotype has a significant protective association with DR; the EPO (rs551238) A allele has a significant risk association with DR; and C allele has a significant protective association with DR. When comparison was performed between DR patients and normal persons, the EPO (rs1617640) GT genotype has a significant protective association with DR, and TT genotype has a significant risk association with DR. The EPO (rs1617640) G allele has a significant protective association with DR, and T allele has a significant risk association with DR. In addition, we found that TT genotype does not exist in rs7903146 of TCF7L2 in Chinese population so that the data could not be used. Conclusions: EPO (rs551238, rs1617640) genotype is a susceptible gene for DR in Chinese type 2 diabetic patients, especially the high-risk PDR.</description><subject>Alleles</subject><subject>Asians - genetics</subject><subject>Case-Control Studies</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Diabetic retinopathy</subject><subject>Diabetic Retinopathy - genetics</subject><subject>Disease</subject><subject>Gene Frequency</subject><subject>Gene polymorphism</subject><subject>Genes</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Genotyping</subject><subject>Glaucoma</subject><subject>Hemorrhage</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Retinopathy</subject><subject>Risk</subject><subject>Single-nucleotide polymorphism</subject><subject>Transcription Factor 7-Like 2 Protein - genetics</subject><issn>0278-0240</issn><issn>1875-8630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><recordid>eNp9kU2LFDEQhoMo7rh68ywBL4K2W_lOLgsy-6EwMMuynkM6nbGzdCdjuluZf789zrioBy9Vh3p4eIsXodcEPhIixBkFSs-kAZASnqAF0UpUWjJ4ihZAla6AcjhBL4bhHoBQw81zdMKEVEoyvUD2NncB5w2-vFljlxp8t7xSK4qvQwr4Jne7PpdtG4ceL3MaS6ynMeaEx4zHNuC191MpIflfiovo6jBGj2_nmfLWje3uJXq2cd0QXh33Kfp6dXm3_Fyt1tdflp9Wlecgxoo1glHpAvXOqbpRntJQC6MVqVlNSC24kYYaDSwIwn0TgAeuYSNdoxwwyk7R-cG7neo-ND7MYV1ntyX2ruxsdtH-fUmxtd_yD2uI1JSwWfDuKCj5-xSG0fZx8KHrXAp5GiyViitBDdMz-vYf9D5PJc3v7SlGqSbAZ-rDgfIlD0MJm8cwBOy-Obtvzh6bm_E3fz7wCP-uagbeH4A2psb9jP_XPQBq-J9e</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>Liu, Chao</creator><creator>Bai, Ga-Li</creator><creator>Liu, Ping</creator><creator>Wang, Lin</creator><general>Hindawi</general><general>Hindawi Limited</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1278-1070</orcidid><orcidid>https://orcid.org/0000-0001-9762-4212</orcidid></search><sort><creationdate>2022</creationdate><title>Role of EPO and TCF7L2 Gene Polymorphism Contribution to the Occurrence of Diabetic Retinopathy</title><author>Liu, Chao ; Bai, Ga-Li ; Liu, Ping ; Wang, Lin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-3d5326ae2caa7bd7c22eb59871b3b11b5496929803e514cde04e480f6ad7a0323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Alleles</topic><topic>Asians - genetics</topic><topic>Case-Control Studies</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Diabetic retinopathy</topic><topic>Diabetic Retinopathy - genetics</topic><topic>Disease</topic><topic>Gene Frequency</topic><topic>Gene polymorphism</topic><topic>Genes</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Genotyping</topic><topic>Glaucoma</topic><topic>Hemorrhage</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypoxia</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Retinopathy</topic><topic>Risk</topic><topic>Single-nucleotide polymorphism</topic><topic>Transcription Factor 7-Like 2 Protein - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Chao</creatorcontrib><creatorcontrib>Bai, Ga-Li</creatorcontrib><creatorcontrib>Liu, Ping</creatorcontrib><creatorcontrib>Wang, Lin</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Disease markers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Chao</au><au>Bai, Ga-Li</au><au>Liu, Ping</au><au>Wang, Lin</au><au>Bian, Yaoyao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of EPO and TCF7L2 Gene Polymorphism Contribution to the Occurrence of Diabetic Retinopathy</atitle><jtitle>Disease markers</jtitle><addtitle>Dis Markers</addtitle><date>2022</date><risdate>2022</risdate><volume>2022</volume><spage>6900660</spage><epage>7</epage><pages>6900660-7</pages><issn>0278-0240</issn><eissn>1875-8630</eissn><abstract>Objective: For studying the association of EPO (rs551238), EPO (rs1617640), and TCF7L2 (rs7903146) gene with diabetic retinopathy in Northern Chinese population. Methods: We conducted a case-control study, which enrolled 680 subjects and performed SNP genotyping and calculated allele frequencies. Results: When comparison was performed between DR patients and normal persons, the EPO (rs551238) AA genotype has a significant risk association with DR, and AC genotype has a significant protective association with DR. The EPO (rs551238) A allele has a significant risk association with DR, and C allele has a significant protective association with DR. When comparison was performed between DR patients and DM patients, the EPO (rs551238) CC genotype has a significant protective association with DR; the EPO (rs551238) A allele has a significant risk association with DR; and C allele has a significant protective association with DR. When comparison was performed between DR patients and normal persons, the EPO (rs1617640) GT genotype has a significant protective association with DR, and TT genotype has a significant risk association with DR. The EPO (rs1617640) G allele has a significant protective association with DR, and T allele has a significant risk association with DR. In addition, we found that TT genotype does not exist in rs7903146 of TCF7L2 in Chinese population so that the data could not be used. Conclusions: EPO (rs551238, rs1617640) genotype is a susceptible gene for DR in Chinese type 2 diabetic patients, especially the high-risk PDR.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>35677638</pmid><doi>10.1155/2022/6900660</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-1278-1070</orcidid><orcidid>https://orcid.org/0000-0001-9762-4212</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Alleles Asians - genetics Case-Control Studies Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - genetics Diabetic retinopathy Diabetic Retinopathy - genetics Disease Gene Frequency Gene polymorphism Genes Genetic Predisposition to Disease Genotype Genotype & phenotype Genotyping Glaucoma Hemorrhage Hospitals Humans Hypoxia Polymorphism Polymorphism, Single Nucleotide Retinopathy Risk Single-nucleotide polymorphism Transcription Factor 7-Like 2 Protein - genetics |
| title | Role of EPO and TCF7L2 Gene Polymorphism Contribution to the Occurrence of Diabetic Retinopathy |
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