Theranostic PSMA ligands with optimized backbones for intraoperative multimodal imaging and photodynamic therapy of prostate cancer

Introduction The first generation ligands for prostate-specific membrane antigen (PSMA)–targeted radio- and fluorescence-guided surgery followed by adjuvant photodynamic therapy (PDT) have already shown the potential of this approach. Here, we developed three new photosensitizer-based dual-labeled...

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Veröffentlicht in:	European journal of nuclear medicine and molecular imaging 2022-06, Vol.49 (7), p.2425-2435
Hauptverfasser:	Derks, Yvonne H. W., van Lith, Sanne A. M., Amatdjais-Groenen, Helene I. V., Wouters, Lieke W. M., Kip, Annemarie, Franssen, Gerben M., Laverman, Peter, Löwik, Dennis W. P. M., Heskamp, Sandra, Rijpkema, Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Animals Antigens Antigens, Surface - metabolism Backbone Cardiology Cell Line, Tumor Cell viability Chemical synthesis Computed tomography Conjugation Fluorescence Glutamate Carboxypeptidase II - metabolism Glutamic acid Humans Imaging Ligands Lysine Male Medical imaging Medicine Medicine & Public Health Mice Mice, Nude Multimodal Imaging Nuclear Medicine Oncology Oncology – Genitourinary Optimization Original Original Article Orthopedics Photochemotherapy Photodynamic therapy Photosensitizing Agents - therapeutic use Precision Medicine Prostate Prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - therapy Radioisotopes Radiology Solid phases Surgery Tissue Distribution Tumors
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