Maternal Exercise-Induced SOD3 Reverses the Deleterious Effects of Maternal High-Fat Diet on Offspring Metabolism Through Stabilization of H3K4me3 and Protection Against WDR82 Carbonylation

Preclinical studies reveal maternal exercise as a promising intervention to reduce the transmission of multigenerational metabolic dysfunction caused by maternal obesity. The benefits of maternal exercise on offspring health may arise from multiple factors and have recently been shown to involve DNA...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2022-06, Vol.71 (6), p.1170-1181
Hauptverfasser:	Kusuyama, Joji, Makarewicz, Nathan S, Albertson, Brent G, Alves-Wagner, Ana Barbara, Conlin, Royce H, Prince, Noah B, Alves, Christiano R R, Ramachandran, Krithika, Kozuka, Chisayo, Xiudong, Yang, Xia, Yang, Hirshman, Michael F, Hatta, Toshihisa, Nagatomi, Ryoichi, Nozik, Eva S, Goodyear, Laurie J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine Animals Antioxidants Chromosomal Proteins, Non-Histone - metabolism Demethylation Diabetes Diet, High-Fat Epigenetics Exercise Fat metabolism Female Fetuses Gene expression Glucose Glucose - metabolism High fat diet Histone H3 Histones Histones - metabolism Humans Liver Lysine Metabolism Methylation Methyltransferase Mice Mice, Inbred C57BL Obesity Obesity, Maternal Offspring Placenta - metabolism Pregnancy Prenatal Exposure Delayed Effects - metabolism Reactive oxygen species Superoxide dismutase Superoxide Dismutase - genetics Superoxide Dismutase - metabolism
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