Immunostimulatory Cancer-Associated Fibroblast Subpopulations Can Predict Immunotherapy Response in Head and Neck Cancer

Cancer-associated fibroblasts (CAF) have been implicated as potential mediators of checkpoint immunotherapy response. However, the extensive heterogeneity of these cells has precluded rigorous understanding of their immunoregulatory role in the tumor microenvironment. We performed high-dimensional s...

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Veröffentlicht in:	Clinical cancer research 2022-05, Vol.28 (10), p.2094-2109
Hauptverfasser:	Obradovic, Aleksandar, Graves, Diana, Korrer, Michael, Wang, Yu, Roy, Sohini, Naveed, Abdullah, Xu, Yaomin, Luginbuhl, Adam, Curry, Joseph, Gibson, Michael, Idrees, Kamran, Hurley, Paula, Jiang, Peng, Liu, X Shirley, Uppaluri, Ravindra, Drake, Charles G, Califano, Andrea, Kim, Young J
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer-Associated Fibroblasts Head and Neck Neoplasms - drug therapy Humans Immunotherapy - methods Nivolumab - therapeutic use Squamous Cell Carcinoma of Head and Neck - drug therapy Tumor Microenvironment
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