Relative Trajectories of Gait and Cognitive Decline in Aging
Abstract Background Gait and cognition decline with advancing age, and presage the onset of dementia. Yet, the relative trajectories of gait and cognitive decline in aging are poorly understood—particularly among those with the motoric cognitive risk (MCR) syndrome. This study compared changes in si...
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| Veröffentlicht in: | The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2022-06, Vol.77 (6), p.1230-1238 |
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| container_title | The journals of gerontology. Series A, Biological sciences and medical sciences |
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| creator | Jayakody, Oshadi Breslin, Monique Ayers, Emmeline Verghese, Joe Barzilai, Nir Milman, Sofiya Weiss, Erica Blumen, Helena M |
| description | Abstract
Background
Gait and cognition decline with advancing age, and presage the onset of dementia. Yet, the relative trajectories of gait and cognitive decline in aging are poorly understood—particularly among those with the motoric cognitive risk (MCR) syndrome. This study compared changes in simple and complex gait performance and cognition, as a function of age and MCR.
Methods
We examined gait and cognitive functions of 1 095 LonGenity study participants (mean age = 75.4 ± 6.7 years) with up to 12 years of annual follow-up. Participants were of Ashkenazi Jewish descent, free of dementia, ambulatory, and had a 12.2% MCR prevalence at baseline. Gait speed was measured at usual pace walking (single-task walking, STW-speed) and walking while talking (WWT-speed). Eleven neuropsychological test scores were examined separately, and as a global cognition composite. Linear mixed-effects models adjusted for baseline sex, education, parental longevity, cognitive impairment, and global health were used to estimate changes in gait and cognition, as a function of age and MCR.
Results
STW-speed, WWT-speed, and cognitive tests performance declined in a nonlinear (accelerating) fashion with age. STW-speed declined faster than WWT-speed and cognitive test scores. People with MCR showed faster rates of decline on figure copy and phonemic fluency.
Conclusions
Gait declines at a faster rate than cognition in aging. People with MCR are susceptible to faster decline in visuospatial, executive, and language functions. This study adds important knowledge of trajectories of gait and cognitive decline in aging, and identifies MCR as a risk factor for accelerated cognitive decline. |
| doi_str_mv | 10.1093/gerona/glab346 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9159658</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/gerona/glab346</oup_id><sourcerecordid>2674046861</sourcerecordid><originalsourceid>FETCH-LOGICAL-c452t-ab0517ab117abd77e3fd3911bfa8aea5c765b73233fc7b876dd95d24e8da385e3</originalsourceid><addsrcrecordid>eNqFkU1LxDAQhoMofl89SsGLHqpJ0zQNiCCrrsKCIArewrSd1izdZE1awX9v111FvZjDZGCeeZmZl5ADRk8ZVfysQe8snDUtFDzN1sg2kyKPBRfP60NOpYoFpdkW2QlhShdPJJtki6dSsYSrbXL-gC105g2jRw9TLDvnDYbI1dEYTBeBraKRa6z5RK6wbI3FyNjosjG22SMbNbQB91f_Lnm6uX4c3caT-_Hd6HISl6lIuhgKKpiEgi1CJSXyuuKKsaKGHBBEKTNRSJ5wXpeyyGVWVUpUSYp5BTwXyHfJxVJ33hczrEq0nYdWz72ZgX_XDoz-XbHmRTfuTSsmVCbyQeB4JeDda4-h0zMTSmxbsOj6oBOhFJXDdeSAHv1Bp673dlhPJ5lMaZrlGRuo0yVVeheCx_p7GEb1whi9NEavjBkaDn-u8I1_OTEAJ0vA9fP_xD4AFjWaHw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2674046861</pqid></control><display><type>article</type><title>Relative Trajectories of Gait and Cognitive Decline in Aging</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Alma/SFX Local Collection</source><creator>Jayakody, Oshadi ; Breslin, Monique ; Ayers, Emmeline ; Verghese, Joe ; Barzilai, Nir ; Milman, Sofiya ; Weiss, Erica ; Blumen, Helena M</creator><contributor>Fielding, Roger A</contributor><creatorcontrib>Jayakody, Oshadi ; Breslin, Monique ; Ayers, Emmeline ; Verghese, Joe ; Barzilai, Nir ; Milman, Sofiya ; Weiss, Erica ; Blumen, Helena M ; Fielding, Roger A</creatorcontrib><description>Abstract
Background
Gait and cognition decline with advancing age, and presage the onset of dementia. Yet, the relative trajectories of gait and cognitive decline in aging are poorly understood—particularly among those with the motoric cognitive risk (MCR) syndrome. This study compared changes in simple and complex gait performance and cognition, as a function of age and MCR.
Methods
We examined gait and cognitive functions of 1 095 LonGenity study participants (mean age = 75.4 ± 6.7 years) with up to 12 years of annual follow-up. Participants were of Ashkenazi Jewish descent, free of dementia, ambulatory, and had a 12.2% MCR prevalence at baseline. Gait speed was measured at usual pace walking (single-task walking, STW-speed) and walking while talking (WWT-speed). Eleven neuropsychological test scores were examined separately, and as a global cognition composite. Linear mixed-effects models adjusted for baseline sex, education, parental longevity, cognitive impairment, and global health were used to estimate changes in gait and cognition, as a function of age and MCR.
Results
STW-speed, WWT-speed, and cognitive tests performance declined in a nonlinear (accelerating) fashion with age. STW-speed declined faster than WWT-speed and cognitive test scores. People with MCR showed faster rates of decline on figure copy and phonemic fluency.
Conclusions
Gait declines at a faster rate than cognition in aging. People with MCR are susceptible to faster decline in visuospatial, executive, and language functions. This study adds important knowledge of trajectories of gait and cognitive decline in aging, and identifies MCR as a risk factor for accelerated cognitive decline.</description><identifier>ISSN: 1079-5006</identifier><identifier>EISSN: 1758-535X</identifier><identifier>DOI: 10.1093/gerona/glab346</identifier><identifier>PMID: 34791239</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Aged ; Aged, 80 and over ; Aging ; Aging - psychology ; Cognition ; Cognition & reasoning ; Cognitive ability ; Cognitive Dysfunction - epidemiology ; Dementia ; Dementia disorders ; Editor's Choice ; Gait ; Humans ; Neuropsychological Tests ; Public health ; Risk factors ; THE JOURNAL OF GERONTOLOGY: Medical Sciences ; Walking</subject><ispartof>The journals of gerontology. Series A, Biological sciences and medical sciences, 2022-06, Vol.77 (6), p.1230-1238</ispartof><rights>The Author(s) 2021. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. 2021</rights><rights>The Author(s) 2021. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><rights>Copyright Oxford University Press Jun 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-ab0517ab117abd77e3fd3911bfa8aea5c765b73233fc7b876dd95d24e8da385e3</citedby><cites>FETCH-LOGICAL-c452t-ab0517ab117abd77e3fd3911bfa8aea5c765b73233fc7b876dd95d24e8da385e3</cites><orcidid>0000-0002-7787-6268 ; 0000-0001-5220-4927</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,1584,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34791239$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Fielding, Roger A</contributor><creatorcontrib>Jayakody, Oshadi</creatorcontrib><creatorcontrib>Breslin, Monique</creatorcontrib><creatorcontrib>Ayers, Emmeline</creatorcontrib><creatorcontrib>Verghese, Joe</creatorcontrib><creatorcontrib>Barzilai, Nir</creatorcontrib><creatorcontrib>Milman, Sofiya</creatorcontrib><creatorcontrib>Weiss, Erica</creatorcontrib><creatorcontrib>Blumen, Helena M</creatorcontrib><title>Relative Trajectories of Gait and Cognitive Decline in Aging</title><title>The journals of gerontology. Series A, Biological sciences and medical sciences</title><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><description>Abstract
Background
Gait and cognition decline with advancing age, and presage the onset of dementia. Yet, the relative trajectories of gait and cognitive decline in aging are poorly understood—particularly among those with the motoric cognitive risk (MCR) syndrome. This study compared changes in simple and complex gait performance and cognition, as a function of age and MCR.
Methods
We examined gait and cognitive functions of 1 095 LonGenity study participants (mean age = 75.4 ± 6.7 years) with up to 12 years of annual follow-up. Participants were of Ashkenazi Jewish descent, free of dementia, ambulatory, and had a 12.2% MCR prevalence at baseline. Gait speed was measured at usual pace walking (single-task walking, STW-speed) and walking while talking (WWT-speed). Eleven neuropsychological test scores were examined separately, and as a global cognition composite. Linear mixed-effects models adjusted for baseline sex, education, parental longevity, cognitive impairment, and global health were used to estimate changes in gait and cognition, as a function of age and MCR.
Results
STW-speed, WWT-speed, and cognitive tests performance declined in a nonlinear (accelerating) fashion with age. STW-speed declined faster than WWT-speed and cognitive test scores. People with MCR showed faster rates of decline on figure copy and phonemic fluency.
Conclusions
Gait declines at a faster rate than cognition in aging. People with MCR are susceptible to faster decline in visuospatial, executive, and language functions. This study adds important knowledge of trajectories of gait and cognitive decline in aging, and identifies MCR as a risk factor for accelerated cognitive decline.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Aging - psychology</subject><subject>Cognition</subject><subject>Cognition & reasoning</subject><subject>Cognitive ability</subject><subject>Cognitive Dysfunction - epidemiology</subject><subject>Dementia</subject><subject>Dementia disorders</subject><subject>Editor's Choice</subject><subject>Gait</subject><subject>Humans</subject><subject>Neuropsychological Tests</subject><subject>Public health</subject><subject>Risk factors</subject><subject>THE JOURNAL OF GERONTOLOGY: Medical Sciences</subject><subject>Walking</subject><issn>1079-5006</issn><issn>1758-535X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1LxDAQhoMofl89SsGLHqpJ0zQNiCCrrsKCIArewrSd1izdZE1awX9v111FvZjDZGCeeZmZl5ADRk8ZVfysQe8snDUtFDzN1sg2kyKPBRfP60NOpYoFpdkW2QlhShdPJJtki6dSsYSrbXL-gC105g2jRw9TLDvnDYbI1dEYTBeBraKRa6z5RK6wbI3FyNjosjG22SMbNbQB91f_Lnm6uX4c3caT-_Hd6HISl6lIuhgKKpiEgi1CJSXyuuKKsaKGHBBEKTNRSJ5wXpeyyGVWVUpUSYp5BTwXyHfJxVJ33hczrEq0nYdWz72ZgX_XDoz-XbHmRTfuTSsmVCbyQeB4JeDda4-h0zMTSmxbsOj6oBOhFJXDdeSAHv1Bp673dlhPJ5lMaZrlGRuo0yVVeheCx_p7GEb1whi9NEavjBkaDn-u8I1_OTEAJ0vA9fP_xD4AFjWaHw</recordid><startdate>20220601</startdate><enddate>20220601</enddate><creator>Jayakody, Oshadi</creator><creator>Breslin, Monique</creator><creator>Ayers, Emmeline</creator><creator>Verghese, Joe</creator><creator>Barzilai, Nir</creator><creator>Milman, Sofiya</creator><creator>Weiss, Erica</creator><creator>Blumen, Helena M</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7787-6268</orcidid><orcidid>https://orcid.org/0000-0001-5220-4927</orcidid></search><sort><creationdate>20220601</creationdate><title>Relative Trajectories of Gait and Cognitive Decline in Aging</title><author>Jayakody, Oshadi ; Breslin, Monique ; Ayers, Emmeline ; Verghese, Joe ; Barzilai, Nir ; Milman, Sofiya ; Weiss, Erica ; Blumen, Helena M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-ab0517ab117abd77e3fd3911bfa8aea5c765b73233fc7b876dd95d24e8da385e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Aging - psychology</topic><topic>Cognition</topic><topic>Cognition & reasoning</topic><topic>Cognitive ability</topic><topic>Cognitive Dysfunction - epidemiology</topic><topic>Dementia</topic><topic>Dementia disorders</topic><topic>Editor's Choice</topic><topic>Gait</topic><topic>Humans</topic><topic>Neuropsychological Tests</topic><topic>Public health</topic><topic>Risk factors</topic><topic>THE JOURNAL OF GERONTOLOGY: Medical Sciences</topic><topic>Walking</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jayakody, Oshadi</creatorcontrib><creatorcontrib>Breslin, Monique</creatorcontrib><creatorcontrib>Ayers, Emmeline</creatorcontrib><creatorcontrib>Verghese, Joe</creatorcontrib><creatorcontrib>Barzilai, Nir</creatorcontrib><creatorcontrib>Milman, Sofiya</creatorcontrib><creatorcontrib>Weiss, Erica</creatorcontrib><creatorcontrib>Blumen, Helena M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journals of gerontology. Series A, Biological sciences and medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jayakody, Oshadi</au><au>Breslin, Monique</au><au>Ayers, Emmeline</au><au>Verghese, Joe</au><au>Barzilai, Nir</au><au>Milman, Sofiya</au><au>Weiss, Erica</au><au>Blumen, Helena M</au><au>Fielding, Roger A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relative Trajectories of Gait and Cognitive Decline in Aging</atitle><jtitle>The journals of gerontology. Series A, Biological sciences and medical sciences</jtitle><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><date>2022-06-01</date><risdate>2022</risdate><volume>77</volume><issue>6</issue><spage>1230</spage><epage>1238</epage><pages>1230-1238</pages><issn>1079-5006</issn><eissn>1758-535X</eissn><abstract>Abstract
Background
Gait and cognition decline with advancing age, and presage the onset of dementia. Yet, the relative trajectories of gait and cognitive decline in aging are poorly understood—particularly among those with the motoric cognitive risk (MCR) syndrome. This study compared changes in simple and complex gait performance and cognition, as a function of age and MCR.
Methods
We examined gait and cognitive functions of 1 095 LonGenity study participants (mean age = 75.4 ± 6.7 years) with up to 12 years of annual follow-up. Participants were of Ashkenazi Jewish descent, free of dementia, ambulatory, and had a 12.2% MCR prevalence at baseline. Gait speed was measured at usual pace walking (single-task walking, STW-speed) and walking while talking (WWT-speed). Eleven neuropsychological test scores were examined separately, and as a global cognition composite. Linear mixed-effects models adjusted for baseline sex, education, parental longevity, cognitive impairment, and global health were used to estimate changes in gait and cognition, as a function of age and MCR.
Results
STW-speed, WWT-speed, and cognitive tests performance declined in a nonlinear (accelerating) fashion with age. STW-speed declined faster than WWT-speed and cognitive test scores. People with MCR showed faster rates of decline on figure copy and phonemic fluency.
Conclusions
Gait declines at a faster rate than cognition in aging. People with MCR are susceptible to faster decline in visuospatial, executive, and language functions. This study adds important knowledge of trajectories of gait and cognitive decline in aging, and identifies MCR as a risk factor for accelerated cognitive decline.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>34791239</pmid><doi>10.1093/gerona/glab346</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-7787-6268</orcidid><orcidid>https://orcid.org/0000-0001-5220-4927</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | The journals of gerontology. Series A, Biological sciences and medical sciences, 2022-06, Vol.77 (6), p.1230-1238 |
| issn | 1079-5006 1758-535X |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Aged Aged, 80 and over Aging Aging - psychology Cognition Cognition & reasoning Cognitive ability Cognitive Dysfunction - epidemiology Dementia Dementia disorders Editor's Choice Gait Humans Neuropsychological Tests Public health Risk factors THE JOURNAL OF GERONTOLOGY: Medical Sciences Walking |
| title | Relative Trajectories of Gait and Cognitive Decline in Aging |
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