Relationship Between 18F-Flortaucipir Uptake and Histologic Lesion Types in 4-Repeat Tauopathies
Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are 4-repeat (4R) tauopathies with overlapping, but also morphologically distinct, tau immunoreactive lesions that vary in count by brain region. 18F-flortaucipir PET uptake has been reported to correlate with overall tau burde...
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| Veröffentlicht in: | The Journal of nuclear medicine (1978) 2022-06, Vol.63 (6), p.931-935 |
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| container_title | The Journal of nuclear medicine (1978) |
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| creator | Josephs, Keith A Tosakulwong, Nirubol Weigand, Stephen D Buciuc, Marina Lowe, Val J Dickson, Dennis W Whitwell, Jennifer L |
| description | Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are 4-repeat (4R) tauopathies with overlapping, but also morphologically distinct, tau immunoreactive lesions that vary in count by brain region. 18F-flortaucipir PET uptake has been reported to correlate with overall tau burden, and-in 1 CBD case-to have greater affinity to threads than tangles. We determined whether 18F-flortaucipir uptake is associated with histologic lesion type in 4R tauopathies. Methods: We performed semiquantitative regional lesion counts on pretangles/neurofibrillary tangles, threads, oligodendroglial coiled bodies, tufted astrocytes, and astrocytic plaques in 29 cases of autopsied 4R tauopathy (PSP, 16; CBD, 13). Regression models were used for statistical analyses. Results: 18F-flortaucipir uptake marginally correlated with threads in the precentral cortex (P = 0.04) and with astrocytic lesions in the red nucleus (P = 0.05). Conclusion: The findings do not support 18F-flortaucipir's having differential affinity to any 4R tau lesion type. |
| doi_str_mv | 10.2967/jnumed.121.262685 |
| format | Article |
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We determined whether 18F-flortaucipir uptake is associated with histologic lesion type in 4R tauopathies. Methods: We performed semiquantitative regional lesion counts on pretangles/neurofibrillary tangles, threads, oligodendroglial coiled bodies, tufted astrocytes, and astrocytic plaques in 29 cases of autopsied 4R tauopathy (PSP, 16; CBD, 13). Regression models were used for statistical analyses. Results: 18F-flortaucipir uptake marginally correlated with threads in the precentral cortex (P = 0.04) and with astrocytic lesions in the red nucleus (P = 0.05). Conclusion: The findings do not support 18F-flortaucipir's having differential affinity to any 4R tau lesion type.</description><identifier>ISSN: 0161-5505</identifier><identifier>EISSN: 1535-5667</identifier><identifier>DOI: 10.2967/jnumed.121.262685</identifier><identifier>PMID: 34556525</identifier><language>eng</language><publisher>New York: Society of Nuclear Medicine</publisher><subject>Affinity ; Astrocytes ; Autopsies ; Brief Communication ; Degeneration ; Lesions ; Neurodegeneration ; Neurodegenerative diseases ; Neurofibrillary tangles ; Paralysis ; Plaques ; Positron emission tomography ; Progressive supranuclear palsy ; Red nucleus ; Regression analysis ; Regression models ; Statistical analysis ; Tau protein</subject><ispartof>The Journal of nuclear medicine (1978), 2022-06, Vol.63 (6), p.931-935</ispartof><rights>Copyright Society of Nuclear Medicine Jun 1, 2022</rights><rights>2022 by the Society of Nuclear Medicine and Molecular Imaging. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,781,785,886,27929,27930</link.rule.ids></links><search><creatorcontrib>Josephs, Keith A</creatorcontrib><creatorcontrib>Tosakulwong, Nirubol</creatorcontrib><creatorcontrib>Weigand, Stephen D</creatorcontrib><creatorcontrib>Buciuc, Marina</creatorcontrib><creatorcontrib>Lowe, Val J</creatorcontrib><creatorcontrib>Dickson, Dennis W</creatorcontrib><creatorcontrib>Whitwell, Jennifer L</creatorcontrib><title>Relationship Between 18F-Flortaucipir Uptake and Histologic Lesion Types in 4-Repeat Tauopathies</title><title>The Journal of nuclear medicine (1978)</title><description>Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are 4-repeat (4R) tauopathies with overlapping, but also morphologically distinct, tau immunoreactive lesions that vary in count by brain region. 18F-flortaucipir PET uptake has been reported to correlate with overall tau burden, and-in 1 CBD case-to have greater affinity to threads than tangles. We determined whether 18F-flortaucipir uptake is associated with histologic lesion type in 4R tauopathies. Methods: We performed semiquantitative regional lesion counts on pretangles/neurofibrillary tangles, threads, oligodendroglial coiled bodies, tufted astrocytes, and astrocytic plaques in 29 cases of autopsied 4R tauopathy (PSP, 16; CBD, 13). Regression models were used for statistical analyses. Results: 18F-flortaucipir uptake marginally correlated with threads in the precentral cortex (P = 0.04) and with astrocytic lesions in the red nucleus (P = 0.05). Conclusion: The findings do not support 18F-flortaucipir's having differential affinity to any 4R tau lesion type.</description><subject>Affinity</subject><subject>Astrocytes</subject><subject>Autopsies</subject><subject>Brief Communication</subject><subject>Degeneration</subject><subject>Lesions</subject><subject>Neurodegeneration</subject><subject>Neurodegenerative diseases</subject><subject>Neurofibrillary tangles</subject><subject>Paralysis</subject><subject>Plaques</subject><subject>Positron emission tomography</subject><subject>Progressive supranuclear palsy</subject><subject>Red nucleus</subject><subject>Regression analysis</subject><subject>Regression models</subject><subject>Statistical analysis</subject><subject>Tau protein</subject><issn>0161-5505</issn><issn>1535-5667</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpdkEFP3DAQha2qVVlof0BvlrhwyRKPM7ZzQSqIBaSVkNByTmcdh_U2a6exA-LfEwku9DSH971PesPYL1EuoVb6fB-mg2uXAsQSFCiDX9hCoMQCldJf2aIUShSIJR6x45T2ZVkqY8x3diQrRIWAC_bnwfWUfQxp5wd-6fKLc4ELsypWfRwzTdYPfuSPQ6a_jlNo-a1POfbxyVu-dmlu8s3r4BL3gVfFgxscZb6hKQ6Ud96lH-xbR31yPz_uCXtcXW-ubov1_c3d1e91sQdALDqrRNURagm2I7OtaqoIpJIdyUpotYVOWGprVbdStZ2c2VobaDVoNNaCPGEX795h2s5PsS7kkfpmGP2Bxtcmkm8-J8Hvmqf43NQCtQYxC84-BGP8N7mUm4NP1vU9BRen1ABqpdBIMDN6-h-6j9MY5nkNKF1VEspZ-AaFH36E</recordid><startdate>20220601</startdate><enddate>20220601</enddate><creator>Josephs, Keith A</creator><creator>Tosakulwong, Nirubol</creator><creator>Weigand, Stephen D</creator><creator>Buciuc, Marina</creator><creator>Lowe, Val J</creator><creator>Dickson, Dennis W</creator><creator>Whitwell, Jennifer L</creator><general>Society of Nuclear Medicine</general><scope>4T-</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220601</creationdate><title>Relationship Between 18F-Flortaucipir Uptake and Histologic Lesion Types in 4-Repeat Tauopathies</title><author>Josephs, Keith A ; Tosakulwong, Nirubol ; Weigand, Stephen D ; Buciuc, Marina ; Lowe, Val J ; Dickson, Dennis W ; Whitwell, Jennifer L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j2255-fc614fa5732cfa8b49a4a2363fa34176b2f1cad969d36df34fa9782d72758cc23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Affinity</topic><topic>Astrocytes</topic><topic>Autopsies</topic><topic>Brief Communication</topic><topic>Degeneration</topic><topic>Lesions</topic><topic>Neurodegeneration</topic><topic>Neurodegenerative diseases</topic><topic>Neurofibrillary tangles</topic><topic>Paralysis</topic><topic>Plaques</topic><topic>Positron emission tomography</topic><topic>Progressive supranuclear palsy</topic><topic>Red nucleus</topic><topic>Regression analysis</topic><topic>Regression models</topic><topic>Statistical analysis</topic><topic>Tau protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Josephs, Keith A</creatorcontrib><creatorcontrib>Tosakulwong, Nirubol</creatorcontrib><creatorcontrib>Weigand, Stephen D</creatorcontrib><creatorcontrib>Buciuc, Marina</creatorcontrib><creatorcontrib>Lowe, Val J</creatorcontrib><creatorcontrib>Dickson, Dennis W</creatorcontrib><creatorcontrib>Whitwell, Jennifer L</creatorcontrib><collection>Docstoc</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of nuclear medicine (1978)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Josephs, Keith A</au><au>Tosakulwong, Nirubol</au><au>Weigand, Stephen D</au><au>Buciuc, Marina</au><au>Lowe, Val J</au><au>Dickson, Dennis W</au><au>Whitwell, Jennifer L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship Between 18F-Flortaucipir Uptake and Histologic Lesion Types in 4-Repeat Tauopathies</atitle><jtitle>The Journal of nuclear medicine (1978)</jtitle><date>2022-06-01</date><risdate>2022</risdate><volume>63</volume><issue>6</issue><spage>931</spage><epage>935</epage><pages>931-935</pages><issn>0161-5505</issn><eissn>1535-5667</eissn><abstract>Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are 4-repeat (4R) tauopathies with overlapping, but also morphologically distinct, tau immunoreactive lesions that vary in count by brain region. 18F-flortaucipir PET uptake has been reported to correlate with overall tau burden, and-in 1 CBD case-to have greater affinity to threads than tangles. We determined whether 18F-flortaucipir uptake is associated with histologic lesion type in 4R tauopathies. Methods: We performed semiquantitative regional lesion counts on pretangles/neurofibrillary tangles, threads, oligodendroglial coiled bodies, tufted astrocytes, and astrocytic plaques in 29 cases of autopsied 4R tauopathy (PSP, 16; CBD, 13). Regression models were used for statistical analyses. Results: 18F-flortaucipir uptake marginally correlated with threads in the precentral cortex (P = 0.04) and with astrocytic lesions in the red nucleus (P = 0.05). Conclusion: The findings do not support 18F-flortaucipir's having differential affinity to any 4R tau lesion type.</abstract><cop>New York</cop><pub>Society of Nuclear Medicine</pub><pmid>34556525</pmid><doi>10.2967/jnumed.121.262685</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of nuclear medicine (1978), 2022-06, Vol.63 (6), p.931-935 |
| issn | 0161-5505 1535-5667 |
| language | eng |
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| source | Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Affinity Astrocytes Autopsies Brief Communication Degeneration Lesions Neurodegeneration Neurodegenerative diseases Neurofibrillary tangles Paralysis Plaques Positron emission tomography Progressive supranuclear palsy Red nucleus Regression analysis Regression models Statistical analysis Tau protein |
| title | Relationship Between 18F-Flortaucipir Uptake and Histologic Lesion Types in 4-Repeat Tauopathies |
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