Loss of mitochondrial ATPase ATAD3A contributes to nonalcoholic fatty liver disease through accumulation of lipids and damaged mitochondria

Mitochondrial ATPase ATAD3A is essential for cholesterol transport, mitochondrial structure, and cell survival. However, the relationship between ATAD3A and nonalcoholic fatty liver disease (NAFLD) is largely unknown. In this study, we found that ATAD3A was upregulated in the progression of NAFLD in...

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Veröffentlicht in:	The Journal of biological chemistry 2022-06, Vol.298 (6), p.102008, Article 102008
Hauptverfasser:	Chen, Liting, Li, Yuchang, Sottas, Chantal, Lazaris, Anthoula, Petrillo, Stephanie K., Metrakos, Peter, Li, Lu, Ishida, Yuji, Saito, Takeshi, Garza, Samuel, Papadopoulos, Vassilios
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - metabolism Animals ATAD3A ATPases Associated with Diverse Cellular Activities - genetics ATPases Associated with Diverse Cellular Activities - metabolism autophagy Cell Line cholesterol fatty acid oxidation free fatty acid Hepatocytes - enzymology Humans Liver - enzymology Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mitochondria, Liver - pathology Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism mitochondrial respiration mitophagy NAFLD Non-alcoholic Fatty Liver Disease - enzymology Rats triglyceride Triglycerides - metabolism
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