Ficus exasperata Attenuates Acetaminophen-Induced Hepatic Damage via NF-κB Signaling Mechanism in Experimental Rat Model

Ficus exasperata has been used to treat ulcer, diabetes, fever, and a variety of stress-related disorders. Acetaminophen (APAP) overdose is the most common cause of drug-induced acute liver injury. In this study, we evaluated the hepatoprotective effect and antioxidant capacity of ethanolic extract...

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Veröffentlicht in:	BioMed research international 2022, Vol.2022 (1), p.6032511-6032511
Hauptverfasser:	Adetuyi, Babatunde Oluwafemi, Adebisi, Oluwaseun Abraham, Adetuyi, Oluwatosin Adefunke, Ogunlana, Olubanke Olujoke, Toloyai, Pere-Ebi, Egbuna, Chukwuebuka, Uche, Chukwuemelie Zedech, Khan, Johra, Adumanya, Obinna Chukwuemeka Uchenna, Patrick-Iwuanyanwu, Kingsley C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen Acetaminophen - pharmacology Analgesics Animals Antioxidants Antioxidants - pharmacology Antioxidants - therapeutic use Bilirubin Chemical and Drug Induced Liver Injury - drug therapy Cyclooxygenase-2 Diabetes mellitus Distilled water Drug dosages Ethanol Fever Ficus Ficus exasperata Flavonoids Glycosides Hepatotoxicity Hyperactivity IL-1β Interleukin 6 Laboratory animals Lipid peroxidation Lipids Liver Monocyte chemoattractant protein 1 NF-kappa B NF-κB protein Nitric oxide Overdose Oxidative stress Peroxidase Peroxidation Phenols Phytochemicals Proteins Rats Saponins Steroid hormones Steroids Toxicity Tumor necrosis factor-α Urination
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