Perivascular Fibrosis Is Mediated by a KLF10-IL-9 Signaling Axis in CD4+ T Cells

Perivascular fibrosis, characterized by increased amount of connective tissue around vessels, is a hallmark for vascular disease. Ang II (angiotensin II) contributes to vascular disease and end-organ damage via promoting T-cell activation. Despite recent data suggesting the role of T cells in the pr...

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Veröffentlicht in:	Circulation research 2022-05, Vol.130 (11), p.1662-1681
Hauptverfasser:	Zhuang, Rulin, Chen, Jingshu, Cheng, Henry S., Assa, Carmel, Jamaiyar, Anurag, Pandey, Arvind K., Pérez-Cremades, Daniel, Zhang, Bofang, Tzani, Aspasia, Khyrul Wara, Akm, Plutzky, Jorge, Barrera, Victor, Bhetariya, Preetida, Mitchell, Richard N., Liu, Zhongmin, Feinberg, Mark W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - pharmacology Animals CD4-Positive T-Lymphocytes - metabolism Early Growth Response Transcription Factors Fibrosis Humans Hypertension Interleukin-9 Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - metabolism Leukocytes, Mononuclear - metabolism Mice Mice, Inbred C57BL Mice, Knockout RNA
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