Molecular docking analysis of beta-caryophyllene with IRS-1, cSrc and Akt
Diabetes mellitus (DM) is a common metabolic illness defined by hyperglycemia caused by insufficient production or absent of pancreatic insulin, with or without concomitant insulin action impairment. Hence, novel problem-solving approaches for assessing early metabolic diseases, notably insulin resi...
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| Veröffentlicht in: | Bioinformation 2021-11, Vol.17 (11), p.916-920 |
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| creator | Mani, Vadivel Balraj, Manikandan Venktsan, Gayathri Soundrapandiyan, Jagatheesh Kasthuri, Revathi Danavel, Anandhi Babu, Shyamaladevi |
| description | Diabetes mellitus (DM) is a common metabolic illness defined by hyperglycemia caused by insufficient production or absent of pancreatic insulin, with or without concomitant insulin action impairment. Hence, novel problem-solving approaches for assessing early metabolic diseases, notably insulin resistance, are urgently needed. Screening of natural compounds for drug discovery to combat diabetes is common in modern medical research and development. Therefore, it is of interest to document the molecular docking analysis data of beta-Caryophyllene, a naturally occurring sequiterpene with the downstream insulin signaling molecules such as IRS-1, cSrc and Akt for the management of type-2 diabetes. The molecular docking analysis data of beta-caryophyllene with the insulin downstream signaling molecules such as IRS-1, cSrc and Akt reveals its ability and further studies are needed to elucidate its complete mechanism of action against type-2 diabetes. |
| doi_str_mv | 10.6026/97320630017916 |
| format | Article |
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Hence, novel problem-solving approaches for assessing early metabolic diseases, notably insulin resistance, are urgently needed. Screening of natural compounds for drug discovery to combat diabetes is common in modern medical research and development. Therefore, it is of interest to document the molecular docking analysis data of beta-Caryophyllene, a naturally occurring sequiterpene with the downstream insulin signaling molecules such as IRS-1, cSrc and Akt for the management of type-2 diabetes. 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The molecular docking analysis data of beta-caryophyllene with the insulin downstream signaling molecules such as IRS-1, cSrc and Akt reveals its ability and further studies are needed to elucidate its complete mechanism of action against type-2 diabetes.</description><subject>AKT protein</subject><subject>Caryophyllene</subject><subject>Data analysis</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Hyperglycemia</subject><subject>Insulin</subject><subject>Insulin receptor substrate 1</subject><subject>Insulin resistance</subject><subject>Medical research</subject><subject>Metabolic disorders</subject><subject>Metabolism</subject><subject>Molecular docking</subject><subject>Problem solving</subject><subject>R&D</subject><subject>Research & development</subject><subject>Signaling</subject><issn>0973-2063</issn><issn>0973-8894</issn><issn>0973-2063</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpdkc1LAzEQxYMotlavHmXBiwe35mM32VyEUvwoVASr55DNZttt001NdpX-96a0luopw8wvjzfzALhEsE8hpnecEQwpgRAxjugR6MLQiTet44O6A868n0OYIMbSU9AhKU1TjmAXjF6s0ao10kWFVYuqnkaylmbtKx_ZMsp1I2Ml3dquZmtjdK2j76qZRaO3SYxuIzVxKvBFNFg05-CklMbri93bAx-PD-_D53j8-jQaDsaxIknWxBnLEJVSo0wpwiXGOclpgTlWUuWhVkWKKEQ6ySVJkcxwyZgu8oQlOU00JqQH7re6qzZf6kLpunHSiJWrlsGnsLISfyd1NRNT-yU4SrKwdBC42Qk4-9lq34hl5ZU2Rtbatl5gykg4UHAb0Ot_6Ny2LtwnUCnnNDjEOFD9LaWc9d7pcm8GQbFJSfxNKXy4Olxhj__GQn4AIZCL4A</recordid><startdate>20211130</startdate><enddate>20211130</enddate><creator>Mani, Vadivel</creator><creator>Balraj, Manikandan</creator><creator>Venktsan, Gayathri</creator><creator>Soundrapandiyan, Jagatheesh</creator><creator>Kasthuri, Revathi</creator><creator>Danavel, Anandhi</creator><creator>Babu, Shyamaladevi</creator><general>Biomedical Informatics</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20211130</creationdate><title>Molecular docking analysis of beta-caryophyllene with IRS-1, cSrc and Akt</title><author>Mani, Vadivel ; 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| subjects | AKT protein Caryophyllene Data analysis Diabetes Diabetes mellitus Hyperglycemia Insulin Insulin receptor substrate 1 Insulin resistance Medical research Metabolic disorders Metabolism Molecular docking Problem solving R&D Research & development Signaling |
| title | Molecular docking analysis of beta-caryophyllene with IRS-1, cSrc and Akt |
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