Role of shear wave elastography in treatment follow-up of leprosy neuropathy
Purpose Grayscale ultrasonography when complemented with shear wave elastography helps in better evaluation of treatment response of leprosy neuropathy and in guiding appropriate management of the patient. There is limited literature regarding the use of shear wave elastography in ulnar nerve neurop...
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| Veröffentlicht in: | Journal of ultrasound 2022-06, Vol.25 (2), p.265-272 |
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| creator | Meghashyam, Kesha Prakash, Mahesh Narang, Tarun Sinha, Anindita Sandhu, M. S. |
| description | Purpose
Grayscale ultrasonography when complemented with shear wave elastography helps in better evaluation of treatment response of leprosy neuropathy and in guiding appropriate management of the patient. There is limited literature regarding the use of shear wave elastography in ulnar nerve neuropathy. Our purpose was to evaluate the role of shear wave elastography in assessing stiffness changes within the ulnar nerve during treatment of leprosy.
Methods
This was a prospective study which included 30 patients diagnosed with leprosy neuropathy. Recruited patients were followed up, during the course of treatment, i.e. for 1 year. Serial ultrasonography of these patients was done at 0, 3, 6 and 12 months interval.
Results
Significant (
P
|
| doi_str_mv | 10.1007/s40477-021-00583-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9148358</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2670965852</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-70ff9f59c52269ac479c8e34053b28a627f636d0f1bb5a3b4c65dee0c6ceec143</originalsourceid><addsrcrecordid>eNp9kV1PFDEUhhujEVj9A16YSbzhZrDfHzckhiCQbGJi9LrpdE93h3SnYzsD7L-3sIjghVdtep737TnnRegDwScEY_W5cMyVajElLcZCs_buFTokWslWGUZeP7sfoKNSritkmCJv0QFjRhht9CFafk8RmhSasgGXm1t3Aw1EV6a0zm7c7Jp-aKYMbtrCMDUhxZhu23m8V0QYcyq7ZoA5p9FNm9079Ca4WOD947lAP7-e_zi7bJffLq7OvixbzxWfWoVDMEEYLyiVxtVH4zUwjgXrqHaSqiCZXOFAuk441nEvxQoAe-kBPOFsgU73vuPcbWHla2vZRTvmfuvyzibX25eVod_YdbqxhnDN6qYW6PjRIKdfM5TJbvviIUY3QJqLpYJyJqnGqqKf_kGv05yHOp6lUmEjhRa0UnRP-bqSkiE8NUOwvQ_L7sOyNSz7EJa9q6KPz8d4kvxJpwJsD5RaGtaQ__79H9vflWyiAQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2670965852</pqid></control><display><type>article</type><title>Role of shear wave elastography in treatment follow-up of leprosy neuropathy</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Meghashyam, Kesha ; Prakash, Mahesh ; Narang, Tarun ; Sinha, Anindita ; Sandhu, M. S.</creator><creatorcontrib>Meghashyam, Kesha ; Prakash, Mahesh ; Narang, Tarun ; Sinha, Anindita ; Sandhu, M. S.</creatorcontrib><description>Purpose
Grayscale ultrasonography when complemented with shear wave elastography helps in better evaluation of treatment response of leprosy neuropathy and in guiding appropriate management of the patient. There is limited literature regarding the use of shear wave elastography in ulnar nerve neuropathy. Our purpose was to evaluate the role of shear wave elastography in assessing stiffness changes within the ulnar nerve during treatment of leprosy.
Methods
This was a prospective study which included 30 patients diagnosed with leprosy neuropathy. Recruited patients were followed up, during the course of treatment, i.e. for 1 year. Serial ultrasonography of these patients was done at 0, 3, 6 and 12 months interval.
Results
Significant (
P
< 0.05) decrease in elastography parameters was seen in transverse imaging plane between first and third, as well as first and fourth visits (mean stiffness and velocity pretreatment ~ 25.78 ± 18 kPa and 2.74 ± 0.98 m/s, mean stiffness and velocity post-treatment 15.67 ± 5.89 kPa and 2.24 ± 0.428 m/s). Although elastography parameters decreased during these visits in the long-axis imaging plane, they were not found to be statistically significant. However, gross morphology and cross-sectional area of the nerve did not change significantly across visits. Interestingly, elastography values were higher in patients with neuritis, though not statistically significant.
Conclusion
Shear wave elastography is a novel, upcoming modality in musculoskeletal imaging especially in the evaluation of peripheral neuropathy. It can act as an adjunct to grey-scale imaging, which can help in early diagnosis and in guiding treatment of leprosy neuropathy.</description><identifier>ISSN: 1876-7931</identifier><identifier>ISSN: 1971-3495</identifier><identifier>EISSN: 1876-7931</identifier><identifier>DOI: 10.1007/s40477-021-00583-x</identifier><identifier>PMID: 33959898</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Elasticity Imaging Techniques - methods ; Evaluation ; Follow-Up Studies ; Humans ; Leprosy ; Leprosy - complications ; Leprosy - diagnostic imaging ; Leprosy - therapy ; Mathematical morphology ; Medical imaging ; Medicine ; Medicine & Public Health ; Nerves ; Neuritis ; Parameters ; Peripheral Nervous System Diseases - diagnostic imaging ; Peripheral Nervous System Diseases - therapy ; Prospective Studies ; Shear ; Soft Tissue Infections ; Stiffness ; Ulnar Neuropathies ; Ultrasonic imaging ; Ultrasound</subject><ispartof>Journal of ultrasound, 2022-06, Vol.25 (2), p.265-272</ispartof><rights>Società Italiana di Ultrasonologia in Medicina e Biologia (SIUMB) 2021</rights><rights>2021. Società Italiana di Ultrasonologia in Medicina e Biologia (SIUMB).</rights><rights>Società Italiana di Ultrasonologia in Medicina e Biologia (SIUMB) 2021.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-70ff9f59c52269ac479c8e34053b28a627f636d0f1bb5a3b4c65dee0c6ceec143</citedby><cites>FETCH-LOGICAL-c474t-70ff9f59c52269ac479c8e34053b28a627f636d0f1bb5a3b4c65dee0c6ceec143</cites><orcidid>0000-0003-3843-1167</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148358/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148358/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,41467,42536,51297,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33959898$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meghashyam, Kesha</creatorcontrib><creatorcontrib>Prakash, Mahesh</creatorcontrib><creatorcontrib>Narang, Tarun</creatorcontrib><creatorcontrib>Sinha, Anindita</creatorcontrib><creatorcontrib>Sandhu, M. S.</creatorcontrib><title>Role of shear wave elastography in treatment follow-up of leprosy neuropathy</title><title>Journal of ultrasound</title><addtitle>J Ultrasound</addtitle><addtitle>J Ultrasound</addtitle><description>Purpose
Grayscale ultrasonography when complemented with shear wave elastography helps in better evaluation of treatment response of leprosy neuropathy and in guiding appropriate management of the patient. There is limited literature regarding the use of shear wave elastography in ulnar nerve neuropathy. Our purpose was to evaluate the role of shear wave elastography in assessing stiffness changes within the ulnar nerve during treatment of leprosy.
Methods
This was a prospective study which included 30 patients diagnosed with leprosy neuropathy. Recruited patients were followed up, during the course of treatment, i.e. for 1 year. Serial ultrasonography of these patients was done at 0, 3, 6 and 12 months interval.
Results
Significant (
P
< 0.05) decrease in elastography parameters was seen in transverse imaging plane between first and third, as well as first and fourth visits (mean stiffness and velocity pretreatment ~ 25.78 ± 18 kPa and 2.74 ± 0.98 m/s, mean stiffness and velocity post-treatment 15.67 ± 5.89 kPa and 2.24 ± 0.428 m/s). Although elastography parameters decreased during these visits in the long-axis imaging plane, they were not found to be statistically significant. However, gross morphology and cross-sectional area of the nerve did not change significantly across visits. Interestingly, elastography values were higher in patients with neuritis, though not statistically significant.
Conclusion
Shear wave elastography is a novel, upcoming modality in musculoskeletal imaging especially in the evaluation of peripheral neuropathy. It can act as an adjunct to grey-scale imaging, which can help in early diagnosis and in guiding treatment of leprosy neuropathy.</description><subject>Elasticity Imaging Techniques - methods</subject><subject>Evaluation</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Leprosy</subject><subject>Leprosy - complications</subject><subject>Leprosy - diagnostic imaging</subject><subject>Leprosy - therapy</subject><subject>Mathematical morphology</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nerves</subject><subject>Neuritis</subject><subject>Parameters</subject><subject>Peripheral Nervous System Diseases - diagnostic imaging</subject><subject>Peripheral Nervous System Diseases - therapy</subject><subject>Prospective Studies</subject><subject>Shear</subject><subject>Soft Tissue Infections</subject><subject>Stiffness</subject><subject>Ulnar Neuropathies</subject><subject>Ultrasonic imaging</subject><subject>Ultrasound</subject><issn>1876-7931</issn><issn>1971-3495</issn><issn>1876-7931</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV1PFDEUhhujEVj9A16YSbzhZrDfHzckhiCQbGJi9LrpdE93h3SnYzsD7L-3sIjghVdtep737TnnRegDwScEY_W5cMyVajElLcZCs_buFTokWslWGUZeP7sfoKNSritkmCJv0QFjRhht9CFafk8RmhSasgGXm1t3Aw1EV6a0zm7c7Jp-aKYMbtrCMDUhxZhu23m8V0QYcyq7ZoA5p9FNm9079Ca4WOD947lAP7-e_zi7bJffLq7OvixbzxWfWoVDMEEYLyiVxtVH4zUwjgXrqHaSqiCZXOFAuk441nEvxQoAe-kBPOFsgU73vuPcbWHla2vZRTvmfuvyzibX25eVod_YdbqxhnDN6qYW6PjRIKdfM5TJbvviIUY3QJqLpYJyJqnGqqKf_kGv05yHOp6lUmEjhRa0UnRP-bqSkiE8NUOwvQ_L7sOyNSz7EJa9q6KPz8d4kvxJpwJsD5RaGtaQ__79H9vflWyiAQ</recordid><startdate>20220601</startdate><enddate>20220601</enddate><creator>Meghashyam, Kesha</creator><creator>Prakash, Mahesh</creator><creator>Narang, Tarun</creator><creator>Sinha, Anindita</creator><creator>Sandhu, M. S.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3843-1167</orcidid></search><sort><creationdate>20220601</creationdate><title>Role of shear wave elastography in treatment follow-up of leprosy neuropathy</title><author>Meghashyam, Kesha ; Prakash, Mahesh ; Narang, Tarun ; Sinha, Anindita ; Sandhu, M. S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-70ff9f59c52269ac479c8e34053b28a627f636d0f1bb5a3b4c65dee0c6ceec143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Elasticity Imaging Techniques - methods</topic><topic>Evaluation</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Leprosy</topic><topic>Leprosy - complications</topic><topic>Leprosy - diagnostic imaging</topic><topic>Leprosy - therapy</topic><topic>Mathematical morphology</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nerves</topic><topic>Neuritis</topic><topic>Parameters</topic><topic>Peripheral Nervous System Diseases - diagnostic imaging</topic><topic>Peripheral Nervous System Diseases - therapy</topic><topic>Prospective Studies</topic><topic>Shear</topic><topic>Soft Tissue Infections</topic><topic>Stiffness</topic><topic>Ulnar Neuropathies</topic><topic>Ultrasonic imaging</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meghashyam, Kesha</creatorcontrib><creatorcontrib>Prakash, Mahesh</creatorcontrib><creatorcontrib>Narang, Tarun</creatorcontrib><creatorcontrib>Sinha, Anindita</creatorcontrib><creatorcontrib>Sandhu, M. S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of ultrasound</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meghashyam, Kesha</au><au>Prakash, Mahesh</au><au>Narang, Tarun</au><au>Sinha, Anindita</au><au>Sandhu, M. S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of shear wave elastography in treatment follow-up of leprosy neuropathy</atitle><jtitle>Journal of ultrasound</jtitle><stitle>J Ultrasound</stitle><addtitle>J Ultrasound</addtitle><date>2022-06-01</date><risdate>2022</risdate><volume>25</volume><issue>2</issue><spage>265</spage><epage>272</epage><pages>265-272</pages><issn>1876-7931</issn><issn>1971-3495</issn><eissn>1876-7931</eissn><abstract>Purpose
Grayscale ultrasonography when complemented with shear wave elastography helps in better evaluation of treatment response of leprosy neuropathy and in guiding appropriate management of the patient. There is limited literature regarding the use of shear wave elastography in ulnar nerve neuropathy. Our purpose was to evaluate the role of shear wave elastography in assessing stiffness changes within the ulnar nerve during treatment of leprosy.
Methods
This was a prospective study which included 30 patients diagnosed with leprosy neuropathy. Recruited patients were followed up, during the course of treatment, i.e. for 1 year. Serial ultrasonography of these patients was done at 0, 3, 6 and 12 months interval.
Results
Significant (
P
< 0.05) decrease in elastography parameters was seen in transverse imaging plane between first and third, as well as first and fourth visits (mean stiffness and velocity pretreatment ~ 25.78 ± 18 kPa and 2.74 ± 0.98 m/s, mean stiffness and velocity post-treatment 15.67 ± 5.89 kPa and 2.24 ± 0.428 m/s). Although elastography parameters decreased during these visits in the long-axis imaging plane, they were not found to be statistically significant. However, gross morphology and cross-sectional area of the nerve did not change significantly across visits. Interestingly, elastography values were higher in patients with neuritis, though not statistically significant.
Conclusion
Shear wave elastography is a novel, upcoming modality in musculoskeletal imaging especially in the evaluation of peripheral neuropathy. It can act as an adjunct to grey-scale imaging, which can help in early diagnosis and in guiding treatment of leprosy neuropathy.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>33959898</pmid><doi>10.1007/s40477-021-00583-x</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-3843-1167</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Elasticity Imaging Techniques - methods Evaluation Follow-Up Studies Humans Leprosy Leprosy - complications Leprosy - diagnostic imaging Leprosy - therapy Mathematical morphology Medical imaging Medicine Medicine & Public Health Nerves Neuritis Parameters Peripheral Nervous System Diseases - diagnostic imaging Peripheral Nervous System Diseases - therapy Prospective Studies Shear Soft Tissue Infections Stiffness Ulnar Neuropathies Ultrasonic imaging Ultrasound |
| title | Role of shear wave elastography in treatment follow-up of leprosy neuropathy |
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