Estimation of Functional Aerobic Capacity Using the Sit-to-Stand Test in Older Adults with Heart Failure with Preserved Ejection Fraction
Background: The 6-Min Walking Test (6MWT) has been proposed to assess functional aerobic capacity in patients with heart failure, but many older adults with heart failure cannot complete it. The adequacy of the 5-repetition Sit-To-Stand (5-STS), a simpler test than 6MWT, to assess the functional aer...
Gespeichert in:
| Veröffentlicht in: | Journal of clinical medicine 2022-05, Vol.11 (10), p.2692 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 10 |
| container_start_page | 2692 |
| container_title | Journal of clinical medicine |
| container_volume | 11 |
| creator | Fuentes-Abolafio, Iván José Escriche-Escuder, Adrian Bernal-López, María Rosa Gómez-Huelgas, Ricardo Ricci, Michele Trinidad-Fernández, Manuel Roldán-Jiménez, Cristina Arjona-Caballero, José María Cuesta-Vargas, Antonio Ignacio Pérez-Belmonte, Luis Miguel |
| description | Background: The 6-Min Walking Test (6MWT) has been proposed to assess functional aerobic capacity in patients with heart failure, but many older adults with heart failure cannot complete it. The adequacy of the 5-repetition Sit-To-Stand (5-STS), a simpler test than 6MWT, to assess the functional aerobic capacity in older adults with heart failure has not been evaluated. Objectives: This study aimed to assess the usefulness of 5-STS in estimating maximal oxygen uptake (VO2 peak) in older adults with heart failure with preserved ejection fraction (HFpEF). Methods: A cross-sectional study was carried out. Patients 70 years and older with HFpEF were included. A bivariant Pearson correlation and subsequent multivariate linear regression analysis were used to analyze the correlations between the 5-STS and the estimated VO2 peak. Results: Seventy-six patients (80.74 (5.89) years) were recruited. The 5-STS showed a moderate and inversely correlation with the estimated VO2 peak (r = −0.555, p < 0.001). The 5-STS explained 40.4% of the variance in the estimated VO2 peak, adjusted by age, sex, and BMI. When older adults were stratified by BMI, the 5-STS explained 70% and 31.4% of the variance in the estimated VO2 peak in older adults with normal weight and overweight/obesity, respectively. Conclusions: The 5-STS may be an easy tool to assess functional aerobic capacity in older adults with HFpEF, especially for those with normal weight. |
| doi_str_mv | 10.3390/jcm11102692 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9146258</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2671269179</sourcerecordid><originalsourceid>FETCH-LOGICAL-c409t-25d74c13d75234df0036132eac4773263a187f19f8f2becb5a5631766fd3226f3</originalsourceid><addsrcrecordid>eNpdkU9rGzEQxUVpaUKaU-9F0EuhbKs_u5L2UjDGbgqBFJKchSyNYpn1ypW0CfkI_dZV7DS4ncs8pB9Po3kIvafkC-c9-bqxW0opYaJnr9ApI1I2hCv--kifoPOcN6SWUi2j8i064Z1gStH-FP1e5BK2poQ44ujxchrtkzYDnkGKq2Dx3OyMDeUR3-Yw3uGyBnwdSlNic13M6PAN5ILDiK8GBwnP3DSUjB9CWeMLMKngpQnDlOBw9DNBhnQPDi82sH8JL5PZi3fojTdDhvPnfoZul4ub-UVzefX9x3x22diW9KVhnZOtpdzJjvHWeUK4oJyBsa2UnAluqJKe9l55tgK76kwnOJVCeMcZE56foW8H39202oKzMJZkBr1LdQ3pUUcT9L83Y1jru3ive9oK1qlq8OnZIMVfU_293oZsYRjMCHHKmglJax5U9hX9-B-6iVOq291ThPaUKVmpzwfKpphzAv8yDCX6KWV9lHKlPxzP_8L-zZT_AUpMo0E</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2670191287</pqid></control><display><type>article</type><title>Estimation of Functional Aerobic Capacity Using the Sit-to-Stand Test in Older Adults with Heart Failure with Preserved Ejection Fraction</title><source>PubMed Central Open Access</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Fuentes-Abolafio, Iván José ; Escriche-Escuder, Adrian ; Bernal-López, María Rosa ; Gómez-Huelgas, Ricardo ; Ricci, Michele ; Trinidad-Fernández, Manuel ; Roldán-Jiménez, Cristina ; Arjona-Caballero, José María ; Cuesta-Vargas, Antonio Ignacio ; Pérez-Belmonte, Luis Miguel</creator><creatorcontrib>Fuentes-Abolafio, Iván José ; Escriche-Escuder, Adrian ; Bernal-López, María Rosa ; Gómez-Huelgas, Ricardo ; Ricci, Michele ; Trinidad-Fernández, Manuel ; Roldán-Jiménez, Cristina ; Arjona-Caballero, José María ; Cuesta-Vargas, Antonio Ignacio ; Pérez-Belmonte, Luis Miguel</creatorcontrib><description>Background: The 6-Min Walking Test (6MWT) has been proposed to assess functional aerobic capacity in patients with heart failure, but many older adults with heart failure cannot complete it. The adequacy of the 5-repetition Sit-To-Stand (5-STS), a simpler test than 6MWT, to assess the functional aerobic capacity in older adults with heart failure has not been evaluated. Objectives: This study aimed to assess the usefulness of 5-STS in estimating maximal oxygen uptake (VO2 peak) in older adults with heart failure with preserved ejection fraction (HFpEF). Methods: A cross-sectional study was carried out. Patients 70 years and older with HFpEF were included. A bivariant Pearson correlation and subsequent multivariate linear regression analysis were used to analyze the correlations between the 5-STS and the estimated VO2 peak. Results: Seventy-six patients (80.74 (5.89) years) were recruited. The 5-STS showed a moderate and inversely correlation with the estimated VO2 peak (r = −0.555, p < 0.001). The 5-STS explained 40.4% of the variance in the estimated VO2 peak, adjusted by age, sex, and BMI. When older adults were stratified by BMI, the 5-STS explained 70% and 31.4% of the variance in the estimated VO2 peak in older adults with normal weight and overweight/obesity, respectively. Conclusions: The 5-STS may be an easy tool to assess functional aerobic capacity in older adults with HFpEF, especially for those with normal weight.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm11102692</identifier><identifier>PMID: 35628819</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Brief Report ; Chronic obstructive pulmonary disease ; Clinical medicine ; Dyspnea ; Ejection fraction ; Exercise ; Heart failure ; Life expectancy ; Maximum oxygen consumption ; Mortality ; Musculoskeletal system ; Older people ; Physical fitness ; Quality of life ; Statistical analysis</subject><ispartof>Journal of clinical medicine, 2022-05, Vol.11 (10), p.2692</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-25d74c13d75234df0036132eac4773263a187f19f8f2becb5a5631766fd3226f3</citedby><cites>FETCH-LOGICAL-c409t-25d74c13d75234df0036132eac4773263a187f19f8f2becb5a5631766fd3226f3</cites><orcidid>0000-0002-7355-9740 ; 0000-0002-8637-6222 ; 0000-0002-6246-4586 ; 0000-0002-8880-4315 ; 0000-0002-9909-3555 ; 0000-0001-7562-5986 ; 0000-0002-0238-0890 ; 0000-0003-4402-6483</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146258/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146258/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35628819$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fuentes-Abolafio, Iván José</creatorcontrib><creatorcontrib>Escriche-Escuder, Adrian</creatorcontrib><creatorcontrib>Bernal-López, María Rosa</creatorcontrib><creatorcontrib>Gómez-Huelgas, Ricardo</creatorcontrib><creatorcontrib>Ricci, Michele</creatorcontrib><creatorcontrib>Trinidad-Fernández, Manuel</creatorcontrib><creatorcontrib>Roldán-Jiménez, Cristina</creatorcontrib><creatorcontrib>Arjona-Caballero, José María</creatorcontrib><creatorcontrib>Cuesta-Vargas, Antonio Ignacio</creatorcontrib><creatorcontrib>Pérez-Belmonte, Luis Miguel</creatorcontrib><title>Estimation of Functional Aerobic Capacity Using the Sit-to-Stand Test in Older Adults with Heart Failure with Preserved Ejection Fraction</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>Background: The 6-Min Walking Test (6MWT) has been proposed to assess functional aerobic capacity in patients with heart failure, but many older adults with heart failure cannot complete it. The adequacy of the 5-repetition Sit-To-Stand (5-STS), a simpler test than 6MWT, to assess the functional aerobic capacity in older adults with heart failure has not been evaluated. Objectives: This study aimed to assess the usefulness of 5-STS in estimating maximal oxygen uptake (VO2 peak) in older adults with heart failure with preserved ejection fraction (HFpEF). Methods: A cross-sectional study was carried out. Patients 70 years and older with HFpEF were included. A bivariant Pearson correlation and subsequent multivariate linear regression analysis were used to analyze the correlations between the 5-STS and the estimated VO2 peak. Results: Seventy-six patients (80.74 (5.89) years) were recruited. The 5-STS showed a moderate and inversely correlation with the estimated VO2 peak (r = −0.555, p < 0.001). The 5-STS explained 40.4% of the variance in the estimated VO2 peak, adjusted by age, sex, and BMI. When older adults were stratified by BMI, the 5-STS explained 70% and 31.4% of the variance in the estimated VO2 peak in older adults with normal weight and overweight/obesity, respectively. Conclusions: The 5-STS may be an easy tool to assess functional aerobic capacity in older adults with HFpEF, especially for those with normal weight.</description><subject>Brief Report</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Clinical medicine</subject><subject>Dyspnea</subject><subject>Ejection fraction</subject><subject>Exercise</subject><subject>Heart failure</subject><subject>Life expectancy</subject><subject>Maximum oxygen consumption</subject><subject>Mortality</subject><subject>Musculoskeletal system</subject><subject>Older people</subject><subject>Physical fitness</subject><subject>Quality of life</subject><subject>Statistical analysis</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkU9rGzEQxUVpaUKaU-9F0EuhbKs_u5L2UjDGbgqBFJKchSyNYpn1ypW0CfkI_dZV7DS4ncs8pB9Po3kIvafkC-c9-bqxW0opYaJnr9ApI1I2hCv--kifoPOcN6SWUi2j8i064Z1gStH-FP1e5BK2poQ44ujxchrtkzYDnkGKq2Dx3OyMDeUR3-Yw3uGyBnwdSlNic13M6PAN5ILDiK8GBwnP3DSUjB9CWeMLMKngpQnDlOBw9DNBhnQPDi82sH8JL5PZi3fojTdDhvPnfoZul4ub-UVzefX9x3x22diW9KVhnZOtpdzJjvHWeUK4oJyBsa2UnAluqJKe9l55tgK76kwnOJVCeMcZE56foW8H39202oKzMJZkBr1LdQ3pUUcT9L83Y1jru3ive9oK1qlq8OnZIMVfU_293oZsYRjMCHHKmglJax5U9hX9-B-6iVOq291ThPaUKVmpzwfKpphzAv8yDCX6KWV9lHKlPxzP_8L-zZT_AUpMo0E</recordid><startdate>20220510</startdate><enddate>20220510</enddate><creator>Fuentes-Abolafio, Iván José</creator><creator>Escriche-Escuder, Adrian</creator><creator>Bernal-López, María Rosa</creator><creator>Gómez-Huelgas, Ricardo</creator><creator>Ricci, Michele</creator><creator>Trinidad-Fernández, Manuel</creator><creator>Roldán-Jiménez, Cristina</creator><creator>Arjona-Caballero, José María</creator><creator>Cuesta-Vargas, Antonio Ignacio</creator><creator>Pérez-Belmonte, Luis Miguel</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7355-9740</orcidid><orcidid>https://orcid.org/0000-0002-8637-6222</orcidid><orcidid>https://orcid.org/0000-0002-6246-4586</orcidid><orcidid>https://orcid.org/0000-0002-8880-4315</orcidid><orcidid>https://orcid.org/0000-0002-9909-3555</orcidid><orcidid>https://orcid.org/0000-0001-7562-5986</orcidid><orcidid>https://orcid.org/0000-0002-0238-0890</orcidid><orcidid>https://orcid.org/0000-0003-4402-6483</orcidid></search><sort><creationdate>20220510</creationdate><title>Estimation of Functional Aerobic Capacity Using the Sit-to-Stand Test in Older Adults with Heart Failure with Preserved Ejection Fraction</title><author>Fuentes-Abolafio, Iván José ; Escriche-Escuder, Adrian ; Bernal-López, María Rosa ; Gómez-Huelgas, Ricardo ; Ricci, Michele ; Trinidad-Fernández, Manuel ; Roldán-Jiménez, Cristina ; Arjona-Caballero, José María ; Cuesta-Vargas, Antonio Ignacio ; Pérez-Belmonte, Luis Miguel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-25d74c13d75234df0036132eac4773263a187f19f8f2becb5a5631766fd3226f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Brief Report</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Clinical medicine</topic><topic>Dyspnea</topic><topic>Ejection fraction</topic><topic>Exercise</topic><topic>Heart failure</topic><topic>Life expectancy</topic><topic>Maximum oxygen consumption</topic><topic>Mortality</topic><topic>Musculoskeletal system</topic><topic>Older people</topic><topic>Physical fitness</topic><topic>Quality of life</topic><topic>Statistical analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fuentes-Abolafio, Iván José</creatorcontrib><creatorcontrib>Escriche-Escuder, Adrian</creatorcontrib><creatorcontrib>Bernal-López, María Rosa</creatorcontrib><creatorcontrib>Gómez-Huelgas, Ricardo</creatorcontrib><creatorcontrib>Ricci, Michele</creatorcontrib><creatorcontrib>Trinidad-Fernández, Manuel</creatorcontrib><creatorcontrib>Roldán-Jiménez, Cristina</creatorcontrib><creatorcontrib>Arjona-Caballero, José María</creatorcontrib><creatorcontrib>Cuesta-Vargas, Antonio Ignacio</creatorcontrib><creatorcontrib>Pérez-Belmonte, Luis Miguel</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fuentes-Abolafio, Iván José</au><au>Escriche-Escuder, Adrian</au><au>Bernal-López, María Rosa</au><au>Gómez-Huelgas, Ricardo</au><au>Ricci, Michele</au><au>Trinidad-Fernández, Manuel</au><au>Roldán-Jiménez, Cristina</au><au>Arjona-Caballero, José María</au><au>Cuesta-Vargas, Antonio Ignacio</au><au>Pérez-Belmonte, Luis Miguel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Estimation of Functional Aerobic Capacity Using the Sit-to-Stand Test in Older Adults with Heart Failure with Preserved Ejection Fraction</atitle><jtitle>Journal of clinical medicine</jtitle><addtitle>J Clin Med</addtitle><date>2022-05-10</date><risdate>2022</risdate><volume>11</volume><issue>10</issue><spage>2692</spage><pages>2692-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>Background: The 6-Min Walking Test (6MWT) has been proposed to assess functional aerobic capacity in patients with heart failure, but many older adults with heart failure cannot complete it. The adequacy of the 5-repetition Sit-To-Stand (5-STS), a simpler test than 6MWT, to assess the functional aerobic capacity in older adults with heart failure has not been evaluated. Objectives: This study aimed to assess the usefulness of 5-STS in estimating maximal oxygen uptake (VO2 peak) in older adults with heart failure with preserved ejection fraction (HFpEF). Methods: A cross-sectional study was carried out. Patients 70 years and older with HFpEF were included. A bivariant Pearson correlation and subsequent multivariate linear regression analysis were used to analyze the correlations between the 5-STS and the estimated VO2 peak. Results: Seventy-six patients (80.74 (5.89) years) were recruited. The 5-STS showed a moderate and inversely correlation with the estimated VO2 peak (r = −0.555, p < 0.001). The 5-STS explained 40.4% of the variance in the estimated VO2 peak, adjusted by age, sex, and BMI. When older adults were stratified by BMI, the 5-STS explained 70% and 31.4% of the variance in the estimated VO2 peak in older adults with normal weight and overweight/obesity, respectively. Conclusions: The 5-STS may be an easy tool to assess functional aerobic capacity in older adults with HFpEF, especially for those with normal weight.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>35628819</pmid><doi>10.3390/jcm11102692</doi><orcidid>https://orcid.org/0000-0002-7355-9740</orcidid><orcidid>https://orcid.org/0000-0002-8637-6222</orcidid><orcidid>https://orcid.org/0000-0002-6246-4586</orcidid><orcidid>https://orcid.org/0000-0002-8880-4315</orcidid><orcidid>https://orcid.org/0000-0002-9909-3555</orcidid><orcidid>https://orcid.org/0000-0001-7562-5986</orcidid><orcidid>https://orcid.org/0000-0002-0238-0890</orcidid><orcidid>https://orcid.org/0000-0003-4402-6483</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2077-0383 |
| ispartof | Journal of clinical medicine, 2022-05, Vol.11 (10), p.2692 |
| issn | 2077-0383 2077-0383 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9146258 |
| source | PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Brief Report Chronic obstructive pulmonary disease Clinical medicine Dyspnea Ejection fraction Exercise Heart failure Life expectancy Maximum oxygen consumption Mortality Musculoskeletal system Older people Physical fitness Quality of life Statistical analysis |
| title | Estimation of Functional Aerobic Capacity Using the Sit-to-Stand Test in Older Adults with Heart Failure with Preserved Ejection Fraction |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T12%3A15%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Estimation%20of%20Functional%20Aerobic%20Capacity%20Using%20the%20Sit-to-Stand%20Test%20in%20Older%20Adults%20with%20Heart%20Failure%20with%20Preserved%20Ejection%20Fraction&rft.jtitle=Journal%20of%20clinical%20medicine&rft.au=Fuentes-Abolafio,%20Iv%C3%A1n%20Jos%C3%A9&rft.date=2022-05-10&rft.volume=11&rft.issue=10&rft.spage=2692&rft.pages=2692-&rft.issn=2077-0383&rft.eissn=2077-0383&rft_id=info:doi/10.3390/jcm11102692&rft_dat=%3Cproquest_pubme%3E2671269179%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2670191287&rft_id=info:pmid/35628819&rfr_iscdi=true |