Activation of Focal Adhesion Kinase Restores Simulated Microgravity-Induced Inhibition of Osteoblast Differentiation via Wnt/Β-Catenin Pathway

Simulated microgravity (SMG) inhibits osteoblast differentiation (OBD) and induces bone loss via the inhibition of the Wnt/β-catenin pathway. However, the mechanism by which SMG alters the Wnt/β-catenin pathway is unknown. We previously demonstrated that SMG altered the focal adhesion kinase (FAK)-r...

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Veröffentlicht in:	International journal of molecular sciences 2022-05, Vol.23 (10), p.5593
Hauptverfasser:	Fan, Cuihong, Wu, Zhaojia, Cooper, David M L, Magnus, Adam, Harrison, Kim, Eames, B Frank, Chibbar, Rajni, Groot, Gary, Huang, Junqiong, Genth, Harald, Zhang, Jun, Tan, Xing, Deng, Yulin, Xiang, Jim
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Apoptosis Astronauts Biomedical materials Bone density Bone loss Bone morphogenetic protein 2 Cancellous bone Cell division Cell proliferation Collagen Computed tomography Cytoskeleton Cytotoxic necrotizing factor 1 Cytotoxicity Differentiation Extracellular signal-regulated kinase Focal adhesion kinase Gene expression Kinases Localization Metastases Microscopy Mineralization Osteoblastogenesis Osteoblasts Osteoporosis Physiology Proteins Therapeutic targets Transcription factors Tumors Wnt protein β-Catenin
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