Premortem Skin Biopsy Assessing Microthrombi, Interferon Type I Antiviral and Regulatory Proteins, and Complement Deposition Correlates with Coronavirus Disease 2019 Clinical Stage

Apart from autopsy, tissue correlates of coronavirus disease 2019 (COVID-19) clinical stage are lacking. In the current study, cutaneous punch biopsy specimens of 15 individuals with severe/critical COVID-19 and six with mild/moderate COVID-19 were examined. Evidence for arterial and venous microthr...

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Veröffentlicht in:	The American journal of pathology 2022-09, Vol.192 (9), p.1282-1294
Hauptverfasser:	Laurence, Jeffrey, Nuovo, Gerard, Racine-Brzostek, Sabrina E., Seshadri, Madhav, Elhadad, Sonia, Crowson, A. Neil, Mulvey, J. Justin, Harp, Joanna, Ahamed, Jasimuddin, Magro, Cynthia
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury Antiviral Agents Biopsy Complement Membrane Attack Complex COVID-19 Humans Interferon Type I Mannose-Binding Protein-Associated Serine Proteases Regular Respiratory Distress Syndrome Spike Glycoprotein, Coronavirus Thrombosis
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