A Comparative Genome-Wide Transcriptome Analysis of Glucocorticoid Responder and Non-Responder Primary Human Trabecular Meshwork Cells

To investigate genes and pathways involved in differential glucocorticoid (GC) responsiveness in human trabecular meshwork (HTM) cells using RNA sequencing. Using paired human donor eyes, human organ-cultured anterior segment (HOCAS) was established in one eye to characterize GC responsiveness based...

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Veröffentlicht in:	Genes 2022-05, Vol.13 (5), p.882
Hauptverfasser:	Kathirvel, Kandasamy, Haribalaganesh, Ravinarayanan, Krishnadas, Ramasamy, Muthukkaruppan, Veerappan, Willoughby, Colin E, Bharanidharan, Devarajan, Senthilkumari, Srinivasan
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Care and treatment Cell adhesion Cell culture Corticosteroids Cytochrome P450 Dexamethasone Diagnosis Dosage and administration Drug metabolism Ethanol Experiments Eye Gene expression Gene Expression Profiling Genetic aspects Genomes Glaucoma Glucocorticoids Glucocorticoids - metabolism Glucocorticoids - pharmacology Humans Hypertension Intraocular Pressure MAP kinase Pressure transducers Ribonucleic acid RNA RNA sequencing Signal transduction Steroids Therapeutic targets Trabecular Meshwork - metabolism Transcriptome - genetics Transcriptomes Wnt protein
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