Is Gross Extrathyroidal Extension to Strap Muscles (T3b) Only a Risk Factor for Recurrence in Papillary Thyroid Carcinoma? A Propensity Score Matching Study
The presence of extrathyroidal extension (ETE) is associated with locoregional recurrence and distant metastases in papillary thyroid carcinoma (PTC). This study was designed to compare the recurrence risk between minimal ETE (mETE) and gross ETE (gETE) in patients with PTC using propensity score ma...
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| Veröffentlicht in: | Cancers 2022-05, Vol.14 (10), p.2370 |
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| description | The presence of extrathyroidal extension (ETE) is associated with locoregional recurrence and distant metastases in papillary thyroid carcinoma (PTC). This study was designed to compare the recurrence risk between minimal ETE (mETE) and gross ETE (gETE) in patients with PTC using propensity score matching. In this study, 4452 patients with PTC who underwent thyroid surgery in a single center were retrospectively analyzed, and clinicopathological characteristics were compared according to the ETE status. Disease-free survival (DFS) and recurrence risk were compared between mETE and gETE after propensity score matching. The mean follow-up duration was 122.7 ± 22.5 months. In multivariate analysis, both mETE and gETE were not associated with recurrence risk before propensity score matching (
= 0.154 and
= 0.072, respectively). After propensity score matching, no significant difference in recurrence rates was observed between the two groups (
= 0.668). DFS of the gETE group did not significantly differ from that of the mETE group (log-rank
= 0.531). This study revealed that both mETE and gETE are not independent risk factors for the risk of recurrence in PTC. Our findings suggest that gETE invading strap muscles only might not be associated with worse oncological outcomes in PTC. |
| doi_str_mv | 10.3390/cancers14102370 |
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= 0.154 and
= 0.072, respectively). After propensity score matching, no significant difference in recurrence rates was observed between the two groups (
= 0.668). DFS of the gETE group did not significantly differ from that of the mETE group (log-rank
= 0.531). This study revealed that both mETE and gETE are not independent risk factors for the risk of recurrence in PTC. Our findings suggest that gETE invading strap muscles only might not be associated with worse oncological outcomes in PTC.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers14102370</identifier><identifier>PMID: 35625974</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Ablation ; Bias ; Biopsy ; Medical prognosis ; Metastases ; Multivariate analysis ; Muscles ; Papillary thyroid carcinoma ; Pathology ; Patients ; Regression analysis ; Risk factors ; Survival ; Survival analysis ; Thyroid ; Thyroid cancer ; Thyroidectomy ; Tomography</subject><ispartof>Cancers, 2022-05, Vol.14 (10), p.2370</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3360-3ce94ebf129db73504abbb99e50ba64dee18ad607865d9e35e32c77258cb2af63</citedby><cites>FETCH-LOGICAL-c3360-3ce94ebf129db73504abbb99e50ba64dee18ad607865d9e35e32c77258cb2af63</cites><orcidid>0000-0002-9982-7838 ; 0000-0001-6403-6035</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139627/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139627/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35625974$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Yongseon</creatorcontrib><creatorcontrib>Kim, Yong-Seok</creatorcontrib><creatorcontrib>Bae, Ja Seong</creatorcontrib><creatorcontrib>Kim, Jeong Soo</creatorcontrib><creatorcontrib>Kim, Kwangsoon</creatorcontrib><title>Is Gross Extrathyroidal Extension to Strap Muscles (T3b) Only a Risk Factor for Recurrence in Papillary Thyroid Carcinoma? A Propensity Score Matching Study</title><title>Cancers</title><addtitle>Cancers (Basel)</addtitle><description>The presence of extrathyroidal extension (ETE) is associated with locoregional recurrence and distant metastases in papillary thyroid carcinoma (PTC). This study was designed to compare the recurrence risk between minimal ETE (mETE) and gross ETE (gETE) in patients with PTC using propensity score matching. In this study, 4452 patients with PTC who underwent thyroid surgery in a single center were retrospectively analyzed, and clinicopathological characteristics were compared according to the ETE status. Disease-free survival (DFS) and recurrence risk were compared between mETE and gETE after propensity score matching. The mean follow-up duration was 122.7 ± 22.5 months. In multivariate analysis, both mETE and gETE were not associated with recurrence risk before propensity score matching (
= 0.154 and
= 0.072, respectively). After propensity score matching, no significant difference in recurrence rates was observed between the two groups (
= 0.668). DFS of the gETE group did not significantly differ from that of the mETE group (log-rank
= 0.531). This study revealed that both mETE and gETE are not independent risk factors for the risk of recurrence in PTC. Our findings suggest that gETE invading strap muscles only might not be associated with worse oncological outcomes in PTC.</description><subject>Ablation</subject><subject>Bias</subject><subject>Biopsy</subject><subject>Medical prognosis</subject><subject>Metastases</subject><subject>Multivariate analysis</subject><subject>Muscles</subject><subject>Papillary thyroid carcinoma</subject><subject>Pathology</subject><subject>Patients</subject><subject>Regression analysis</subject><subject>Risk factors</subject><subject>Survival</subject><subject>Survival analysis</subject><subject>Thyroid</subject><subject>Thyroid cancer</subject><subject>Thyroidectomy</subject><subject>Tomography</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkU9P3DAQxa2qVUGUc2_VSL3Qwxb_Sez1pRVaAUUCgWB7jhxnwppm7dROqua79MPW0VJEsWTZ1vz8Zp4eIe8Z_SyEpsfWeIsxsYJRLhR9RfY5VXwhpS5eP7vvkcOUHmheQjAl1VuyJ0rJS62KffLnIsF5DCnB6e8hmmEzxeAa081P9MkFD0OAu1zq4WpMtsMER2tRf4Jr301g4NalH3Bm7BAitHnfoh1jxDwZOA83pnddZ-IE650yrEy0zoet-QoncBNDP3cZJrizISJcmcFunL_PHcdmekfetKZLePh4HpDvZ6fr1bfF5fX5xerkcmGFkHQhLOoC65Zx3dRKlLQwdV1rjSWtjSwaRLY0jaRqKctGoyhRcKsUL5e25qaV4oB82en2Y73FxqLPfruqj26bR6-CcdX_Fe821X34VWkmtOQqCxw9CsTwc8Q0VFuXLGbnHsOYKi4VyxhnIqMfX6APYYw-25spSrUu2Sx4vKPsnE3E9mkYRqs5_OpF-PnHh-cenvh_UYu_CMOuGA</recordid><startdate>20220511</startdate><enddate>20220511</enddate><creator>Kim, Yongseon</creator><creator>Kim, Yong-Seok</creator><creator>Bae, Ja Seong</creator><creator>Kim, Jeong Soo</creator><creator>Kim, Kwangsoon</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9982-7838</orcidid><orcidid>https://orcid.org/0000-0001-6403-6035</orcidid></search><sort><creationdate>20220511</creationdate><title>Is Gross Extrathyroidal Extension to Strap Muscles (T3b) Only a Risk Factor for Recurrence in Papillary Thyroid Carcinoma? A Propensity Score Matching Study</title><author>Kim, Yongseon ; Kim, Yong-Seok ; Bae, Ja Seong ; Kim, Jeong Soo ; Kim, Kwangsoon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3360-3ce94ebf129db73504abbb99e50ba64dee18ad607865d9e35e32c77258cb2af63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Ablation</topic><topic>Bias</topic><topic>Biopsy</topic><topic>Medical prognosis</topic><topic>Metastases</topic><topic>Multivariate analysis</topic><topic>Muscles</topic><topic>Papillary thyroid carcinoma</topic><topic>Pathology</topic><topic>Patients</topic><topic>Regression analysis</topic><topic>Risk factors</topic><topic>Survival</topic><topic>Survival analysis</topic><topic>Thyroid</topic><topic>Thyroid cancer</topic><topic>Thyroidectomy</topic><topic>Tomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Yongseon</creatorcontrib><creatorcontrib>Kim, Yong-Seok</creatorcontrib><creatorcontrib>Bae, Ja Seong</creatorcontrib><creatorcontrib>Kim, Jeong Soo</creatorcontrib><creatorcontrib>Kim, Kwangsoon</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Yongseon</au><au>Kim, Yong-Seok</au><au>Bae, Ja Seong</au><au>Kim, Jeong Soo</au><au>Kim, Kwangsoon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is Gross Extrathyroidal Extension to Strap Muscles (T3b) Only a Risk Factor for Recurrence in Papillary Thyroid Carcinoma? A Propensity Score Matching Study</atitle><jtitle>Cancers</jtitle><addtitle>Cancers (Basel)</addtitle><date>2022-05-11</date><risdate>2022</risdate><volume>14</volume><issue>10</issue><spage>2370</spage><pages>2370-</pages><issn>2072-6694</issn><eissn>2072-6694</eissn><abstract>The presence of extrathyroidal extension (ETE) is associated with locoregional recurrence and distant metastases in papillary thyroid carcinoma (PTC). This study was designed to compare the recurrence risk between minimal ETE (mETE) and gross ETE (gETE) in patients with PTC using propensity score matching. In this study, 4452 patients with PTC who underwent thyroid surgery in a single center were retrospectively analyzed, and clinicopathological characteristics were compared according to the ETE status. Disease-free survival (DFS) and recurrence risk were compared between mETE and gETE after propensity score matching. The mean follow-up duration was 122.7 ± 22.5 months. In multivariate analysis, both mETE and gETE were not associated with recurrence risk before propensity score matching (
= 0.154 and
= 0.072, respectively). After propensity score matching, no significant difference in recurrence rates was observed between the two groups (
= 0.668). DFS of the gETE group did not significantly differ from that of the mETE group (log-rank
= 0.531). This study revealed that both mETE and gETE are not independent risk factors for the risk of recurrence in PTC. Our findings suggest that gETE invading strap muscles only might not be associated with worse oncological outcomes in PTC.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>35625974</pmid><doi>10.3390/cancers14102370</doi><orcidid>https://orcid.org/0000-0002-9982-7838</orcidid><orcidid>https://orcid.org/0000-0001-6403-6035</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Ablation Bias Biopsy Medical prognosis Metastases Multivariate analysis Muscles Papillary thyroid carcinoma Pathology Patients Regression analysis Risk factors Survival Survival analysis Thyroid Thyroid cancer Thyroidectomy Tomography |
| title | Is Gross Extrathyroidal Extension to Strap Muscles (T3b) Only a Risk Factor for Recurrence in Papillary Thyroid Carcinoma? A Propensity Score Matching Study |
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