Correlation of the Histological ICRS II Score and the 3D MOCART Score for the Analysis of Aged Osteochondral Regenerates in a Large Animal Model
Objective Reliable outcome measures are essential to predict the success of cartilage repair techniques. Histology is probably the gold standard, but magnetic resonance imaging (MRI) has the potential to decrease the need for invasive histological biopsies. The 3D magnetic resonance observation of c...
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| Veröffentlicht in: | Cartilage 2022-01, Vol.13 (1), p.19476035211072254-19476035211072254 |
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| creator | Schagemann, J.C. Galle, L. Gille, J. Frydrychowicz, A. Welsch, G. Salzmann, G. Paech, A. Mittelstaedt, H. |
| description | Objective
Reliable outcome measures are essential to predict the success of cartilage repair techniques. Histology is probably the gold standard, but magnetic resonance imaging (MRI) has the potential to decrease the need for invasive histological biopsies. The 3D magnetic resonance observation of cartilage repair tissue (MOCART) score is a reliable yet elaborate tool. Moreover, literature is controversial concerning the correlation of histology and MRI.
Design
To test the applicability of the International Cartilage Regeneration and Joint Preservation Society (ICRS) II and MOCART 3D score for the evaluation of aged osteochondral regenerates in a large animal model, and to identify correlating histological and MRI parameters. Osteochondral defects in medial femoral condyles of n = 12 adult sheep were reconstructed with biodegradable bilayer implants. About 19.5 months postoperation, n = 10 joints were analyzed with MRI (3D MOCART score). Histological samples were analyzed using the ICRS II score; both pre- and post-training. The intraclass correlation coefficient, the inter-rater reliability, and the 95% confidence interval were calculated. Matching histological and MRI parameters were tested for correlation.
Results
We found a statistically significant correlation of all histological parameters. MRI parameters reflecting “overall” assessments had very strong inter-rater correlations. Statistically significant strong correlations were found for the MRI parameters defect filling, cartilage interface, bone interface, and surface. For defect overall (MRI) and overall assessment (ICRS II), we found a significant yet mild correlation.
Conclusions
The ICRS II and the 3D MOCART score are applicable to aged osteochondral regenerates. Prior training on the scoring systems is essential. Select MRI and histological parameters correlate; however, the only statistically significant correlation was found for overall assessment. |
| doi_str_mv | 10.1177/19476035211072254 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9137325</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_19476035211072254</sage_id><sourcerecordid>2630920645</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-ab72b51802cb4e5c1a5f32e8c463eab944fb1ad44012de659a6b7ee7e9322313</originalsourceid><addsrcrecordid>eNp9kc1qGzEUhUVpSNIkD9BN0bIbp_rXzKZgpj8xOBgc74VGc2esMJZSaRzIW_SROxO7pqXQlcS953w66CD0npJbSrX-REuhFeGSUUo0Y1K8QZfTbKaI4G9Pdy4v0LucHwlRqizkObrgkmpVlOIS_axiStDbwceAY4uHLeA7n4fYx8472-NFtX7AiwV-cDEBtqF5lfAv-H5Vzdeb47yN6XU-D7Z_yT5PqHkHDV7lAaLbxtCkEbaGDgIkO0DGPmCLlzZ1k8vvxu19bKC_Rmet7TPcHM8rtPn2dVPdzZar74tqvpw5wYthZmvNakkLwlwtQDpqZcsZFE4oDrYuhWhrahshCGUNKFlaVWsADSVnjFN-hT4fsE_7egeNgzCMAc1TGpOkFxOtN39vgt-aLj6bknLNmRwBH4-AFH_sIQ9m57ODvrcB4j4bpjgpGVFiktKD1KWYc4L29AwlZirS_FPk6PnwZ76T43dzo-D2IMi2A_MY92n8-vwf4i-WNKYn</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2630920645</pqid></control><display><type>article</type><title>Correlation of the Histological ICRS II Score and the 3D MOCART Score for the Analysis of Aged Osteochondral Regenerates in a Large Animal Model</title><source>MEDLINE</source><source>Sage Journals GOLD Open Access 2024</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Schagemann, J.C. ; Galle, L. ; Gille, J. ; Frydrychowicz, A. ; Welsch, G. ; Salzmann, G. ; Paech, A. ; Mittelstaedt, H.</creator><creatorcontrib>Schagemann, J.C. ; Galle, L. ; Gille, J. ; Frydrychowicz, A. ; Welsch, G. ; Salzmann, G. ; Paech, A. ; Mittelstaedt, H.</creatorcontrib><description>Objective
Reliable outcome measures are essential to predict the success of cartilage repair techniques. Histology is probably the gold standard, but magnetic resonance imaging (MRI) has the potential to decrease the need for invasive histological biopsies. The 3D magnetic resonance observation of cartilage repair tissue (MOCART) score is a reliable yet elaborate tool. Moreover, literature is controversial concerning the correlation of histology and MRI.
Design
To test the applicability of the International Cartilage Regeneration and Joint Preservation Society (ICRS) II and MOCART 3D score for the evaluation of aged osteochondral regenerates in a large animal model, and to identify correlating histological and MRI parameters. Osteochondral defects in medial femoral condyles of n = 12 adult sheep were reconstructed with biodegradable bilayer implants. About 19.5 months postoperation, n = 10 joints were analyzed with MRI (3D MOCART score). Histological samples were analyzed using the ICRS II score; both pre- and post-training. The intraclass correlation coefficient, the inter-rater reliability, and the 95% confidence interval were calculated. Matching histological and MRI parameters were tested for correlation.
Results
We found a statistically significant correlation of all histological parameters. MRI parameters reflecting “overall” assessments had very strong inter-rater correlations. Statistically significant strong correlations were found for the MRI parameters defect filling, cartilage interface, bone interface, and surface. For defect overall (MRI) and overall assessment (ICRS II), we found a significant yet mild correlation.
Conclusions
The ICRS II and the 3D MOCART score are applicable to aged osteochondral regenerates. Prior training on the scoring systems is essential. Select MRI and histological parameters correlate; however, the only statistically significant correlation was found for overall assessment.</description><identifier>ISSN: 1947-6035</identifier><identifier>EISSN: 1947-6043</identifier><identifier>DOI: 10.1177/19476035211072254</identifier><identifier>PMID: 35176894</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Animals ; Cartilage, Articular - pathology ; Disease Models, Animal ; Intra-Articular Fractures ; Knee Joint - pathology ; Magnetic Resonance Imaging - methods ; Original ; Reproducibility of Results ; Sheep</subject><ispartof>Cartilage, 2022-01, Vol.13 (1), p.19476035211072254-19476035211072254</ispartof><rights>The Author(s) 2022</rights><rights>The Author(s) 2022 2022 SAGE Publications Ltd unless otherwise noted. Manuscript content on this site is licensed under Creative Commons Licenses</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-ab72b51802cb4e5c1a5f32e8c463eab944fb1ad44012de659a6b7ee7e9322313</citedby><cites>FETCH-LOGICAL-c438t-ab72b51802cb4e5c1a5f32e8c463eab944fb1ad44012de659a6b7ee7e9322313</cites><orcidid>0000-0002-5122-5897 ; 0000-0002-8199-5390</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9137325/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9137325/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,21945,27830,27901,27902,44921,45309,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35176894$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schagemann, J.C.</creatorcontrib><creatorcontrib>Galle, L.</creatorcontrib><creatorcontrib>Gille, J.</creatorcontrib><creatorcontrib>Frydrychowicz, A.</creatorcontrib><creatorcontrib>Welsch, G.</creatorcontrib><creatorcontrib>Salzmann, G.</creatorcontrib><creatorcontrib>Paech, A.</creatorcontrib><creatorcontrib>Mittelstaedt, H.</creatorcontrib><title>Correlation of the Histological ICRS II Score and the 3D MOCART Score for the Analysis of Aged Osteochondral Regenerates in a Large Animal Model</title><title>Cartilage</title><addtitle>Cartilage</addtitle><description>Objective
Reliable outcome measures are essential to predict the success of cartilage repair techniques. Histology is probably the gold standard, but magnetic resonance imaging (MRI) has the potential to decrease the need for invasive histological biopsies. The 3D magnetic resonance observation of cartilage repair tissue (MOCART) score is a reliable yet elaborate tool. Moreover, literature is controversial concerning the correlation of histology and MRI.
Design
To test the applicability of the International Cartilage Regeneration and Joint Preservation Society (ICRS) II and MOCART 3D score for the evaluation of aged osteochondral regenerates in a large animal model, and to identify correlating histological and MRI parameters. Osteochondral defects in medial femoral condyles of n = 12 adult sheep were reconstructed with biodegradable bilayer implants. About 19.5 months postoperation, n = 10 joints were analyzed with MRI (3D MOCART score). Histological samples were analyzed using the ICRS II score; both pre- and post-training. The intraclass correlation coefficient, the inter-rater reliability, and the 95% confidence interval were calculated. Matching histological and MRI parameters were tested for correlation.
Results
We found a statistically significant correlation of all histological parameters. MRI parameters reflecting “overall” assessments had very strong inter-rater correlations. Statistically significant strong correlations were found for the MRI parameters defect filling, cartilage interface, bone interface, and surface. For defect overall (MRI) and overall assessment (ICRS II), we found a significant yet mild correlation.
Conclusions
The ICRS II and the 3D MOCART score are applicable to aged osteochondral regenerates. Prior training on the scoring systems is essential. Select MRI and histological parameters correlate; however, the only statistically significant correlation was found for overall assessment.</description><subject>Animals</subject><subject>Cartilage, Articular - pathology</subject><subject>Disease Models, Animal</subject><subject>Intra-Articular Fractures</subject><subject>Knee Joint - pathology</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Original</subject><subject>Reproducibility of Results</subject><subject>Sheep</subject><issn>1947-6035</issn><issn>1947-6043</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>EIF</sourceid><recordid>eNp9kc1qGzEUhUVpSNIkD9BN0bIbp_rXzKZgpj8xOBgc74VGc2esMJZSaRzIW_SROxO7pqXQlcS953w66CD0npJbSrX-REuhFeGSUUo0Y1K8QZfTbKaI4G9Pdy4v0LucHwlRqizkObrgkmpVlOIS_axiStDbwceAY4uHLeA7n4fYx8472-NFtX7AiwV-cDEBtqF5lfAv-H5Vzdeb47yN6XU-D7Z_yT5PqHkHDV7lAaLbxtCkEbaGDgIkO0DGPmCLlzZ1k8vvxu19bKC_Rmet7TPcHM8rtPn2dVPdzZar74tqvpw5wYthZmvNakkLwlwtQDpqZcsZFE4oDrYuhWhrahshCGUNKFlaVWsADSVnjFN-hT4fsE_7egeNgzCMAc1TGpOkFxOtN39vgt-aLj6bknLNmRwBH4-AFH_sIQ9m57ODvrcB4j4bpjgpGVFiktKD1KWYc4L29AwlZirS_FPk6PnwZ76T43dzo-D2IMi2A_MY92n8-vwf4i-WNKYn</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>Schagemann, J.C.</creator><creator>Galle, L.</creator><creator>Gille, J.</creator><creator>Frydrychowicz, A.</creator><creator>Welsch, G.</creator><creator>Salzmann, G.</creator><creator>Paech, A.</creator><creator>Mittelstaedt, H.</creator><general>SAGE Publications</general><scope>AFRWT</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5122-5897</orcidid><orcidid>https://orcid.org/0000-0002-8199-5390</orcidid></search><sort><creationdate>20220101</creationdate><title>Correlation of the Histological ICRS II Score and the 3D MOCART Score for the Analysis of Aged Osteochondral Regenerates in a Large Animal Model</title><author>Schagemann, J.C. ; Galle, L. ; Gille, J. ; Frydrychowicz, A. ; Welsch, G. ; Salzmann, G. ; Paech, A. ; Mittelstaedt, H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-ab72b51802cb4e5c1a5f32e8c463eab944fb1ad44012de659a6b7ee7e9322313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animals</topic><topic>Cartilage, Articular - pathology</topic><topic>Disease Models, Animal</topic><topic>Intra-Articular Fractures</topic><topic>Knee Joint - pathology</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Original</topic><topic>Reproducibility of Results</topic><topic>Sheep</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schagemann, J.C.</creatorcontrib><creatorcontrib>Galle, L.</creatorcontrib><creatorcontrib>Gille, J.</creatorcontrib><creatorcontrib>Frydrychowicz, A.</creatorcontrib><creatorcontrib>Welsch, G.</creatorcontrib><creatorcontrib>Salzmann, G.</creatorcontrib><creatorcontrib>Paech, A.</creatorcontrib><creatorcontrib>Mittelstaedt, H.</creatorcontrib><collection>Sage Journals GOLD Open Access 2024</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cartilage</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schagemann, J.C.</au><au>Galle, L.</au><au>Gille, J.</au><au>Frydrychowicz, A.</au><au>Welsch, G.</au><au>Salzmann, G.</au><au>Paech, A.</au><au>Mittelstaedt, H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation of the Histological ICRS II Score and the 3D MOCART Score for the Analysis of Aged Osteochondral Regenerates in a Large Animal Model</atitle><jtitle>Cartilage</jtitle><addtitle>Cartilage</addtitle><date>2022-01-01</date><risdate>2022</risdate><volume>13</volume><issue>1</issue><spage>19476035211072254</spage><epage>19476035211072254</epage><pages>19476035211072254-19476035211072254</pages><issn>1947-6035</issn><eissn>1947-6043</eissn><abstract>Objective
Reliable outcome measures are essential to predict the success of cartilage repair techniques. Histology is probably the gold standard, but magnetic resonance imaging (MRI) has the potential to decrease the need for invasive histological biopsies. The 3D magnetic resonance observation of cartilage repair tissue (MOCART) score is a reliable yet elaborate tool. Moreover, literature is controversial concerning the correlation of histology and MRI.
Design
To test the applicability of the International Cartilage Regeneration and Joint Preservation Society (ICRS) II and MOCART 3D score for the evaluation of aged osteochondral regenerates in a large animal model, and to identify correlating histological and MRI parameters. Osteochondral defects in medial femoral condyles of n = 12 adult sheep were reconstructed with biodegradable bilayer implants. About 19.5 months postoperation, n = 10 joints were analyzed with MRI (3D MOCART score). Histological samples were analyzed using the ICRS II score; both pre- and post-training. The intraclass correlation coefficient, the inter-rater reliability, and the 95% confidence interval were calculated. Matching histological and MRI parameters were tested for correlation.
Results
We found a statistically significant correlation of all histological parameters. MRI parameters reflecting “overall” assessments had very strong inter-rater correlations. Statistically significant strong correlations were found for the MRI parameters defect filling, cartilage interface, bone interface, and surface. For defect overall (MRI) and overall assessment (ICRS II), we found a significant yet mild correlation.
Conclusions
The ICRS II and the 3D MOCART score are applicable to aged osteochondral regenerates. Prior training on the scoring systems is essential. Select MRI and histological parameters correlate; however, the only statistically significant correlation was found for overall assessment.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>35176894</pmid><doi>10.1177/19476035211072254</doi><orcidid>https://orcid.org/0000-0002-5122-5897</orcidid><orcidid>https://orcid.org/0000-0002-8199-5390</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1947-6035 |
| ispartof | Cartilage, 2022-01, Vol.13 (1), p.19476035211072254-19476035211072254 |
| issn | 1947-6035 1947-6043 |
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| source | MEDLINE; Sage Journals GOLD Open Access 2024; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Cartilage, Articular - pathology Disease Models, Animal Intra-Articular Fractures Knee Joint - pathology Magnetic Resonance Imaging - methods Original Reproducibility of Results Sheep |
| title | Correlation of the Histological ICRS II Score and the 3D MOCART Score for the Analysis of Aged Osteochondral Regenerates in a Large Animal Model |
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