The effects of two gold-N-heterocyclic carbene (NHC) complexes in ovarian cancer cells: a redox proteomic study

Purpose Ovarian cancer is the fifth leading cause of cancer-related deaths in women. Standard treatment consists of tumor debulking surgery followed by platinum and paclitaxel chemotherapy; yet, despite the initial response, about 70–75% of patients develop resistance to chemotherapy. Gold compounds...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2022-06, Vol.89 (6), p.809-823
Hauptverfasser:	Massai, Lara, Messori, Luigi, Carpentieri, Andrea, Amoresano, Angela, Melchiorre, Chiara, Fiaschi, Tania, Modesti, Alessandra, Gamberi, Tania, Magherini, Francesca
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic drugs Antitumor agents Apoptosis Cancer Research Carbenes Carbohydrate metabolism Carbohydrates Carcinoma, Ovarian Epithelial Cell adhesion Cell Line, Tumor Cell migration cell movement Chemotherapy Coordination Complexes - chemistry Coordination Complexes - pharmacology cysteine Cytoskeleton Cytotoxicity drug therapy Electron transport chain Female Glyceraldehyde-3-phosphate dehydrogenase Gold Gold - chemistry Gold Compounds Humans Mass spectrometry Mass spectroscopy mechanism of action Medicine Medicine & Public Health Methane - analogs & derivatives Mitochondria Mode of action Oncology Original Original Article Ovarian cancer ovarian neoplasms Ovarian Neoplasms - drug therapy Oxidation Oxidation-Reduction Paclitaxel Pharmacology/Toxicology Platinum Proteins Proteomics Redox properties Selenocysteine surgery Toxicity Tumors
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