Single-cell transcriptomics reveals age-resistant maintenance of cell identities, stem cell compartments and differentiation trajectories in long-lived naked mole-rats skin

Naked mole-rats (NMR) are subterranean rodents characterized by an unusual longevity coupled with an unexplained resistance to aging. In the present study, we performed extensive analysis and single-cell RNA-sequencing comparing young and older animals. At variance with other species, NMR exhibited...

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Veröffentlicht in:	Aging (Albany, NY.) NY.), 2022-05, Vol.14 (9), p.3728-3756
Hauptverfasser:	Savina, Aleksandra, Jaffredo, Thierry, Saldmann, Frederic, Faulkes, Chris G, Moguelet, Philippe, Leroy, Christine, Marmol, Delphine Del, Codogno, Patrice, Foucher, Lucy, Zalc, Antoine, Viltard, Mélanie, Friedlander, Gérard, Aractingi, Selim, Fontaine, Romain H
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - genetics Animals Life Sciences Longevity - genetics Mice Mole Rats - genetics Research Paper Stem Cells Transcriptome
Online-Zugang:	Volltext
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