Environmental robustness of the global yeast genetic interaction network

Phenotypes associated with genetic variants can be altered by interactions with other genetic variants (GxG), with the environment (GxE), or both (GxGxE). Yeast genetic interactions have been mapped on a global scale, but the environmental influence on the plasticity of genetic networks has not been...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2021-05, Vol.372 (6542)
Hauptverfasser:	Costanzo, Michael, Hou, Jing, Messier, Vincent, Nelson, Justin, Rahman, Mahfuzur, VanderSluis, Benjamin, Wang, Wen, Pons, Carles, Ross, Catherine, Ušaj, Matej, San Luis, Bryan-Joseph, Shuteriqi, Emira, Koch, Elizabeth N, Aloy, Patrick, Myers, Chad L, Boone, Charles, Andrews, Brenda
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Bioactive compounds Carbon sources Environment Environmental conditions Environmental impact Environmental Influences Environmental testing Gene mapping Gene Regulatory Networks Gene-Environment Interaction Genes Genetic diversity Genetic Fitness Genetic variance Genetics Genotoxicity Genotype & phenotype Genotypes Life Sciences Mutants Mutation Networks Perturbation Phenotypes Plastic properties Plasticity Rewiring Robustness Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins - genetics Temperature-sensitive mutant Yeast Yeasts Zebrafish
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