Final results of the DisCoVeRy trial of remdesivir for patients admitted to hospital with COVID-19
Eligible participants were adults (aged ≥18 years) who were admitted to hospital with a positive PCR test for SARS-CoV-2 (
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| Veröffentlicht in: | The Lancet infectious diseases 2022-06, Vol.22 (6), p.764-765 |
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| creator | Ader, Florence Hites, Maya Peiffer-Smadja, Nathan Burdet, Charles Aboab, Jérôme Altdorfer, Antoine Andreu, Pascal Bani-Sadr, Firouzé Belhadi, Drifa Benezit, François Berna, Marc Blot, Mathieu Botelho-Nevers, Elisabeth Bouadma, Lila Bouiller, Kevin Bounes-Vardon, Fanny Bouscambert-Duchamp, Maude Boutoille, David Boyer, Alexandre Cabié, André Canet, Emmanuel Cazanave, Charles Chabartier, Cyrille Chirouze, Catherine Clere-Jehl, Raphaël Costagliola, Dominique Couffin-Cadièrgues, Sandrine Courjon, Johan Crockett, Flora Dechanet, Aline Delbove, Agathe Dellamonica, Jean Diallo, Alpha Esperou, Hélène Fartoukh, Murielle Ferreira Ribeiro, Joao-Miguel Ferry, Tristan Ficko, Cécile Figueiredo, Samy Fraipont, Vincent Gagneux-Brunon, Amandine Gaymard, Alexandre Geri, Guillaume Goehringer, François Gousseff, Marie Gruson, Didier Guedj, Jérémie Hansmann, Yves Hinschberger, Olivier Hites, Maya Jaureguiberry, Stéphane Kerneis, Solen Kimmoun, Antoine Lacombe, Karine Lamprecht, Bernd Lanoix, Jean-Philippe Lê, Minh-Patrick Le Moing, Vincent Le Tulzo, Yves Leroy, Sylvie Lescure, François-Xavier Lessire, Henry Leveau, Benjamin Loubet, Paul Mentré, France Mira, Jean-Paul Monnet, Xavier Mootien, Joy Mourvilliers, Bruno Murris-Espin, Marlène Navellou, Jean-Christophe Noret, Marion Paiva, José-Artur Pialoux, Gilles Piriou, Vincent Piroth, Lionel Poissy, Julien Pourcher, Valérie Quenot, Jean-Pierre Raffi, François Reignier, Jean Riu-Poulenc, Béatrice Robert, Céline Roger, Pierre-Alexandre Roger, Claire Roncon-Albuquerque, Roberto Saidani, Nadia Saillard, Juliette Senneville, Eric Tacquard, Charles Terzi, Nicolas Textoris, Julien Thiery, Guillaume Timsit, Jean-François Tubiana, Sarah Valour, Florent Vardon-Bounes, Fanny Velou, Priyanka Verschelden, Gil Yazdanpanah, Yazdan |
| description | Eligible participants were adults (aged ≥18 years) who were admitted to hospital with a positive PCR test for SARS-CoV-2 ( |
| doi_str_mv | 10.1016/S1473-3099(22)00295-X |
| format | Article |
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Hites, Maya ; Peiffer-Smadja, Nathan ; Burdet, Charles ; Aboab, Jérôme ; Altdorfer, Antoine ; Andreu, Pascal ; Bani-Sadr, Firouzé ; Belhadi, Drifa ; Benezit, François ; Berna, Marc ; Blot, Mathieu ; Botelho-Nevers, Elisabeth ; Bouadma, Lila ; Bouiller, Kevin ; Bounes-Vardon, Fanny ; Bouscambert-Duchamp, Maude ; Boutoille, David ; Boyer, Alexandre ; Cabié, André ; Canet, Emmanuel ; Cazanave, Charles ; Chabartier, Cyrille ; Chirouze, Catherine ; Clere-Jehl, Raphaël ; Costagliola, Dominique ; Couffin-Cadièrgues, Sandrine ; Courjon, Johan ; Crockett, Flora ; Dechanet, Aline ; Delbove, Agathe ; Dellamonica, Jean ; Diallo, Alpha ; Esperou, Hélène ; Fartoukh, Murielle ; Ferreira Ribeiro, Joao-Miguel ; Ferry, Tristan ; Ficko, Cécile ; Figueiredo, Samy ; Fraipont, Vincent ; Gagneux-Brunon, Amandine ; Gaymard, Alexandre ; Geri, Guillaume ; Goehringer, François ; Gousseff, Marie ; Gruson, Didier ; Guedj, Jérémie ; Hansmann, Yves ; Hinschberger, Olivier ; Hites, Maya ; Jaureguiberry, Stéphane ; Kerneis, Solen ; Kimmoun, Antoine ; Lacombe, Karine ; Lamprecht, Bernd ; Lanoix, Jean-Philippe ; Lê, Minh-Patrick ; Le Moing, Vincent ; Le Tulzo, Yves ; Leroy, Sylvie ; Lescure, François-Xavier ; Lessire, Henry ; Leveau, Benjamin ; Loubet, Paul ; Mentré, France ; Mira, Jean-Paul ; Monnet, Xavier ; Mootien, Joy ; Mourvilliers, Bruno ; Murris-Espin, Marlène ; Navellou, Jean-Christophe ; Noret, Marion ; Paiva, José-Artur ; Pialoux, Gilles ; Piriou, Vincent ; Piroth, Lionel ; Poissy, Julien ; Pourcher, Valérie ; Quenot, Jean-Pierre ; Raffi, François ; Reignier, Jean ; Riu-Poulenc, Béatrice ; Robert, Céline ; Roger, Pierre-Alexandre ; Roger, Claire ; Roncon-Albuquerque, Roberto ; Saidani, Nadia ; Saillard, Juliette ; Senneville, Eric ; Tacquard, Charles ; Terzi, Nicolas ; Textoris, Julien ; Thiery, Guillaume ; Timsit, Jean-François ; Tubiana, Sarah ; Valour, Florent ; Vardon-Bounes, Fanny ; Velou, Priyanka ; Verschelden, Gil ; Yazdanpanah, Yazdan</creator><creatorcontrib>Ader, Florence ; Hites, Maya ; Peiffer-Smadja, Nathan ; Burdet, Charles ; Aboab, Jérôme ; Altdorfer, Antoine ; Andreu, Pascal ; Bani-Sadr, Firouzé ; Belhadi, Drifa ; Benezit, François ; Berna, Marc ; Blot, Mathieu ; Botelho-Nevers, Elisabeth ; Bouadma, Lila ; Bouiller, Kevin ; Bounes-Vardon, Fanny ; Bouscambert-Duchamp, Maude ; Boutoille, David ; Boyer, Alexandre ; Cabié, André ; Canet, Emmanuel ; Cazanave, Charles ; Chabartier, Cyrille ; Chirouze, Catherine ; Clere-Jehl, Raphaël ; Costagliola, Dominique ; Couffin-Cadièrgues, Sandrine ; Courjon, Johan ; Crockett, Flora ; Dechanet, Aline ; Delbove, Agathe ; Dellamonica, Jean ; Diallo, Alpha ; Esperou, Hélène ; Fartoukh, Murielle ; Ferreira Ribeiro, Joao-Miguel ; Ferry, Tristan ; Ficko, Cécile ; Figueiredo, Samy ; Fraipont, Vincent ; Gagneux-Brunon, Amandine ; Gaymard, Alexandre ; Geri, Guillaume ; Goehringer, François ; Gousseff, Marie ; Gruson, Didier ; Guedj, Jérémie ; Hansmann, Yves ; Hinschberger, Olivier ; Hites, Maya ; Jaureguiberry, Stéphane ; Kerneis, Solen ; Kimmoun, Antoine ; Lacombe, Karine ; Lamprecht, Bernd ; Lanoix, Jean-Philippe ; Lê, Minh-Patrick ; Le Moing, Vincent ; Le Tulzo, Yves ; Leroy, Sylvie ; Lescure, François-Xavier ; Lessire, Henry ; Leveau, Benjamin ; Loubet, Paul ; Mentré, France ; Mira, Jean-Paul ; Monnet, Xavier ; Mootien, Joy ; Mourvilliers, Bruno ; Murris-Espin, Marlène ; Navellou, Jean-Christophe ; Noret, Marion ; Paiva, José-Artur ; Pialoux, Gilles ; Piriou, Vincent ; Piroth, Lionel ; Poissy, Julien ; Pourcher, Valérie ; Quenot, Jean-Pierre ; Raffi, François ; Reignier, Jean ; Riu-Poulenc, Béatrice ; Robert, Céline ; Roger, Pierre-Alexandre ; Roger, Claire ; Roncon-Albuquerque, Roberto ; Saidani, Nadia ; Saillard, Juliette ; Senneville, Eric ; Tacquard, Charles ; Terzi, Nicolas ; Textoris, Julien ; Thiery, Guillaume ; Timsit, Jean-François ; Tubiana, Sarah ; Valour, Florent ; Vardon-Bounes, Fanny ; Velou, Priyanka ; Verschelden, Gil ; Yazdanpanah, Yazdan ; DisCoVeRy Study Group</creatorcontrib><description>Eligible participants were adults (aged ≥18 years) who were admitted to hospital with a positive PCR test for SARS-CoV-2 (<72 h before randomisation) and also had pulmonary rales or crackles with a peripheral oxygen saturation of 94% or less or required supplemental oxygen. Similar to findings from preliminary analyses, participants from the remdesivir group who were not on mechanical ventilation or ECMO when they were randomly assigned to a treatment group (n=692) had a significantly longer time to the composite endpoint of new mechanical ventilation, ECMO, or death in the 29 days following randomisation than did the control group (cumulative incidence in the remdesivir group was 58 [17%] of 343 participants vs 88 [25%] of 349 in the control group; adjusted hazard ratio [HR] 0·63 [95% CI 0·45–0·88]; p=0·010). In non-prespecified analyses, this effect was significant in participants with severe disease when they were randomly assigned to a treatment group (cumulative incidence in the remdesivir group 25 [29%] of 87 vs 47 [50%] of 94 in the control group; unadjusted HR 0·49 [95% CI 0·30–0·80]; p=0·0040) but not in those with moderate disease (33 (13%) of 256 vs 41 (16%) of 255; 0·79 [0·50–1·25]; p=0·31).</description><identifier>ISSN: 1473-3099</identifier><identifier>EISSN: 1474-4457</identifier><identifier>DOI: 10.1016/S1473-3099(22)00295-X</identifier><identifier>PMID: 35643099</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Adenosine Monophosphate - analogs & derivatives ; Adenosine Monophosphate - therapeutic use ; Alanine - analogs & derivatives ; Alanine - therapeutic use ; Clinical Trials as Topic ; Coronaviruses ; Correspondence ; COVID-19 ; COVID-19 - drug therapy ; Hospitalization ; Hospitals ; Humans ; Infectious diseases ; Life Sciences ; Mechanical ventilation ; Mortality ; Oxygen ; Oxygen content ; Randomization ; Severe acute respiratory syndrome coronavirus 2 ; Ventilation</subject><ispartof>The Lancet infectious diseases, 2022-06, Vol.22 (6), p.764-765</ispartof><rights>2022 Elsevier Ltd</rights><rights>2022. 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results of the DisCoVeRy trial of remdesivir for patients admitted to hospital with COVID-19</title><author>Ader, Florence ; Hites, Maya ; Peiffer-Smadja, Nathan ; Burdet, Charles ; Aboab, Jérôme ; Altdorfer, Antoine ; Andreu, Pascal ; Bani-Sadr, Firouzé ; Belhadi, Drifa ; Benezit, François ; Berna, Marc ; Blot, Mathieu ; Botelho-Nevers, Elisabeth ; Bouadma, Lila ; Bouiller, Kevin ; Bounes-Vardon, Fanny ; Bouscambert-Duchamp, Maude ; Boutoille, David ; Boyer, Alexandre ; Cabié, André ; Canet, Emmanuel ; Cazanave, Charles ; Chabartier, Cyrille ; Chirouze, Catherine ; Clere-Jehl, Raphaël ; Costagliola, Dominique ; Couffin-Cadièrgues, Sandrine ; Courjon, Johan ; Crockett, Flora ; Dechanet, Aline ; Delbove, Agathe ; Dellamonica, Jean ; Diallo, Alpha ; Esperou, Hélène ; Fartoukh, Murielle ; Ferreira Ribeiro, Joao-Miguel ; Ferry, Tristan ; Ficko, Cécile ; Figueiredo, Samy ; Fraipont, Vincent ; Gagneux-Brunon, Amandine ; Gaymard, Alexandre ; Geri, Guillaume ; Goehringer, François ; Gousseff, Marie ; Gruson, Didier ; Guedj, Jérémie ; Hansmann, Yves ; Hinschberger, Olivier ; Hites, Maya ; Jaureguiberry, Stéphane ; Kerneis, Solen ; Kimmoun, Antoine ; Lacombe, Karine ; Lamprecht, Bernd ; Lanoix, Jean-Philippe ; Lê, Minh-Patrick ; Le Moing, Vincent ; Le Tulzo, Yves ; Leroy, Sylvie ; Lescure, François-Xavier ; Lessire, Henry ; Leveau, Benjamin ; Loubet, Paul ; Mentré, France ; Mira, Jean-Paul ; Monnet, Xavier ; Mootien, Joy ; Mourvilliers, Bruno ; Murris-Espin, Marlène ; Navellou, Jean-Christophe ; Noret, Marion ; Paiva, José-Artur ; Pialoux, Gilles ; Piriou, Vincent ; Piroth, Lionel ; Poissy, Julien ; Pourcher, Valérie ; Quenot, Jean-Pierre ; Raffi, François ; Reignier, Jean ; Riu-Poulenc, Béatrice ; Robert, Céline ; Roger, Pierre-Alexandre ; Roger, Claire ; Roncon-Albuquerque, Roberto ; Saidani, Nadia ; Saillard, Juliette ; Senneville, Eric ; Tacquard, Charles ; Terzi, Nicolas ; Textoris, Julien ; Thiery, Guillaume ; Timsit, Jean-François ; Tubiana, Sarah ; Valour, Florent ; Vardon-Bounes, Fanny ; Velou, Priyanka ; Verschelden, Gil ; Yazdanpanah, Yazdan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c529t-e58620e2e2361951c5e8984f31a3cd4cf1c9dae1603f3cba2f1b579bba20ae1c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adenosine Monophosphate - analogs & derivatives</topic><topic>Adenosine Monophosphate - therapeutic use</topic><topic>Alanine - analogs & derivatives</topic><topic>Alanine - therapeutic use</topic><topic>Clinical Trials as Topic</topic><topic>Coronaviruses</topic><topic>Correspondence</topic><topic>COVID-19</topic><topic>COVID-19 - drug therapy</topic><topic>Hospitalization</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Life Sciences</topic><topic>Mechanical ventilation</topic><topic>Mortality</topic><topic>Oxygen</topic><topic>Oxygen 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Dis</addtitle><date>2022-06-01</date><risdate>2022</risdate><volume>22</volume><issue>6</issue><spage>764</spage><epage>765</epage><pages>764-765</pages><issn>1473-3099</issn><eissn>1474-4457</eissn><abstract>Eligible participants were adults (aged ≥18 years) who were admitted to hospital with a positive PCR test for SARS-CoV-2 (<72 h before randomisation) and also had pulmonary rales or crackles with a peripheral oxygen saturation of 94% or less or required supplemental oxygen. Similar to findings from preliminary analyses, participants from the remdesivir group who were not on mechanical ventilation or ECMO when they were randomly assigned to a treatment group (n=692) had a significantly longer time to the composite endpoint of new mechanical ventilation, ECMO, or death in the 29 days following randomisation than did the control group (cumulative incidence in the remdesivir group was 58 [17%] of 343 participants vs 88 [25%] of 349 in the control group; adjusted hazard ratio [HR] 0·63 [95% CI 0·45–0·88]; p=0·010). 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| fulltext | fulltext |
| identifier | ISSN: 1473-3099 |
| ispartof | The Lancet infectious diseases, 2022-06, Vol.22 (6), p.764-765 |
| issn | 1473-3099 1474-4457 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9132543 |
| source | MEDLINE; Elsevier ScienceDirect Journals; ProQuest Central UK/Ireland |
| subjects | Adenosine Monophosphate - analogs & derivatives Adenosine Monophosphate - therapeutic use Alanine - analogs & derivatives Alanine - therapeutic use Clinical Trials as Topic Coronaviruses Correspondence COVID-19 COVID-19 - drug therapy Hospitalization Hospitals Humans Infectious diseases Life Sciences Mechanical ventilation Mortality Oxygen Oxygen content Randomization Severe acute respiratory syndrome coronavirus 2 Ventilation |
| title | Final results of the DisCoVeRy trial of remdesivir for patients admitted to hospital with COVID-19 |
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