Exploiting protease activation for therapy

•Novel discovery approaches are based on proteolytic activation.•Antibody therapies targeting proteolytic activation.•Activatable pro-forms of antibodies or effector proteins. Proteases have crucial roles in homeostasis and disease; and protease inhibitors and recombinant proteases in enzyme replace...

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Veröffentlicht in:	Drug discovery today 2022-06, Vol.27 (6), p.1743-1754
Hauptverfasser:	Bleuez, Chloe, Koch, Wolfgang F., Urbach, Carole, Hollfelder, Florian, Jermutus, Lutz
Format:	Artikel
Sprache:	eng
Schlagworte:	Activatable therapeutics Antibody engineering Cytokine Peptide Hydrolases Post-Screen (Grey) Protease Protease Inhibitors - pharmacology Protease Inhibitors - therapeutic use Proteolysis Proteolytic activation Therapeutic antibodies Zymogen
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