Identification of hereditary breast and ovarian cancer germline variants in Granada (Spain): NGS perspective

The aim of this study was to assess the prevalence of germline variants in cancer-predisposing genes by either targeted ( BRCA1/2 ) or multigene NGS panel in a high-risk Hereditary Breast and Ovarian Cancer (HBOC) cohort. Samples from 824 Caucasian probands were retrospectively collected and the imp...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular genetics and genomics : MGG 2022-05, Vol.297 (3), p.859-871
Hauptverfasser:	Molina-Zayas, María, Garrido-Navas, Carmen, García-Puche, Jose Luis, Barwell, Julian, Pedrinaci, Susana, Atienza, Margarita Martínez, García-Linares, Susana, de Haro-Muñoz, Tomás, Lorente, Jose Antonio, Serrano, M. Jose, Poyatos-Andújar, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Genetics and Genomics Biochemistry Biomedical and Life Sciences BRCA1 protein BRCA2 protein Breast cancer Diagnosis Epidemiology ErbB-2 protein Genetic diversity Genetic screening Human Genetics Life Sciences Mastectomy Microbial Genetics and Genomics MSH6 protein Oophorectomy Original Original Article Ovarian cancer Ovariectomy p53 Protein Pathogenicity Patients Plant Genetics and Genomics Risk groups
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!