Postdischarge outcomes of COVID-19 patients from South Asia: a prospective study
Coronavirus disease 2019 (COVID-19) may cause clinical manifestations that last for weeks or months after hospital discharge. The manifestations are heterogeneous and vary in their frequency. Their multisystem nature requires a holistic approach to management. There are sparse data from the South As...
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| Veröffentlicht in: | Transactions of the Royal Society of Tropical Medicine and Hygiene 2022-12, Vol.116 (12), p.1129-1137 |
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| creator | Abeysuriya, Visula Seneviratne, Suranjith L De Silva, Arjuna P Mowjood, Riaz Mowjood, Shazli de Silva, Thushara de Mel, Primesh de Mel, Chandima Wijesinha, R S Fernando, Amitha de Mel, Sanjay Chandrasena, Lal |
| description | Coronavirus disease 2019 (COVID-19) may cause clinical manifestations that last for weeks or months after hospital discharge. The manifestations are heterogeneous and vary in their frequency. Their multisystem nature requires a holistic approach to management. There are sparse data from the South Asian region on the outcomes of hospital-discharged COVID-19 patients. We assessed the posthospital discharge outcomes of a cohort of Sri Lankan COVID-19 patients and explored the factors that influenced these outcomes.
Data were prospectively collected from patients who were discharged following an admission to the Nawaloka Hospital, Sri Lanka with COVID-19 from March to June 2021. At discharge, their demographic, clinical and laboratory findings were recorded. The patients were categorised as having mild, moderate and severe COVID-19, based on the Sri Lanka Ministry of Health COVID-19 guidelines. Following discharge, information on health status, complications and outcomes was collected through clinic visits and preplanned telephone interviews. A validated (in Sri Lanka) version of the Short Form 36 health survey questionnaire (SF-36) was used to assess multi-item dimensions health status of the patients at 1, 2 and 3 mo postdischarge.
We collected data on 203 patients (male, n=111 [54.7%]). The level of vaccination was significantly associated with disease severity (p |
| doi_str_mv | 10.1093/trstmh/trac039 |
| format | Article |
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Data were prospectively collected from patients who were discharged following an admission to the Nawaloka Hospital, Sri Lanka with COVID-19 from March to June 2021. At discharge, their demographic, clinical and laboratory findings were recorded. The patients were categorised as having mild, moderate and severe COVID-19, based on the Sri Lanka Ministry of Health COVID-19 guidelines. Following discharge, information on health status, complications and outcomes was collected through clinic visits and preplanned telephone interviews. A validated (in Sri Lanka) version of the Short Form 36 health survey questionnaire (SF-36) was used to assess multi-item dimensions health status of the patients at 1, 2 and 3 mo postdischarge.
We collected data on 203 patients (male, n=111 [54.7%]). The level of vaccination was significantly associated with disease severity (p<0.001). Early recovery was seen in the mild group compared with the moderate and severe groups. At 3 mo, on average 98% of mild and 90% of moderate/severe patients had recovered. Based on the SF-36, physical functioning dimensions, role limitation due to physical and emotional health, energy/ fatigue, emotional well-being, social functioning, pain and general health were significantly different in the moderate/severe vs mild COVID-19 groups at 1, 2 and 3 mo postdischarge (p<0.05). Twenty-three patients developed complications, of which the most common were myocardial infarction with heart failure (n=6/23; 26.1%), cerebrovascular accident (n=6/23; 26.1%) and respiratory tract infections (n=3/23; 13.01%) and there were six deaths.
In our cohort, receiving two doses of the COVID-19 vaccine was associated with reduced disease severity. Those with mild disease recovered faster than those with moderate/severe disease. At 3 mo posthospital discharge, >90% had recovered.</description><identifier>ISSN: 0035-9203</identifier><identifier>EISSN: 1878-3503</identifier><identifier>DOI: 10.1093/trstmh/trac039</identifier><identifier>PMID: 35483750</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Aftercare ; COVID-19 - epidemiology ; COVID-19 Vaccines ; Humans ; Male ; Original ; Patient Discharge ; Prospective Studies ; SARS-CoV-2 ; Sri Lanka - epidemiology</subject><ispartof>Transactions of the Royal Society of Tropical Medicine and Hygiene, 2022-12, Vol.116 (12), p.1129-1137</ispartof><rights>The Author(s) 2022. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene.</rights><rights>The Author(s) 2022. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-7b5b490a3f80257d0ab471f9f5cf5233f9a43e8ad6bc21dcd4e410c43f0c38ba3</citedby><cites>FETCH-LOGICAL-c390t-7b5b490a3f80257d0ab471f9f5cf5233f9a43e8ad6bc21dcd4e410c43f0c38ba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,778,782,883,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35483750$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abeysuriya, Visula</creatorcontrib><creatorcontrib>Seneviratne, Suranjith L</creatorcontrib><creatorcontrib>De Silva, Arjuna P</creatorcontrib><creatorcontrib>Mowjood, Riaz</creatorcontrib><creatorcontrib>Mowjood, Shazli</creatorcontrib><creatorcontrib>de Silva, Thushara</creatorcontrib><creatorcontrib>de Mel, Primesh</creatorcontrib><creatorcontrib>de Mel, Chandima</creatorcontrib><creatorcontrib>Wijesinha, R S</creatorcontrib><creatorcontrib>Fernando, Amitha</creatorcontrib><creatorcontrib>de Mel, Sanjay</creatorcontrib><creatorcontrib>Chandrasena, Lal</creatorcontrib><title>Postdischarge outcomes of COVID-19 patients from South Asia: a prospective study</title><title>Transactions of the Royal Society of Tropical Medicine and Hygiene</title><addtitle>Trans R Soc Trop Med Hyg</addtitle><description>Coronavirus disease 2019 (COVID-19) may cause clinical manifestations that last for weeks or months after hospital discharge. The manifestations are heterogeneous and vary in their frequency. Their multisystem nature requires a holistic approach to management. There are sparse data from the South Asian region on the outcomes of hospital-discharged COVID-19 patients. We assessed the posthospital discharge outcomes of a cohort of Sri Lankan COVID-19 patients and explored the factors that influenced these outcomes.
Data were prospectively collected from patients who were discharged following an admission to the Nawaloka Hospital, Sri Lanka with COVID-19 from March to June 2021. At discharge, their demographic, clinical and laboratory findings were recorded. The patients were categorised as having mild, moderate and severe COVID-19, based on the Sri Lanka Ministry of Health COVID-19 guidelines. Following discharge, information on health status, complications and outcomes was collected through clinic visits and preplanned telephone interviews. A validated (in Sri Lanka) version of the Short Form 36 health survey questionnaire (SF-36) was used to assess multi-item dimensions health status of the patients at 1, 2 and 3 mo postdischarge.
We collected data on 203 patients (male, n=111 [54.7%]). The level of vaccination was significantly associated with disease severity (p<0.001). Early recovery was seen in the mild group compared with the moderate and severe groups. At 3 mo, on average 98% of mild and 90% of moderate/severe patients had recovered. Based on the SF-36, physical functioning dimensions, role limitation due to physical and emotional health, energy/ fatigue, emotional well-being, social functioning, pain and general health were significantly different in the moderate/severe vs mild COVID-19 groups at 1, 2 and 3 mo postdischarge (p<0.05). Twenty-three patients developed complications, of which the most common were myocardial infarction with heart failure (n=6/23; 26.1%), cerebrovascular accident (n=6/23; 26.1%) and respiratory tract infections (n=3/23; 13.01%) and there were six deaths.
In our cohort, receiving two doses of the COVID-19 vaccine was associated with reduced disease severity. Those with mild disease recovered faster than those with moderate/severe disease. At 3 mo posthospital discharge, >90% had recovered.</description><subject>Aftercare</subject><subject>COVID-19 - epidemiology</subject><subject>COVID-19 Vaccines</subject><subject>Humans</subject><subject>Male</subject><subject>Original</subject><subject>Patient Discharge</subject><subject>Prospective Studies</subject><subject>SARS-CoV-2</subject><subject>Sri Lanka - epidemiology</subject><issn>0035-9203</issn><issn>1878-3503</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUctOwzAQtBAIyuPKEfnIJbDOxk3MAQmVp1SpSDyuluPYNKipg-1U4u8xakFwmsPOzs7OEHLM4IyBwPPoQ-zmCZQGFFtkxKqyypADbpMRAPJM5IB7ZD-Ed4CcMy52yR7yosKSw4g8ProQmzboufJvhrohateZQJ2lk9nrw3XGBO1VbM0yBmq96-hT4szpVWjVBVW09y70Rsd2ZWiIQ_N5SHasWgRztMED8nJ78zy5z6azu4fJ1TTTKCBmZc3rQoBCWyVXZQOqLkpmheXa8hzRClWgqVQzrnXOGt0UpmCgC7SgsaoVHpDLtW4_1J1pdDLo1UL2vu2U_5ROtfL_ZNnO5ZtbScFywYRIAqcbAe8-BhOi7FIMZrFQS-OGIPMxr3IEPmaJeram6vRt8Mb-nmEgv2uQ6xrkpoa0cPLX3C_9J3f8AngNh70</recordid><startdate>20221202</startdate><enddate>20221202</enddate><creator>Abeysuriya, Visula</creator><creator>Seneviratne, Suranjith L</creator><creator>De Silva, Arjuna P</creator><creator>Mowjood, Riaz</creator><creator>Mowjood, Shazli</creator><creator>de Silva, Thushara</creator><creator>de Mel, Primesh</creator><creator>de Mel, Chandima</creator><creator>Wijesinha, R S</creator><creator>Fernando, Amitha</creator><creator>de Mel, Sanjay</creator><creator>Chandrasena, Lal</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20221202</creationdate><title>Postdischarge outcomes of COVID-19 patients from South Asia: a prospective study</title><author>Abeysuriya, Visula ; Seneviratne, Suranjith L ; De Silva, Arjuna P ; Mowjood, Riaz ; Mowjood, Shazli ; de Silva, Thushara ; de Mel, Primesh ; de Mel, Chandima ; Wijesinha, R S ; Fernando, Amitha ; de Mel, Sanjay ; Chandrasena, Lal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-7b5b490a3f80257d0ab471f9f5cf5233f9a43e8ad6bc21dcd4e410c43f0c38ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aftercare</topic><topic>COVID-19 - epidemiology</topic><topic>COVID-19 Vaccines</topic><topic>Humans</topic><topic>Male</topic><topic>Original</topic><topic>Patient Discharge</topic><topic>Prospective Studies</topic><topic>SARS-CoV-2</topic><topic>Sri Lanka - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abeysuriya, Visula</creatorcontrib><creatorcontrib>Seneviratne, Suranjith L</creatorcontrib><creatorcontrib>De Silva, Arjuna P</creatorcontrib><creatorcontrib>Mowjood, Riaz</creatorcontrib><creatorcontrib>Mowjood, Shazli</creatorcontrib><creatorcontrib>de Silva, Thushara</creatorcontrib><creatorcontrib>de Mel, Primesh</creatorcontrib><creatorcontrib>de Mel, Chandima</creatorcontrib><creatorcontrib>Wijesinha, R S</creatorcontrib><creatorcontrib>Fernando, Amitha</creatorcontrib><creatorcontrib>de Mel, Sanjay</creatorcontrib><creatorcontrib>Chandrasena, Lal</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Transactions of the Royal Society of Tropical Medicine and Hygiene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abeysuriya, Visula</au><au>Seneviratne, Suranjith L</au><au>De Silva, Arjuna P</au><au>Mowjood, Riaz</au><au>Mowjood, Shazli</au><au>de Silva, Thushara</au><au>de Mel, Primesh</au><au>de Mel, Chandima</au><au>Wijesinha, R S</au><au>Fernando, Amitha</au><au>de Mel, Sanjay</au><au>Chandrasena, Lal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Postdischarge outcomes of COVID-19 patients from South Asia: a prospective study</atitle><jtitle>Transactions of the Royal Society of Tropical Medicine and Hygiene</jtitle><addtitle>Trans R Soc Trop Med Hyg</addtitle><date>2022-12-02</date><risdate>2022</risdate><volume>116</volume><issue>12</issue><spage>1129</spage><epage>1137</epage><pages>1129-1137</pages><issn>0035-9203</issn><eissn>1878-3503</eissn><abstract>Coronavirus disease 2019 (COVID-19) may cause clinical manifestations that last for weeks or months after hospital discharge. The manifestations are heterogeneous and vary in their frequency. Their multisystem nature requires a holistic approach to management. There are sparse data from the South Asian region on the outcomes of hospital-discharged COVID-19 patients. We assessed the posthospital discharge outcomes of a cohort of Sri Lankan COVID-19 patients and explored the factors that influenced these outcomes.
Data were prospectively collected from patients who were discharged following an admission to the Nawaloka Hospital, Sri Lanka with COVID-19 from March to June 2021. At discharge, their demographic, clinical and laboratory findings were recorded. The patients were categorised as having mild, moderate and severe COVID-19, based on the Sri Lanka Ministry of Health COVID-19 guidelines. Following discharge, information on health status, complications and outcomes was collected through clinic visits and preplanned telephone interviews. A validated (in Sri Lanka) version of the Short Form 36 health survey questionnaire (SF-36) was used to assess multi-item dimensions health status of the patients at 1, 2 and 3 mo postdischarge.
We collected data on 203 patients (male, n=111 [54.7%]). The level of vaccination was significantly associated with disease severity (p<0.001). Early recovery was seen in the mild group compared with the moderate and severe groups. At 3 mo, on average 98% of mild and 90% of moderate/severe patients had recovered. Based on the SF-36, physical functioning dimensions, role limitation due to physical and emotional health, energy/ fatigue, emotional well-being, social functioning, pain and general health were significantly different in the moderate/severe vs mild COVID-19 groups at 1, 2 and 3 mo postdischarge (p<0.05). Twenty-three patients developed complications, of which the most common were myocardial infarction with heart failure (n=6/23; 26.1%), cerebrovascular accident (n=6/23; 26.1%) and respiratory tract infections (n=3/23; 13.01%) and there were six deaths.
In our cohort, receiving two doses of the COVID-19 vaccine was associated with reduced disease severity. Those with mild disease recovered faster than those with moderate/severe disease. At 3 mo posthospital discharge, >90% had recovered.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>35483750</pmid><doi>10.1093/trstmh/trac039</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Transactions of the Royal Society of Tropical Medicine and Hygiene, 2022-12, Vol.116 (12), p.1129-1137 |
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| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Aftercare COVID-19 - epidemiology COVID-19 Vaccines Humans Male Original Patient Discharge Prospective Studies SARS-CoV-2 Sri Lanka - epidemiology |
| title | Postdischarge outcomes of COVID-19 patients from South Asia: a prospective study |
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