Synthesis, Tumor Specificity, and Photosensitizing Efficacy of Erlotinib-Conjugated Chlorins and Bacteriochlorins: Identification of a Highly Effective Candidate for Photodynamic Therapy of Cancer

Erlotinib was covalently linked to 3-(1'-hexyloxy)ethyl-3-devinylpyropheophorbide-a (HPPH) and structurally related chlorins and bacteriochlorins at different positions of the tetrapyrrole ring. The functional consequence of each modification was determined by quantifying the uptake and subcell...

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Veröffentlicht in:	Journal of medicinal chemistry 2021-01, Vol.64 (1), p.741-767
Hauptverfasser:	Cheruku, Ravindra R, Cacaccio, Joseph, Durrani, Farukh A, Tabaczynski, Walter A, Watson, Ramona, Siters, Kevin, Missert, Joseph R, Tracy, Erin C, Dukh, Mykhaylo, Guru, Khurshid, Koya, Richard C, Kalinski, Pawel, Baumann, Heinz, Pandey, Ravindra K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Cell Survival - drug effects Coculture Techniques Erlotinib Hydrochloride - chemistry Female Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - mortality Head and Neck Neoplasms - pathology Humans Mice Mice, SCID Photochemotherapy Photosensitizing Agents - chemical synthesis Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacology Photosensitizing Agents - therapeutic use Porphyrins - chemistry Stereoisomerism Structure-Activity Relationship Survival Rate
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