Anti-adhesion and Anti-inflammatory Potential of the Leaderless Class IIb Bacteriocin Enterocin DD14
In this study, we investigate the interactions between the leaderless class IIb bacteriocin, enterocin DD14 (EntDD14), or the methicillin or the combination of these antibacterials, and two methicillin-resistant Staphylococcus aureus strains (MRSA-S1 and USA 300) which are respectively a clinical st...
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| Veröffentlicht in: | Probiotics and antimicrobial proteins 2022-08, Vol.14 (4), p.613-619 |
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| creator | Teiar, Radja Pérez-Ramos, Adrián Zgheib, Hassan Cudennec, Benoit Belguesmia, Yanath Drider, Djamel |
| description | In this study, we investigate the interactions between the leaderless class IIb bacteriocin, enterocin DD14 (EntDD14), or the methicillin or the combination of these antibacterials, and two methicillin-resistant
Staphylococcus aureus
strains (MRSA-S1 and USA 300) which are respectively a clinical strain and a reference strain. The results obtained showed that EntDD14 alone or in combination with the antibiotic could significantly prevent the adhesion of these pathogenic bacteria to human cells. On the other hand, we investigated the anti-inflammatory effect of EntDD14 on the secretion of pro-inflammatory interleukins, including IL-6 and IL-8. The results show that EntDD14 is able to decrease significantly the secretion of both interleukins on Caco-2 cells following their treatments with lipopolysaccharides. These novel data provide insightful informations to support applications of bacteriocins as therapeutic agents capable as well to defeat pathogenic bacteria and concomitantly limit their inflammatory reactions. |
| doi_str_mv | 10.1007/s12602-022-09954-0 |
| format | Article |
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These novel data provide insightful informations to support applications of bacteriocins as therapeutic agents capable as well to defeat pathogenic bacteria and concomitantly limit their inflammatory reactions.</description><subject>Antibiotics</subject><subject>Applied Microbiology</subject><subject>Bacteria</subject><subject>Bacteriocins</subject><subject>Biotechnology</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Computer Science</subject><subject>Drug resistance</subject><subject>Feces</subject><subject>Gram-positive bacteria</subject><subject>Inflammation</subject><subject>Interleukin 6</subject><subject>Interleukin 8</subject><subject>Lipopolysaccharides</subject><subject>Methicillin</subject><subject>Microbiology</subject><subject>Nutrition</subject><subject>Peptides</subject><subject>Probiotics</subject><subject>Protein Science</subject><subject>Proteins</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus infections</subject><issn>1867-1306</issn><issn>1867-1314</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kUFvFCEUx4mxsbX6BTwYEi96GH3AwDAXk-22tptsogc9EwaYLs0MVJht0m8vu1PX2kMPwMvj9_7vwR-hdwQ-E4DmSyZUAK2AltW2vK7gBTohUjQVYaR-eYhBHKPXOd8ACMEovELHjAuoOeUnyC7C5CttNy77GLAOFu8zPvSDHkc9xXSPf8TJlaQecOzxtHF47bR1aXA54-Wgy75adfhMm8klH40P-CKUcB-dn5P6DTrq9ZDd24fzFP36dvFzeVWtv1-ulot1ZTjIqWp4K0zTSAk96bvW2IZoYqAD0DWhbWedFpZpKnkvtWuZcFYYZglva0okI-wUfZ11b7fd6KwpQyc9qNvkR53uVdRe_X8T_EZdxzvVEspZLYvAp1lg86TsarFWuxzUjEpG6d2u2ceHZin-3ro8qdFn44ZBBxe3WVEhJKVUAi_ohyfoTdymUL6iUJLypiGiLRSdKZNizsn1hwkIqJ3hajZcFcPV3nAFpej94ycfSv46XAA2A7lchWuX_vV-RvYPTrm0_g</recordid><startdate>20220801</startdate><enddate>20220801</enddate><creator>Teiar, Radja</creator><creator>Pérez-Ramos, Adrián</creator><creator>Zgheib, Hassan</creator><creator>Cudennec, Benoit</creator><creator>Belguesmia, Yanath</creator><creator>Drider, Djamel</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>1XC</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6841-6254</orcidid><orcidid>https://orcid.org/0000-0002-3113-1578</orcidid><orcidid>https://orcid.org/0000-0002-5505-4458</orcidid></search><sort><creationdate>20220801</creationdate><title>Anti-adhesion and Anti-inflammatory Potential of the Leaderless Class IIb Bacteriocin Enterocin DD14</title><author>Teiar, Radja ; 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strains (MRSA-S1 and USA 300) which are respectively a clinical strain and a reference strain. The results obtained showed that EntDD14 alone or in combination with the antibiotic could significantly prevent the adhesion of these pathogenic bacteria to human cells. On the other hand, we investigated the anti-inflammatory effect of EntDD14 on the secretion of pro-inflammatory interleukins, including IL-6 and IL-8. The results show that EntDD14 is able to decrease significantly the secretion of both interleukins on Caco-2 cells following their treatments with lipopolysaccharides. These novel data provide insightful informations to support applications of bacteriocins as therapeutic agents capable as well to defeat pathogenic bacteria and concomitantly limit their inflammatory reactions.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>35604525</pmid><doi>10.1007/s12602-022-09954-0</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-6841-6254</orcidid><orcidid>https://orcid.org/0000-0002-3113-1578</orcidid><orcidid>https://orcid.org/0000-0002-5505-4458</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Probiotics and antimicrobial proteins, 2022-08, Vol.14 (4), p.613-619 |
| issn | 1867-1306 1867-1314 |
| language | eng |
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| source | SpringerLink Journals |
| subjects | Antibiotics Applied Microbiology Bacteria Bacteriocins Biotechnology Chemistry Chemistry and Materials Science Chemistry/Food Science Computer Science Drug resistance Feces Gram-positive bacteria Inflammation Interleukin 6 Interleukin 8 Lipopolysaccharides Methicillin Microbiology Nutrition Peptides Probiotics Protein Science Proteins Staphylococcus aureus Staphylococcus infections |
| title | Anti-adhesion and Anti-inflammatory Potential of the Leaderless Class IIb Bacteriocin Enterocin DD14 |
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