Oxysterol Compounds in Mouse Mutant αA- and αB-Crystallin Lenses Can Improve the Optical Properties of the Lens

To investigate how cataract-linked mutations affect the gradient refractive index (GRIN) and lens opacification in mouse lenses and whether there is any effect on the optics of the lens from treatment with an oxysterol compound. A total of 35 mice including wild-type and knock-in mutants (Cryaa-R49C...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2022-05, Vol.63 (5), p.15
Hauptverfasser:	Wang, Kehao, Hoshino, Masato, Uesugi, Kentaro, Yagi, Naoto, Pierscionek, Barbara K, Andley, Usha P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cataract - genetics Crystallins - genetics Disease Models, Animal Lens Lens, Crystalline - metabolism Lens, Crystalline - physiology Mice Oxysterols - pharmacology
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