Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control

Mycobacterium tuberculosis lung infection results in a complex multicellular structure: the granuloma. In some granulomas, immune activity promotes bacterial clearance, but in others, bacteria persist and grow. We identified correlates of bacterial control in cynomolgus macaque lung granulomas by co...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2022-05, Vol.55 (5), p.827-846.e10
Hauptverfasser:	Gideon, Hannah P., Hughes, Travis K., Tzouanas, Constantine N., Wadsworth, Marc H., Tu, Ang Andy, Gierahn, Todd M., Peters, Joshua M., Hopkins, Forrest F., Wei, Jun-Rong, Kummerlowe, Conner, Grant, Nicole L., Nargan, Kievershen, Phuah, Jia Yao, Borish, H. Jacob, Maiello, Pauline, White, Alexander G., Winchell, Caylin G., Nyquist, Sarah K., Ganchua, Sharie Keanne C., Myers, Amy, Patel, Kush V., Ameel, Cassaundra L., Cochran, Catherine T., Ibrahim, Samira, Tomko, Jaime A., Frye, Lonnie James, Rosenberg, Jacob M., Shih, Angela, Chao, Michael, Klein, Edwin, Scanga, Charles A., Ordovas-Montanes, Jose, Berger, Bonnie, Mattila, Joshua T., Madansein, Rajhmun, Love, J. Christopher, Lin, Philana Ling, Leslie, Alasdair, Behar, Samuel M., Bryson, Bryan, Flynn, JoAnne L., Fortune, Sarah M., Shalek, Alex K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ecosystem Granuloma immunology intercellular interactions Lung Macaca fascicularis Mycobacterium tuberculosis PET-CT Pulmonary Fibrosis - pathology scRNA-seq single-cell RNA sequencing Tuberculosis type 1-type 17 type 2 responses
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!