Kaposi’s sarcoma herpesvirus activates the hypoxia response to usurp HIF2α-dependent translation initiation for replication and oncogenesis

Kaposi’s sarcoma herpesvirus (KSHV) is an angiogenesis-inducing oncovirus whose ability to usurp the oxygen-sensing machinery is central to its oncogenicity. By upregulating the hypoxia-inducible factors (HIFs), KSHV reprograms infected cells to a hypoxia-like state, triggering angiogenesis. Here we...

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Veröffentlicht in:	Cell reports (Cambridge) 2021-12, Vol.37 (13), p.110144-110144, Article 110144
Hauptverfasser:	Méndez-Solís, Omayra, Bendjennat, Mourad, Naipauer, Julian, Theodoridis, Phaedra R., Ho, J.J. David, Verdun, Ramiro E., Hare, Joshua M., Cesarman, Ethel, Lee, Stephen, Mesri, Enrique A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Carcinogenesis - genetics Carcinogenesis - metabolism Carcinogenesis - pathology eIF4E2 cap binding EPAS1 Eukaryotic Initiation Factor-4E - genetics Eukaryotic Initiation Factor-4E - metabolism Herpesvirus 8, Human - physiology HHV-8 Humans Hypoxia - physiopathology hypoxia-inducible factors Kaposi’s sarcoma herpesvirus KSHV oxygen-regulated translation initiation PDGFRA Peptide Chain Initiation, Translational Sarcoma, Kaposi - genetics Sarcoma, Kaposi - metabolism Sarcoma, Kaposi - pathology Sarcoma, Kaposi - virology viral oncogenesis viral replication Virus Activation Virus Replication
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